NCT01778309|CompletedDMC
NAC Supplementation and Skeletal Muscle Performance
Effects of NAC Supplementation on Skeletal Muscle Performance Following Aseptic Injury Induced by Exercise
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Effects of NAC Supplementation on Skeletal Muscle Performance Following Aseptic Injury Induced by Exercise
Sponsor study identifier
Secondary identifiers
OTHER · Tzelalis Sports Medicine co.
interventional
20
1 country
1
Study Start
January 2010
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
September 2011
Actual (reported)Study Completion
April 2012
Actual (reported)In this investigation the investigators utilized NAC administration to foster GSH availability during an 8-day period following eccentric exercise-induced muscle damage in order to test our hypotheses: i) antioxidant supplementation does not disturb performance and adaptations induced by exercise-induced muscle injury and ii) redox status perturbations in skeletal muscle are pivotal for the regulation of muscle' inflammatory response and repair.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 2012
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 2010
Date type not reportedThis date has not been verified as actual or estimated.
September 2011
Actual (reported)April 2012
Actual (reported)January 21, 2013
Actual (reported)January 29, 2013
Actual (reported)Change in reduced glutathione in blood
Concentration of reduced glutathione in red blood cells
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in reduced glutathione in muscle
concentration of reduced glutathione in quadriceps skeletal muscle group
one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in protein carbonyls in red blood cells and serum
concentration of protein carbonyls
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
n-acetylcysteine supplementation, orally in three daily dosages, at 20 mg/kg/day, daily for eight days after exercise placebo, orally in three daily dosages, content: 500 mL drink that contained water (375 mL), sugar-free cordial (125 ml), and 2 g of low-calorie glucose/dextrose powder.
n-acetylcysteine administration: 20 mg//kg/day, orally, daily for eight days following exercise placebo administration: 500 mL orally, daily for eight days following exercise
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Laboratory of Physical Education & Sport Performance
Komotini, Thrace, 69100, Greece
Michailidis Y, Karagounis LG, Terzis G, Jamurtas AZ, Spengos K, Tsoukas D, Chatzinikolaou A, Mandalidis D, Stefanetti RJ, Papassotiriou I, Athanasopoulos S, Hawley JA, Russell AP, Fatouros IG. Thiol-based antioxidant supplementation alters human skeletal muscle signaling and attenuates its inflammatory response and recovery after intense eccentric exercise. Am J Clin Nutr. 2013 Jul;98(1):233-45. doi: 10.3945/ajcn.112.049163. Epub 2013 May 29.
Ioannis F Fatouros, Ph.D.
Democritus University of Thrace, Greece
20 participants (actual enrollment reported by the registry).
First Submitted
January 21, 2013
First Posted
January 29, 2013
Study Start
January 2010
Date type not reportedThis date has not been verified as actual or estimated.
Recovery Kinetics Following Change of Direction Training
Change in protein carbonyls in muscle
protein carbonyl concentration in vastus lateralis skeletal muscle
one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in thiobarbituric acid reactive substances in red blood cells and serum
thiobarbituric acid reactive substances concentration in serum and red blood cells
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in thiobarbituric acid reactive substances in muscle
thiobarbituric acid reactive substances concentration in vastus lateralis skeletal muscle
one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in oxidized glutathione in red blood cells and blood
Concentration of oxidized glutathione in red blood cells and whole blood
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in total antioxidant capacity in serum
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in oxidized glutathione in muscle
concentration of oxidized glutathione in vastus lateralis skeletal muscle
one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in catalase activity in red blood cells and serum
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in glutathione peroxidase activity in red blood cells
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in creatine kinase activity in plasma
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in C-reactive protein in plasma
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in macrophage infiltration in muscle
one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in white blood cell count in blood
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in neutrophil count in blood
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in fatty acid binding protein in plasma
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in cortisol concentration in blood
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in testosterone concentration in plasma
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in cytokine concentration in plasma
Measurement of IL-1β, IL-4, IL-6, TNF-α, IL-8, IL-10, IL-12p70 concentrations in plasma
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in adhesion molecule concentration in blood
Measurement of ICAM-1, VCAM-1, sP-selectin, sE-selectin concentrations in plasma
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in intracellular signalling proteins in muscle
Measurement of phosphorylation levels of protein kinase B (Akt), mammalian target of rapamycin (mTOR), serine/threonine kinase (p70S6K), ribosomal protein S6 (rpS6), nuclear factor κB (NFκB), serine⁄threonine mitogen activated protein kinase (p38-MAPK) in vastus lateralis muscle.
one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in myogenic determination factor (MyoD) protein levels in muscle
MyoD expression in vastus lateralis muscle
one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in tumor necrosis factor α in muscle
Protein levels of TNF-α in vastus lateralis muscle
one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in muscle function of knee extensor and flexor muscle
one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Body composition
One day before exercise
Maximal aerobic capacity
One day before exercise
Change in profile of dietary intake
one hour before exercise, daily for 8 days post-exercise
Change in side effect occurence
one hour before exercise, daily for 8 days post-exercise
Contact the study team to confirm eligibility.
Primary Completion
September 2011
Actual (reported)Study Completion
April 2012
Actual (reported)Last Updated
January 29, 2013
Record last verified: 2013-01
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