Effect of a Single Dose of Cranberry Beverage on Inflammation and Oxidative Stress
Acute Bioavailability of Cranberry Polyphenols After A Single Dose In Healthy Adults and Its Antioxidative and Anti-Inflammatory Action
1 other identifier
interventional
12
1 country
1
Brief Summary
The purpose of this study is to determine the effects of a single dose of cranberry beverage in healthy adults on the kinetic uptake of polyphenol compounds and polyphenol metabolites, and antioxidative and anti-inflammatory activity.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jul 2010
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2010
CompletedFirst Submitted
Initial submission to the registry
January 29, 2013
CompletedFirst Posted
Study publicly available on registry
January 31, 2013
CompletedResults Posted
Study results publicly available
July 8, 2014
CompletedJuly 8, 2014
June 1, 2014
3 months
January 29, 2013
April 22, 2014
June 4, 2014
Conditions
Keywords
Outcome Measures
Primary Outcomes (16)
Reduced Glutathione (GSH) Concentrations in Red Blood Cells
0, 2, 4, 8, 24 h
Superoxide Dismutase (SOD) Activity in Red Blood Cells
0, 2, 4, 8, 24 h
Glutathione Peroxidase (GPx) Activity in Red Blood Cells
0, 2, 4, 8, 24 h
Oxidative Damage to DNA Assessed by Plasma 8-hydroxy-2'-Deoxyguanosine (8-OHdG)
0, 2, 4, 8, 24 h
C-Reactive Protein (CRP) Concentrations in Plamsa
0, 2, 4, 8, 24 h
Nitric Oxide (NO) Concentrations in Plamsa
0, 2, 4, 8, 24 h
Interleukin-1alpha (IL-1a) Concentrations in Plasma
0, 2, 4, 8, 24 h
Interleukin-1beta (IL-1b) Concentrations in Plasma
0, 2, 4, 8, 24 h
Interleukin-2 (IL-2) Concentrations in Plasma
0, 2, 4, 8, 24 h
Interleukin-4 (IL-4) Concentrations in Plasma
0, 2, 4, 8, 24 h
Interleukin-6 (IL-6) Concentrations in Plasma
0, 2, 4, 8, 24 h
Interleukin-8 (IL-8) Concentrations in Plasma
0, 2, 4, 8, 24 h
Interleukin-10 (IL-10) Concentrations in Plasma
0, 2, 4, 8, 24 h
Interferon-gamma (IFN-y) Concentrations in Plasma
0, 2, 4, 8, 24 h
Tumor Necrosis Factor-alpha (TNF-a) Concentrations in Plasma
0, 2, 4, 8, 24 h
Urinary Anti-bacteria Adhesion Activity
0, 3, 6, 9, 12, 24 h
Study Arms (3)
Low Calorie Cranberry Juice Cocktail
ACTIVE COMPARATORBeverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Cranberry Extract Beverage
ACTIVE COMPARATORBeverage containing cranberry: one dose of 15.2 ounces consumed within 15 minutes
Non-Cranberry Beverage
PLACEBO COMPARATORBeverage absent cranberry: one dose of 15.2 ounces consumed within 15 minutes
Interventions
Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
Beverage containing cranberry at a dose of 15.2 ounces consumed within 15 minutes
Beverage absent cranberry at a dose of 15.2 ounces consumed within 15 minutes
Eligibility Criteria
You may qualify if:
- Men \& women; aged 18-35 years
- BMI: 19-25 kg/m2
You may not qualify if:
- Any significant chronic disease, hypertension, ulcers, dyspepsia, lactose intolerance, allergy, psychotic illness
- Had major gastrointestinal surgery or on prescription or surgical treatment
- Any condition that may interfere with the digestion, absorption, metabolism or excretion of nutrients
- Regularly smoked in the previous 6 months
- On medication or ingested a prescribed drug at any time within the 14 days preceding study enrolment (excluding hormonal contraceptives and hormone replacement therapy) or over-the-counter preparation within 7 days preceding enrolment
- Risk factors for AIDS or known HIV positive status
- Pregnant or lactating
- High intake of chocolate or similar high polyphenol foods
- Regular intake of vitamin and polyphenol supplements
- Drug and alcohol misuse
- Currently participating or had participated in another clinical study during the previous 3 weeks
- Donated blood in the previous 3 weeks
- Exercise more than 3 times/week for longer than 45 min each time
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Washington State Universitylead
- Ocean Spray Cranberries, Inc.collaborator
Study Sites (1)
WSU Bioactives Research Lab
Pullman, Washington, 99164, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Boon P. Chew
- Organization
- Washington State Unviversity
Study Officials
- PRINCIPAL INVESTIGATOR
Boon P Chew, PhD
Washington State University
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, INVESTIGATOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
January 29, 2013
First Posted
January 31, 2013
Study Start
July 1, 2010
Primary Completion
October 1, 2010
Study Completion
December 1, 2010
Last Updated
July 8, 2014
Results First Posted
July 8, 2014
Record last verified: 2014-06