Early Diagnosis of Lung Cancer and Mesothelioma in Prior Asbestos Workers

NCT00188890 | Completed

• 1 other identifier: Asbestos Screening Study
• Study Type: observational
• Target: 1,452
• Locations: 1 country
• Sites: 1

Brief Summary

Occupational exposure to asbestos is known increase the risk of developing cancer of the lungs (bronchogenic carcinoma) or of the pleura (mesothelioma). Symptoms are subtle and non-specific, diagnosis is often late and the prognosis consequently is dismal. Currently there is no accepted non-invasive tool for the early diagnosis of mesothelioma or lung cancer in asbestos-exposed subjects. In the last decade, low-dose computed tomography (LDCT) has been successfully developed and validated for the early diagnosis of lung cancer in high-risk smokers. Malignant mesothelioma might, in an early stage, resemble a benign pleural plaque, which is a common finding after asbestos exposure. We target to develop low-dose CT as a tool to serially image the pleural plaques, quantify their individual and overall volume, compute the growth rate with time, and, as such, identify the presence of mesothelioma early, before symptoms occur.

Conditions

Lung Cancer; Mesothelioma

Keywords

Lung Cancer; Mesothelioma; Asbestos; Screening; Early Diagnosis

Study Arms (1)

1

prior occupational exposure at least 20 years ago to ASBESTOS and / or documented pleural plaques on a chest x-ray Must be 30 years of age or older. NO prior cancers, except non-melanic skin cancers

Eligibility Criteria

• Age: 30 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

prior exposure to asbestos and or documented pleural plaques

You may qualify if:

• prior asbestos exposure at least 20 years ago and/or documented pleural plaques (chest x-ray evidence)
• Resident of Ontario, Canada

You may not qualify if:

• prior cancer (except non-melanotic skin cancer)

Sponsors & Collaborators

• University Health Network, Toronto: lead

Study Sites (1)

Princess Margaret Hospital

Toronto, Ontario, Canada

Location

MeSH Terms

Conditions

Lung Neoplasms; Mesothelioma; Disease

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Adenoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms, Mesothelial; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Demetris Patsios, MD

  University Health Network, Toronto

  PRINCIPAL INVESTIGATOR

• Marc de Perrot, MD

  University Health Network, Toronto

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 12, 2005
• First Posted: September 16, 2005
• Study Start: March 1, 2005
• Primary Completion: July 3, 2019
• Study Completion: July 3, 2019
• Last Updated: October 7, 2019

Record last verified: 2019-10

Locations

CA (1)