NCT02447146

Brief Summary

This is a controlled trial to assess the effects of resistance training on bradykinesia and physical function in patients with Parkinson's Disease. Forty patients diagnosed with Parkinson Disease stage 1 to 3 of the Hoehn and Yahr scale took part in the study and were allocated into 2 groups; Training Group performed a 9-week RT program twice a week while the Control Group attended lectures on the disease.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
40

participants targeted

Target at P50-P75 for not_applicable parkinson-disease

Timeline
Completed

Started Jan 2013

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2013

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2014

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2014

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

May 12, 2015

Completed
6 days until next milestone

First Posted

Study publicly available on registry

May 18, 2015

Completed
Last Updated

May 18, 2015

Status Verified

May 1, 2015

Enrollment Period

1.4 years

First QC Date

May 12, 2015

Last Update Submit

May 13, 2015

Conditions

Parkinson Disease

Outcome Measures

Primary Outcomes (2)

  • Bradykinesia measured with Unified Parkinson's Disease Rating Scale, section III

    One time point; after the end of 9-week resistance training

  • Functional Performance measured with Ten Meters Walk Test.

    One time point; after the end of 9-week resistance training

Secondary Outcomes (1)

  • Muscle strength measured with isokinetic peak torque.

    One time point; after the end of 9-week resistance training

Study Arms (2)

Training group

EXPERIMENTAL

9-week resistance training program

Other: Resistance Training

Control group

OTHER

'Lectures on the disease'

Other: Lectures on the disease

Interventions

Resistance TrainingOTHER

The TG performed the RT program using weight machines. Before the training period, participants underwent three weeks with eight familiarization sessions to ensure proper technique execution. The protocol aimed to workout major muscle groups and involved the following exercises: chest press, knee extension, hamstrings curl, leg press, and seated row. Training sessions lasted approximately 50-60 minutes with 2 sets of 10-12 repetitions until fatigue.

Training group
Lectures on the diseaseOTHER

The control group attended an orientation program with lectures on health, quality of life and scientific update on disease.

Control group

Eligibility Criteria

Age50 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Medical neurologist confirmation of 1-3 Hoehn and Yahr stages,
  • age between 50 and 80 years old;
  • and physician attested to participate in the resistance training program.

You may not qualify if:

  • Diagnostic of any other neurological disease, cardiovascular disease, hematologic or orthopedic disorders;
  • and motor fluctuations or severe dyskinesia that could affect their ability to perform the experimental protocol.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (4)

  • Dibble LE, Hale TF, Marcus RL, Droge J, Gerber JP, LaStayo PC. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease. Mov Disord. 2006 Sep;21(9):1444-52. doi: 10.1002/mds.20997.

    PMID: 16773643BACKGROUND

  • Falvo MJ, Sirevaag EJ, Rohrbaugh JW, Earhart GM. Resistance training induces supraspinal adaptations: evidence from movement-related cortical potentials. Eur J Appl Physiol. 2010 Jul;109(5):923-33. doi: 10.1007/s00421-010-1432-8. Epub 2010 Mar 21.

    PMID: 20306270BACKGROUND

  • Fisher BE, Wu AD, Salem GJ, Song J, Lin CH, Yip J, Cen S, Gordon J, Jakowec M, Petzinger G. The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson's disease. Arch Phys Med Rehabil. 2008 Jul;89(7):1221-9. doi: 10.1016/j.apmr.2008.01.013. Epub 2008 Jun 13.

    PMID: 18534554BACKGROUND

  • Allen NE, Canning CG, Sherrington C, Fung VS. Bradykinesia, muscle weakness and reduced muscle power in Parkinson's disease. Mov Disord. 2009 Jul 15;24(9):1344-51. doi: 10.1002/mds.22609.

    PMID: 19425085RESULT

MeSH Terms

Conditions

Parkinson Disease

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Parkinsonian DisordersBasal Ganglia DiseasesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesMovement DisordersSynucleinopathiesNeurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Ricardo Oliveira, PhD

    College of Physical Education - University of Brasilia

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

May 12, 2015

First Posted

May 18, 2015

Study Start

January 1, 2013

Primary Completion

June 1, 2014

Study Completion

December 1, 2014

Last Updated

May 18, 2015

Record last verified: 2015-05