Influence of Muscle Strength on the Energy Cost of Walking in Obese Subjects

NCT01794377 | Completed

• 2 other identifiers: OBELIX2012/CHU/01
• Study Type: interventional
• Target: 59
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to evaluate the efficacy of 2 physical exercise training programs, with a supplementation in fruits and vegetables, on energy cost of walking. 60 subjects will be randomized into 2 groups. The first program will be consist of an interval strength training for 30 min on bicycle ergometer (which include strengthening exercises in an high intensity interval training). The second program will be conducted at a relatively low intensity of effort, corresponding to 50% of oxygen uptake (VO2) peak measured by indirect calorimetry. All subjects will receive a free supplement of 5 fruits and vegetables per day during all the intervention. The intervention will last 9 months in total : 5 month at the hospital fallow by 4 month at home.

Conditions

Obesity

Keywords

Obesity

Outcome Measures

Primary Outcomes (1)

• Energy cost of walking, expressed in Joules per kilogram per meter (J/kg/m).

  Measure of the energy cost reduction between M0, M5 and M9

  At the inclusion (M0), and at M5 and at the end of the study at M9

Secondary Outcomes (8)

• Muscle strength

  At the inclusion (M0), and at M5 and at the end of the study at M9

• Biomechanism of walking

  At the inclusion (M0), and at M5 and at the end of the study at M9

• Walking intensity

  At the inclusion (M0), and at M5 and at the end of the study at M9

• Body composition

  At the inclusion (M0), and at M5 and at the end of the study at M9

• Change in biological parameters

  At the inclusion (M0), and at M5 and at the end of the study at M9

Study Arms (2)

40 of an endurance training

ACTIVE COMPARATOR

Endurance training at 50% of VO2 peak measured by indirect calorimetry. Dietary Supplement: supplementation in fruits and vegetables.

Behavioral: 40 of an endurance training

30 minutes of a high intensity training

EXPERIMENTAL

This arm consist of an interval strength training for 30 min on bicycle ergometer (which include strengthening exercises in an high intensity interval training). Dietary Supplement: supplementation in fruits and vegetables.

Behavioral: 30 minutes of high intensity training

Interventions

30 minutes of high intensity training BEHAVIORAL

This group will carry out a 5-min warm-up period on bicycle ergometer at an intensity corresponding to 50% of Vo2max before performed eight times the intermittent training exercise as follows: * 30 sec at 120% of Vo2max, * 1 min at 50% of Vo2max, * 15 sec at 30-40 revolutions per minute of strength training at 100% of the maximal anaerobic power, which will be first determined by means of a force-velocity test on a Monark ergometer, * 1 min at 50% of Vo2max. The training session will be terminated by a 3-min cool-down period at 40% of Vo2max. Training three times per week for 5 months under supervision of an exercise physiologist. Initial nutritional education session at the beginning of the study Questionnaires on training experience during the 5 months training period (Exercise difficulties, pain...). Dietary Supplement: supplementation in fruits and vegetables (5 per day) during all the study.

30 minutes of a high intensity training

40 of an endurance training BEHAVIORAL

The moderate-intensity continuous exercise group will carry out a 40-min session of continuous cycling at a moderate intensity (50 % of Vo2max). Training three times per week for 5 months under supervision of an exercise physiologist. Initial nutritional education session at the beginning of the study Questionnaires on training experience during the 5 months training period (Exercise difficulties, pain...). Dietary Supplement: supplementation in fruits and vegetables (5 per day) during all the study.

40 of an endurance training

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Men and women
• years old
• ≤ BMI ≤40 kg / m²
• sedentary
• considered clinically stable
• able to rehabilitation training
• having signed an informed consent
• without professional activity

You may not qualify if:

• blood glucose ≥ 1.26 g / l
• HbA1c ≥ 6.5%
• severe hypertension (Systolic Blood Pressure (SBP) ≥ 180 mmHg and / or Diastolic Blood Pressure (DBP) ≥ 110 mmHg)
• hypertension (≥140/90 mmHg) untreated or treated by beta blocker or calcium blocker
• absolute and relative contraindication to the maximal exercise test (ACC / American Heart Association 2002) and / or physical training
• inability to achieve the maximum exercise test and / or the metabolic exercise test by indirect calorimeter
• uncompensated cardiovascular and / or respiratory disease revealed by exercise test
• pacemaker or defibrillator
• recent cardiovascular events (heart failure, treated by positive inotropic drugs, angioplasty within the last 10 days, cardiac surgery within the last 3 months, valvular disease requiring surgical correction, evolving myopericarditis, severe ventricular arrhythmias non stabilized under treatment)
• known and documented myopathy
• cancer
• acute and chronic inflammatory disease
• end stage renal disease
• digestive system operation
• treated by corticoids, thyroid hormone, antidepressant or neuroleptics

Sponsors & Collaborators

• Centre Hospitalier Universitaire de la Réunion: lead
• Universite de La Reunion: collaborator

Study Sites (1)

CHU de La Réunion

Saint-Pierre, La Réunion, 97448, France

Location

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Stephane Schneebeli, PI

  CHU de La Réunion

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 15, 2013
• First Posted: February 18, 2013
• Study Start: February 1, 2013
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2013
• Last Updated: July 25, 2014

Record last verified: 2014-07

Locations

FR (1)