Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos

NCT01719068 | Unknown

• 1 other identifier: H12-01812
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This is a pilot study that aims to develop a lung cancer screening program for workers in British Columbia, Canada exposed to asbestos who are at risk of developing lung cancer/pleural mesothelioma. This is high risk population is at of respiratory system diseases as a result of their occupational exposures. Additionally, knowledge garnered from this study will allow us to develop other studies that will further our understanding of asbestos related lung cancer and mesothelioma.

Conditions

Mesothelioma; Lung Cancer

Keywords

Mesothelioma; Lung Cancer; Early Detection

Outcome Measures

Primary Outcomes (1)

• Development of Model to Predict Workers at highest risk of lung cancer/mesothelioma

  3 years

Study Arms (1)

Workers exposed to asbestos

Eligibility Criteria

• Age: 50 Years - 79 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Workers in British Columbia who have been exposed to asbestos.

You may qualify if:

• Women or men age 50 to 79 years
• history of exposure to asbestos at work and one or more of the following:
• lung cancer risk ≥2% over 3 years or
• asbestosis or pleural plaques on a chest x-ray or
• abnormal auto-antibodies level using the EarlyCDT test
• Capable of providing informed consent for screening procedures (low dose spiral CT, lung function, blood biomarkers).

You may not qualify if:

• Any medical condition, such as severe heart disease (e.g. unstable angina, chronic congestive heart failure), acute or chronic respiratory failure, or any disorder, that in the opinion of the physician unlikely to benefit from screening due to shortened life-expectancy from co-existing illnesses
• Have been previously diagnosed with mesothelioma
• Have had other cancer within the past 5 years with the exception of the following cancers: non-melanomatous skin cancer,localized prostate cancer, carcinoma in situ (CIS) of the cervix, or superficial bladder cancer. Treatment of the exceptions must have ended \>6 months before registration into this study
• Pregnancy
• Unwilling to have a low dose CT scan of chest
• Unwilling to sign a consent

Sponsors & Collaborators

• British Columbia Cancer Agency: lead
• BC Cancer Foundation: collaborator

Study Sites (1)

British Columbia Cancer Agency

Vancouver, British Columbia, V5Z1L3, Canada

RECRUITING

MeSH Terms

Conditions

Mesothelioma; Lung Neoplasms

Condition Hierarchy (Ancestors)

Adenoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Mesothelial; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Stephen Lam

  British Columbia Cancer Agency

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sharon Gee

CONTACT

604-675-8089; sgee@bccancer.bc.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 30, 2012
• First Posted: November 1, 2012
• Study Start: October 1, 2012
• Primary Completion: October 1, 2014
• Study Completion: December 1, 2014
• Last Updated: November 1, 2012

Record last verified: 2012-10

Locations

CA (1)