Cognitive Phenotypes in Parkinson's Disease

NCT01792843 | Completed DMC

• 2 other identifiers: 2012_262012-A01317-36.
• Study Type: observational
• Target: 158
• Locations: 1 country
• Sites: 1

Brief Summary

• a data driven approach has identified different cognitive phenotypes in Parkinson's disease (PD)
• this heterogeneity possibly reflects the diversity of the neuronal damage caused by the disease
• we hypothesize that the different clinical presentations are associated to specific anatomical and functional correlates

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (1)

• Frequency (%) of the cognitive profile

  Frequency of the different observed cognitive profile, as coming from the cluster analysis

  2 years

Secondary Outcomes (1)

• Grey matter density (voxels)

  2 years

Other Outcomes (1)

• EEG power (microvolts2)

  2 years

Study Arms (1)

Parkinson's disease

Patients with Parkinson's disease according to international criteria

Behavioral: data

Interventions

data BEHAVIORAL

* comparisons of clinical characteristics * comparisons of cognitive profiles * comparisons of grey matter density patterns * comparisons of EEG rhythms features

Parkinson's disease

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with Parkinson's disease, according to international criteria, irrespective of their disease stage or their current antiparkinsonian medication

You may qualify if:

• Males or females;
• to 80 years;
• Parkinson's disease, according to international criteria;
• Without neurological co-morbidity;
• Benefiting from health insurance;
• Having read and understood the information form and having signed the consent form.

You may not qualify if:

• Pregnant or breastfeeding women;
• Parkinsonian syndrome other than PD;
• Currently participating in an other clinical trial or study;
• Patient whose physical or mental condition is incompatible with the study assessments;
• Person under tutorship or curatorship;
• Subjects with claustrophobia
• Subjects carrying incompatible metallic devices such as pacemakers and certain mechanical valves
• PD patients treated by deep brain stimulation

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

Maastricht University Medical Centre

Maastricht, Netherlands

Location

Related Publications (1)

• Carey G, Lopes R, Viard R, Betrouni N, Kuchcinski G, Devignes Q, Defebvre L, Leentjens AFG, Dujardin K. Anxiety in Parkinson's disease is associated with changes in the brain fear circuit. Parkinsonism Relat Disord. 2020 Nov;80:89-97. doi: 10.1016/j.parkreldis.2020.09.020. Epub 2020 Sep 19.

  PMID: 32979785 DERIVED

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Study Officials

• Kathy Dujardin, PhD

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 13, 2013
• First Posted: February 15, 2013
• Study Start: January 1, 2013
• Primary Completion: September 1, 2014
• Study Completion: December 1, 2014
• Last Updated: February 2, 2017

Record last verified: 2017-02

Data Sharing

• IPD Sharing: Will not share

Locations

NL (1)