Neurofibromatosis Type 1 Brain Tumor Genetic Risk

NCT01707836 | Completed

• 1 other identifier: 201208141
• Study Type: observational
• Target: 176
• Locations: 1 country
• Sites: 1

Brief Summary

This study will analyze DNA samples to determine associations between maternal and offspring genetic factors and pediatric brain tumor development in children with Neurofibromatosis Type 1. Participating families (mother, father, child) will be asked to complete a short questionnaire and provide DNA samples (either saliva or blood). The information gained from your participation may one day help doctors develop strategies to reduce brain tumor risk in individuals with NF1. Please note: there is no therapy associated with this study.

Conditions

Neurofibromatosis Type 1; Pediatric Brain Tumor

Outcome Measures

Primary Outcomes (1)

• Brain Tumor

  September 1, 2012-February 1, 2014

Study Arms (1)

Family

Families with a child with Neurofibromatosis Type 1 who has been diagnosed with a brain tumor.

Eligibility Criteria

• Age: Up to 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Families will be recruited from the Washingington University Neurofibromatosis-1 (NF1) Patient Registry Initiative (NPRI) and NF Center Clinic.

You may qualify if:

• Pediatric participant (born during 1994-2012) with NF1 and diagnosed with a brain tumor
• Biological mother or father (or full sibling if mother or father is unable to participate) able to participate
• All family members (pediatric participant, biological mother, and biological father or full sibling) must be willing to contribute a blood or saliva sample
• ability to understand consent forms

Sponsors & Collaborators

• Washington University School of Medicine: lead

Study Sites (1)

Washington University

St Louis, Missouri, 63130, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood or saliva samples

MeSH Terms

Conditions

Neurofibromatosis 1

Condition Hierarchy (Ancestors)

Neurofibromatoses; Neurofibroma; Nerve Sheath Neoplasms; Neoplasms, Nerve Tissue; Neoplasms by Histologic Type; Neoplasms; Neoplastic Syndromes, Hereditary; Neurocutaneous Syndromes; Nervous System Diseases; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Peripheral Nervous System Diseases; Neuromuscular Diseases; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• Kimberly J Johnson, PhD

  Washington University School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 12, 2012
• First Posted: October 16, 2012
• Study Start: October 1, 2012
• Primary Completion: May 8, 2017
• Study Completion: May 8, 2017
• Last Updated: May 9, 2017

Record last verified: 2017-05

Locations

US (1)