Glycemic Response to High Amylose Rice

NCT01685879 | Completed

• 2 other identifiers: HARiceProject HAW00262H
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

Certain types of rice have more dietary fiber than others. This type of rice is known a "high amylose rice." This study hypothesizes that high-amylose rice, will decrease blood glucose and insulin responses after consumption compared to conventional rice in healthy adults, ages 18-40. Eighteen healthy men and women will participate in this study. This study will determine how high blood glucose and insulin values rise after eating a portion of rice. This study will also evaluate hunger ratings after consuming rice. The results of this study will help researchers better understand how diet can influence diabetes management.

Conditions

Diabetes Treatment (Pilot Study)

Keywords

postprandial glycemic response; postprandial insulin response; rice; appetite; hunger

Outcome Measures

Primary Outcomes (1)

• Blood Glucose response

  Evaluated changes in blood glucose after consuming a bolus of carbohydrate from rice or a standard glucose beverage.

  120 minutes

Secondary Outcomes (2)

• Insulin Response

  120 minutes

• Appetite Response

  120 minutes

Study Arms (4)

High Amylose Rice 1

EXPERIMENTAL

Test rice with high dietary fiber content

Other: Rice

High Amylose Rice 2

EXPERIMENTAL

Test rice with high dietary fiber content

Other: Rice

Control Rice

PLACEBO COMPARATOR

Rice portion that contains 50 g carbohydrate.

Other: Rice

Glucose beverage

PLACEBO COMPARATOR

Glucose beverage with 50 g carbohydrate

Other: Glucose Beverage

Interventions

Rice OTHER

Rice portion containing 50 g total carbohydrate

High Amylose Rice 1

Glucose Beverage OTHER

Glucose beverage that provides 50 g total carbohydrate.

Glucose beverage

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Gender: male or female
• Age 18-40 years old
• In good general health
• Habitual breakfast eater
• Able to fast for 12 hours
• Available 7:00am-9:30am on weekdays
• Willing to participate in study and complete 4 study visits within a 6-week period
• Capable of giving informed consent

You may not qualify if:

• Current smoker
• BMI \> 30 kg/m2
• Current use of medications that alter appetite (antidepressants, antibiotics, weight loss medications, or appetite suppressants)
• Current use of medications to control blood glucose, insulin or insulin receptors
• History of pre-diabetes, diabetes, hyperglycemia, hyperinsulinemia, gastrointestinal disease or surgery, or eating disorders
• Food allergy of any kind
• Vegetarian
• For females, pregnancy (current or within past 6 months) or lack of a regular menstrual cycle.
• History of bleeding or clotting disorders (e.g. hemophilia, thrombocytopenia, Vitamin K deficiency, liver failure)
• Current use of medications or supplements that may interfere with clotting and prolong bleeding time (e.g. aspirin, NSAIDS, coumadin, other anticoagulant therapy, herbal supplements including, but not limited to curcumin and flavonoids)
• Problems with vascular access or difficulty tolerating blood draws

Sponsors & Collaborators

• University of Hawaii: lead

Study Sites (1)

University of Hawaii at Manoa

Honolulu, Hawaii, 96822, United States

Location

Study Officials

• Maria Stewart, PhD

  University of Hawaii at Manoa

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: September 11, 2012
• First Posted: September 14, 2012
• Study Start: October 1, 2012
• Primary Completion: October 1, 2013
• Study Completion: January 1, 2014
• Last Updated: September 1, 2014

Record last verified: 2014-08

Locations

US (1)