Physical Activity and Food Intake Interaction: Effect of Weight Loss in Obese Adolescent

NCT02664844 | Completed

• 1 other identifier: CHU-0255
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

In obese adolescents, energy expenditure (EE) of chronic high intensity muscular exercise (\> 70% VO2max) conducted one hour before a meal causes an anorectic effect at lunch and dinner the same day. The effect on food intake of the distribution of this exercise into two sessions during 24h remains to be determined. In addition, a multidisciplinary load of obesity generates a loss of body weight in the short term, which we do not know the effects on energy balance. To our knowledge, the impact of weight loss on the anorectic effect of muscle exercise is unknown.

Conditions

Obesity

Keywords

Obesity; Appetite regulation; Insulin sensitivity; Adolescents; Exercise

Outcome Measures

Primary Outcomes (1)

• Comparison between(M0) and (M4) of food intake on 24 hours (total and per meal)

  Comparison between(M0) and (M4) of food intake on 24 hours (total and per meal) assessed during a day with the completion of intense exercise performed in one session EX1, in two sessions (EX2) or sedentary (without exercise: SED). The exercise-induced energy expenditure by 40 minutes at 70% of VO2 max is the same in EX1 and EX2.

  after 4 months of physical activity

Secondary Outcomes (4)

• Comparison between(M0) and (M4) of the Flint scale

  after 4 months of physical activity

• Comparison between(M0) and (M4) of the Pittsburg scale

  after 4 months of physical activity

• Comparison between(M0) and (M4) of HOMA-IR

  after 4 months of physical activity

• Comparison between(M0) and (M4) of Fitness

  after 4 months of physical activity

Study Arms (1)

Obese adolescent

EXPERIMENTAL

Behavioral: Physical activity

Interventions

Physical activity BEHAVIORAL

Obese adolescent

Eligibility Criteria

• Age: 12 Years - 18 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Overweight adolescents (over the 90 th percentile of the international cut-off point)
• Sedentary (according to the IPAQ-A questionnaire)
• Without eating disorders (according to the DEBQ questionnaire)

You may not qualify if:

• Medical or surgical antecedents that are incompatible with the study: cardiovascular, endocrine or digestive disease.
• Drugs that could interfere with the results of the study
• Surgical intervention in the 3 months
• Regular consumption of tobacco or Alcohol
• patients on a diet with caloric restriction
• Refusal to sign the consent form
• Regular practice of sport and intensive

Sponsors & Collaborators

• University Hospital, Clermont-Ferrand: lead

Study Sites (1)

CHU Clermont-Ferrand

Clermont-Ferrand, 63003, France

Location

MeSH Terms

Conditions

Obesity; Insulin Resistance; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 15, 2016
• First Posted: January 27, 2016
• Study Start: September 1, 2013
• Primary Completion: September 1, 2015
• Study Completion: December 1, 2015
• Last Updated: January 27, 2016

Record last verified: 2016-01

Locations

FR (1)