High Intensity Interval Versus Continuous Moderate Intensity Training: Maximizing the Benefits of Exercise in Overweight Adolescents

NCT01935323 | Completed DMC

• 1 other identifier: F121101004
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

6-week, single site, two parallel arm, randomized, controlled trial comparing the effectiveness of a High Intensity Interval Training (HIIT) versus a continuous Moderate Intensity Training (MIT) program on cardiovascular and metabolic health outcomes in overweight adolescent males. HIIT training may be a potent time-efficient strategy to induce similar metabolic and cardiovascular adaptations typically associated with MIT.

Conditions

Metabolism; Physical Fitness

Keywords

high intensity interval training; aerobic exercise; insulin sensitivity; obesity; cardiovascular fitness

Outcome Measures

Primary Outcomes (1)

• Body Composition as measured by DXA

  Baseline and 6 weeks

Secondary Outcomes (25)

• Body Weight

  Baseline and 6 weeks

• Blood Pressure

  Baseline and 6 weeks

• Body Mass Index

  Baseline and 6 weeks

• Peak uptake of volume of oxygen

  Baseline and 6 weeks

• Wingate Cycle test

  Baseline and 6 weeks

Study Arms (2)

High Intensity Interval Training

EXPERIMENTAL

Participants will perform the HIIT protocol on an electronically-braked cycle ergometer (Quinton Excalibur, Quinton Instrument Company, Bothell, WA). Participants will perform a 20-minute protocol, consisting of four minutes of cycling at 15% of maximum anaerobic power (Max-AP) followed by 30 seconds at 85% of Max-AP. These workloads will be based upon pre-trial Wingate tests. This cycle was repeated four times within each protocol, ending with two minutes at 15% of Max-AP. This will be performed 3d/wk for 6wks, with at least 24 hrs between each session.

Other: High Intensity Interval Training

Moderate Intensity Training

ACTIVE COMPARATOR

Participants will perform 45-60 min (graduated over time to 60) of continuous cycling at 65% of VO¬2peak on a Monark cycle ergometer. Workload will be based upon pre-trial VO¬2peak testing. MIT exercise will be performed 5d/wk for 6wks.

Other: Moderate Intensity Training

Interventions

High Intensity Interval Training OTHER

High Intensity Interval Training

Moderate Intensity Training OTHER

Moderate Intensity Training

Eligibility Criteria

• Age: 17 Years - 22 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Ages 17-22
• Men
• BMI (25.0 - 35.0 kg/m2)
• Interested in improving health and fitness

You may not qualify if:

• Weight loss or gain of \>10% of body weight in the past 6 months for any reason.
• Currently taking medication that suppresses or stimulates appetite.
• History of prior surgical procedure for weight control or liposuction.
• Current smoker.
• Any major disease, including:
• Active cancer or cancer requiring treatment in the past 2 years (except nonmelanoma skin cancer).
• Active or chronic infections, including self-reported HIV positivity and active tuberculosis.
• Diagnosed heart conditions.
• Uncontrolled hypertension: systolic blood pressure 160 mm Hg or diastolic blood pressure 95 mm Hg on treatment.
• Gastrointestinal disease, including self-reported chronic hepatitis or cirrhosis, any episode of alcoholic hepatitis or alcoholic pancreatitis within past year, inflammatory bowel disease requiring treatment in the past year, recent or significant abdominal surgery (e.g., gastrectomy).
• Asthma.
• Diagnosed diabetes (type 1 or 2), fasting impaired glucose tolerance (blood glucose 118 mg/dL), or use of any anti-diabetic medications.
• Conditions or behaviors likely to effect the conduct of the trial: unable or unwilling to give informed consent; unable to communicate with the pertinent clinic staff; unwilling to accept treatment assignment by randomization; current or anticipated participation in another intervention research project that would interfere with the intervention offered in the trial; likely to move away from participating clinics before trial completed; unable to walk 0.25 mile in 10 minutes.
• Currently taking antidepressant, steroid, or thyroid medication, unless dosage is stable (no change for 6 months).
• Any active use of illegal or illicit drugs.

Sponsors & Collaborators

• University of Alabama at Birmingham: lead
• The Coca-Cola Company: collaborator

Study Sites (1)

UAB Physiology Lab

Birmingham, Alabama, 35294, United States

Location

Related Publications (1)

• Fisher G, Brown AW, Bohan Brown MM, Alcorn A, Noles C, Winwood L, Resuehr H, George B, Jeansonne MM, Allison DB. High Intensity Interval- vs Moderate Intensity- Training for Improving Cardiometabolic Health in Overweight or Obese Males: A Randomized Controlled Trial. PLoS One. 2015 Oct 21;10(10):e0138853. doi: 10.1371/journal.pone.0138853. eCollection 2015.

  PMID: 26489022 BACKGROUND

Related Links

• UAB Nutrition Obesity Research Center

MeSH Terms

Conditions

Insulin Resistance; Obesity

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 20, 2013
• First Posted: September 5, 2013
• Study Start: February 1, 2013
• Primary Completion: October 1, 2014
• Study Completion: December 1, 2014
• Last Updated: January 12, 2016

Record last verified: 2016-01

Locations

US (1)