The Effects of Brown Rice Compared to White Rice on Postprandial Changes in IL-6 and MDA Levels in Sedentary Workers

NCT06780618 | Recruiting

• 1 other identifier: 24-10-1628
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if brown rice and white rice affect oxidative stress and inflammation in office workers who don't exercise much. The main question it aims to answer is: Does eating brown rice change MDA and IL-6 levels differently than eating white rice in people who don't exercise much? Participants will: Be interviewed to collect personal data, medical history, lifestyle habits, and dietary patterns. Be measured to calculate Body Mass Index (BMI). Be interviewed to complete a questionnaire to assess their physical activity level in the past week. Be interviewed to record all food and beverages consumed in the past 24 hours. Blood samples will be drawn twice, before and after consuming the research meal. Be provided with a research meal consisting of rice (either brown or white), scrambled eggs, and tofu stew that must be finished within 15 to 20 minutes.

Conditions

Sedentary Employees; Postprandial Oxidation and inflammation

Keywords

brown rice; white rice; interleukin-6; malondialdehyde; sedentary; inflammation; oxidative stress; postprandial

Outcome Measures

Primary Outcomes (1)

• The Effects of Brown Rice Consumption Compared to White Rice on Postprandial Changes in Interleukin-6 and Malondialdehyde Levels in Sedentary Workers

  Enrollment process to fullfil sample size at 2 weeks. The intervention will be completed in 1 day.

Study Arms (2)

brown rice

ACTIVE COMPARATOR

Other: RICE

white rice

PLACEBO COMPARATOR

Other: rice wheat (placebo)

Interventions

RICE OTHER

150 g of brown rice from Aek Sibundong variant at once

brown rice

rice wheat (placebo) OTHER

150 g of white rice from Setra Ramos variant at once

white rice

Eligibility Criteria

• Age: 21 Years - 59 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy administrative employees,
• age 21-59 years,
• normal body mass index (18.5-22.9 kg/m2),
• low physical activity (≤600 METs minutes/week),
• assign for informed consent

You may not qualify if:

• being pregnant/breastfed/menopause,
• consumption of herbal medicines and/or supplements within 24 hours before data collection,
• having history of DM, CVD, cancer, and autoimmune disease,
• being vegan,
• smoking/alcohol drinking,
• allergic to research food's ingredients

Sponsors & Collaborators

• Indonesia University: lead

Study Sites (1)

Faculty of Medicine University of Indonesia

Jakarta, Jakarta Special Capital Region, Indonesia

RECRUITING

MeSH Terms

Conditions

Sedentary Behavior; Inflammation

Condition Hierarchy (Ancestors)

Behavior; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Wulandari Taradita, MD

  Department of Nutrition Faculty of Medicine University of Indonesia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Rizqa F Putri, MD

CONTACT

+62 81325090874; rizqafebriliany@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: January 13, 2025
• First Posted: January 17, 2025
• Study Start: January 6, 2025
• Primary Completion: March 31, 2025
• Study Completion: April 30, 2025
• Last Updated: January 24, 2025

Record last verified: 2025-01

Locations

ID (1)