Key Insights

Highlights

Success Rate

87% trial completion (above average)

Published Results

15 trials with published results (19%)

Clinical Risk Assessment

Based on trial outcomes

Moderate Risk

Score: 50/100

Termination Rate

7.8%

6 terminated out of 77 trials

Success Rate

87.2%

+0.7% vs benchmark

Late-Stage Pipeline

5%

4 trials in Phase 3/4

Results Transparency

37%

15 of 41 completed with results

Key Signals

15 with results87% success

Data Visualizations

Phase Distribution

43Total
Not Applicable (13)
Early P 1 (1)
P 1 (10)
P 2 (15)
P 3 (2)
P 4 (2)

Trial Status

Completed41
Active Not Recruiting11
Unknown8
Recruiting7
Terminated6
Withdrawn2

Trial Success Rate

87.2%

Benchmark: 86.6%

Based on 41 completed trials

Clinical Trials (77)

Showing 20 of 20 trials
NCT06880991RecruitingPrimary

Development of Patient-Reported Outcome Measures Assessing Tumor Visibility and Appearance Concerns in Neurofibromatosis Type 1: A Qualitative Study

NCT00111384CompletedPrimary

Study of Disease Severity in Adults With Neurofibromatosis Type 1 (NF1)

NCT01362803Phase 1Active Not Recruiting

AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors

NCT06515860Active Not RecruitingPrimary

Neurofibromatosis Type 1 Tumor Early Detection Study

NCT00924196Active Not RecruitingPrimary

Natural History Study of Patients With Neurofibromatosis Type I

NCT06541847Phase 2RecruitingPrimary

A Phase 2, Open-Label Study to Evaluate the Safety and Effects of HLX-1502 in Patients With Neurofibromatosis Type 1

NCT03190915Phase 2Active Not Recruiting

Trametinib in Treating Patients With Relapsed or Refractory Juvenile Myelomonocytic Leukemia

NCT00314119CompletedPrimary

Natural History and Biology of Skin Neurofibromas in Neurofibromatosis Type 1

NCT03975829Phase 4Active Not Recruiting

Pediatric Long-Term Follow-up and Rollover Study

NCT02964884Phase 2Active Not RecruitingPrimary

Interventions for Reading Disabilities in NF1

NCT03871257Phase 3Active Not Recruiting

A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma

NCT07221331RecruitingPrimary

Prevalence, Clinical Characteristics, Progression, and Management of Neurofibromatosis Type 1 in Egypt (NF1-Egy)

NCT03050268Recruiting

Familial Investigations of Childhood Cancer Predisposition

NCT05309668Phase 1Active Not RecruitingPrimary

Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN

NCT06507748Not ApplicableRecruitingPrimary

A Study to Evaluate the Feasibility of a Physiologic Biomarker to Assess Pain and Other Sensory Problems Using Pupillometry in Participants With Neurofibromatosis Type 1 (NF1)

NCT05101148Phase 1Active Not RecruitingPrimary

Phase I Study to Assess the Effect of Food on the PK and Gastrointestinal Tolerability of Selumetinib in Adolescent Children With Neurofibromatosis Type 1 Related Plexiform Neurofibromas

NCT07564622Not Yet RecruitingPrimary

Gait in Young Children With NF1

NCT04763109Not ApplicableRecruitingPrimary

Identification of Pre-Malignant Lesions In Pediatric Patients With Neurofibromatosis Type 1 Using Novel Magnetic Resonance Imaging Techniques Paired With Artificial Intelligence

NCT05388370Active Not RecruitingPrimary

PASS of Paediatric Patients Initiating Selumetinib

NCT05954416Recruiting

FARD (RaDiCo Cohort) (RaDiCo-FARD)

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