Neuropsychopathological Study of Autism

NCT01677663 | Unknown DMC

• 1 other identifier: 201103003RB
• Study Type: observational
• Target: 350
• Locations: 1 country
• Sites: 1

Brief Summary

Autism or autism spectrum disorder (ASD) is a relatively common (0.3% in Taiwan), multi-factorial, genetically and clinically heterogeneous, childhood-onset neurodevelopmental disorder. Due to its high heritability and severe long-term impairment without available laboratory diagnosis, effective prevention or treatment, this disastrous disease has been prioritized for molecular genetic studies. Recent CNVs investigation to identify rare variants and GWA study with endophenotype approaches are promising strategies to identify common genetic variants. In addition to intermediate phenotypes such as head circumstance, speech delay, social impairments and stereotyped behaviors, evidence has demonstrated that neuropsychology and neuroimages may be useful endophenotypes for autism. Dlgap2, Fbxo25, and Arhgef10 knoutout mice generated from our previous CNV results will be characterized.

Conditions

Autism

Keywords

autism; clinical phenotypes; neuropsychology; imaging endophenotypes; family-based cohort; knoutout mice

Eligibility Criteria

• Age: 3 Years - 25 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The sample will consist of 350 probands with ASD, aged 3-25.

You may qualify if:

• subjects have a clinical diagnosis of autistic disorder or Asperger disorder defined by the DSM-IV and ICD-10;
• their ages range from 3 to 25 when we conduct the study;
• subjects have at least one biological parent;
• both parents of the subjects are Han Chinese;
• subjects and their biological parents (and siblings if any) consent to participate in this study.

You may not qualify if:

• if they currently meet criteria or have a history of DSM-IV Schizophrenia, Schizoaffective Disorder, or Organic Psychosis.

Sponsors & Collaborators

• National Taiwan University Hospital: lead
• National Taiwan University: collaborator

Study Sites (1)

National Taiwan Univeristy Hospital

Taipei, Taiwan

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

The subjects will receive blood withdrawal. The blood sample will be used for establishing lymphoblastoid cell lines, which will be used for molecular genetic experiments.

MeSH Terms

Conditions

Autistic Disorder

Condition Hierarchy (Ancestors)

Autism Spectrum Disorder; Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Susan Shur-Fen Gau, MD, PhD

  National Taiwan University Hospital & College of Medicine

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Susan Shur-Fen Gau, MD, PhD

CONTACT

886-2-23123456; gaushufe@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: FAMILY BASED
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Susan Shur-Fen Gau

Study Record Dates

• First Submitted: August 30, 2012
• First Posted: September 3, 2012
• Study Start: August 1, 2011
• Study Completion: July 1, 2016
• Last Updated: September 3, 2012

Record last verified: 2012-08

Locations

TW (1)