Digestion of Foods Consumed in Africa

NCT03007368 | Completed

• 1 other identifier: 1104010761
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

As populations become urbanized in Africa, the change to a more Westernized diet has been associated with rise in obesity and related metabolic syndrome diseases. The current study shows that in the West African Sahel, these replacement starchy staple foods have fast gastric emptying compared to traditional sorghum and millet foods; and implies that the latter could be beneficial in lowering glycemic response, providing energy from a meal over a longer time, and providing a satiety effect. Knowledge of this attribute of sorghum and millet foods could be useful to improve their image in West African cities to increase their consumption and to improve markets for local smallholder farmers.

Conditions

Obesity and Other Hyperalimentation

Outcome Measures

Primary Outcomes (1)

• Gastric emptying

  Breath test was performed using 13C-octanoic acid mixed into test meals

  acute study, 4 hours after consumption of test food

Secondary Outcomes (1)

• Appetitive response

  acute study, 4 hours after consumption of test food

Study Arms (8)

Rice

EXPERIMENTAL

Cooked white rice and tomato-based sauce

Other: Rice

Potato

EXPERIMENTAL

Cooked white peeled potato and tomato-based sauce

Other: Potato

Pasta

EXPERIMENTAL

Cooked macaroni product and tomato-based sauce

Other: Pasta

Sorghum thick porridge

EXPERIMENTAL

Sorghum thick porridge and tomato-based sauce

Other: Sorghum thick porridge

Millet thick porridge

EXPERIMENTAL

Millet thick porridge and tomato-based sauce

Other: Millet thick porridge

Millet couscous

EXPERIMENTAL

Cooked millet couscous and tomato-based sauce

Other: Millet couscous

Millet thin porridge

EXPERIMENTAL

Millet thin porridge

Other: Millet thin porridge

Millet thin monikuru porridge

EXPERIMENTAL

Millet thin porridge containing cooked millet granules (monikuru)

Other: Millet thin monikuru porridge

Interventions

Rice OTHER

Different modern and traditional starch-based foods found in Bamako, Mali were tested for differences in gastric emptying rate and appetitive response.

Rice

Potato OTHER

Different modern and traditional starch-based foods found in Bamako, Mali were tested for differences in gastric emptying rate and appetitive response .

Potato

Pasta OTHER

Different modern and traditional starch-based foods found in Bamako, Mali were tested for differences in gastric emptying rate and appetitive response.

Pasta

Sorghum thick porridge OTHER

Different modern and traditional starch-based foods found in Bamako, Mali were tested for differences in gastric emptying rate and appetitive response.

Sorghum thick porridge

Millet thick porridge OTHER

Different modern and traditional starch-based foods found in Bamako, Mali were tested for differences in gastric emptying rate and appetitive response.

Millet thick porridge

Millet couscous OTHER

Different modern and traditional starch-based foods found in Bamako, Mali were tested for differences in gastric emptying rate and appetitive response.

Millet couscous

Millet thin porridge OTHER

Different modern and traditional starch-based foods found in Bamako, Mali were tested for differences in gastric emptying rate and appetitive response.

Millet thin porridge

Millet thin monikuru porridge OTHER

Different modern and traditional starch-based foods found in Bamako, Mali were tested for differences in gastric emptying rate and appetitive response.

Millet thin monikuru porridge

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Normal body mass index (18 kg/m2 ≤ BMI ≤ 25 kg/m2)

You may not qualify if:

• Under any medication
• History of any gastrointestinal disease or surgery
• Diabetes
• Smoker

Sponsors & Collaborators

• Purdue University: lead
• Baylor College of Medicine: collaborator

Related Publications (4)

• Ghoos YF, Maes BD, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ, Vantrappen G. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology. 1993 Jun;104(6):1640-7. doi: 10.1016/0016-5085(93)90640-x.

  PMID: 8500721 BACKGROUND

• Choi MG, Camilleri M, Burton DD, Zinsmeister AR, Forstrom LA, Nair KS. [13C]octanoic acid breath test for gastric emptying of solids: accuracy, reproducibility, and comparison with scintigraphy. Gastroenterology. 1997 Apr;112(4):1155-62. doi: 10.1016/s0016-5085(97)70126-4.

  PMID: 9097998 BACKGROUND

• Clegg ME, Shafat A. Procedures in the 13C octanoic acid breath test for measurement of gastric emptying: analysis using Bland-Altman methods. Scand J Gastroenterol. 2010 Aug;45(7-8):852-61. doi: 10.3109/00365521.2010.483740.

  PMID: 20443742 BACKGROUND

• Schoeller DA, Klein PD, Watkins JB, Heim T, MacLean WC Jr. 13C abundances of nutrients and the effect of variations in 13C isotopic abundances of test meals formulated for 13CO2 breath tests. Am J Clin Nutr. 1980 Nov;33(11):2375-85. doi: 10.1093/ajcn/33.11.2375.

  PMID: 6776794 BACKGROUND

MeSH Terms

Conditions

Obesity

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 1, 2016
• First Posted: January 2, 2017
• Study Start: March 1, 2012
• Primary Completion: April 1, 2013
• Study Completion: May 1, 2013
• Last Updated: January 2, 2017

Record last verified: 2016-12

Data Sharing

• IPD Sharing: Will not share