ASIAN HF Registry, A Prospective Observational Study

NCT01633398 | Completed Results

• 1 other identifier: ASIAN HF Registry
• Study Type: observational
• Target: 6,329
• Locations: 11 countries
• Sites: 11

Brief Summary

The ASIAN HF Registry is the first prospective multinational Asian registry of patients with symptomatic HF (stage C) including both HFrEF (ejection fraction \<40%) and HFpEF (ejection fraction ≥50%), with the broad purpose of determining the mortality (incidence) burden of HF in Asian patients, and more specifically to define the burden and risk factors of Sudden Cardiac Deaths (SCD), as well as the sociocultural barriers to preventive device therapy. The study further aim to study the genetic variants associated with HFrEF versus HFpEF in our large Asian cohort. This proposed registry is expected to advance fundamental understanding of the burden and predictors of preventable death among Asian patients with HF. The knowledge gained will be critical for guiding resource allocation and planning preventive strategies to address the unmet and growing clinical needs of patients with cardiovascular disease in Asia.

Conditions

Heart Failure

Keywords

Heart Failure; HF

Outcome Measures

Primary Outcomes (1)

• All Cause and Cause-specific Death

  The incidence of all-cause and cause-specific deaths among Asian patients with HF.

  2 years follow up

Secondary Outcomes (1)

• Sudden Cardiac Death

  2 years follow up

Interventions

Saliva Genetic testing GENETIC

To compare the genetic variants between the two phenotypes of reduced versus preserved ejection fraction (HFrEF versus HFpEF)

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This is a prospective, observational, multinational, multicenter Asian registry of patients with Stage C HF, including both HFrEF (ejection fraction \<40%) and HFpEF (ejection fraction ≥50%). This study population (Stage C HF) was selected in recognition of current recommendations emphasizing that HF is a progressive, staged disease.The HFrEF population was defined based on a recent meta-analysis showing that risk of death in HF increases particularly as ejection fraction falls below 40%. The HFpEF population was defined according to current guidelines. Patients with an ejection fraction in the range of 40% to 50% represent an intermediate group which was not included since we aimed to study distinct clinical phenotypes.

You may qualify if:

• Adults (\>18 years)
• Symptomatic HF (Stage C HF regardless of functional status). Patients should have a current diagnosis of symptomatic HF within 6 months of an episode of decompensated heart failure\*, which either: (a) resulted in a hospital admission (primary diagnosis) or b) was treated in out-patient clinic
• Left ventricular ejection fraction \<40% (HFrEF) or left ventricular ejection fraction ≥50% (HFpEF) on baseline echocardiography
• Available for follow-up over 3 years

You may not qualify if:

• Severe valve disease as the primary cause of HF
• For the HFpEF population: a documented history of reduced ejection fraction (\<50%) at any time prior to recruitment, In other words, patients with current HFpEF who previously had HFrEF will be excluded.
• Life threatening co-morbidity with life expectancy of \<1 year
• Unable or unwilling to give consent
• Concurrent participation in a clinical therapeutic trial which requires patient consent

Sponsors & Collaborators

• Carolyn Lam: lead
• Boston Scientific Corporation: collaborator
• Bayer: collaborator
• National Medical Research Council (NMRC), Singapore: collaborator
• Agency for Science, Technology and Research (A*STAR): collaborator

Study Sites (11)

Zhongshan Hospital Fudan University

Beijing, China

Location

The Chinese University of Hong Kong

Hong Kong, Hong Kong

Location

Medanta The Medicity

New Delhi, India

Location

National Cardiovascular Centre Harapan Kita Hospital

Jakarta, Indonesia

Location

National Cerebral and Cardiovascular Center

Tokyo, Japan

Location

Institut Jantung Negara

Kuala Lumpur, Malaysia

Location

Manila Doctors Hospital

Manila, Philippines

Location

National University Heart Center

Singapore, 119228, Singapore

Location

Korea University Anam Hospital

Seoul, South Korea

Location

Mackay Memorial Hospital

Taipei, Taiwan

Location

Ramathibodi Hospital

Bangkok, Thailand

Location

Related Publications (18)

• Ng TP, Niti M. Trends and ethnic differences in hospital admissions and mortality for congestive heart failure in the elderly in Singapore, 1991 to 1998. Heart. 2003 Aug;89(8):865-70. doi: 10.1136/heart.89.8.865.

  PMID: 12860859 BACKGROUND

• Hunt SA, Abraham WT, Chin MH, Feldman AM, Francis GS, Ganiats TG, Jessup M, Konstam MA, Mancini DM, Michl K, Oates JA, Rahko PS, Silver MA, Stevenson LW, Yancy CW; American College of Cardiology Foundation; American Heart Association. 2009 Focused update incorporated into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation. J Am Coll Cardiol. 2009 Apr 14;53(15):e1-e90. doi: 10.1016/j.jacc.2008.11.013. No abstract available.

  PMID: 19358937 BACKGROUND

• Teng TK, Lam CSP; ASIAN-HF Executive Committee and Investigators. Comprehensive Introduction to ASIAN-HF Registry. JACC Asia. 2025 Sep;5(9):1206-1216. doi: 10.1016/j.jacasi.2025.05.020. Epub 2025 Jul 29.

  PMID: 40736437 DERIVED

• Aung T, Qin Y, Tay WT, Binte Salahudin Bamadhaj NS, Chandramouli C, Ouwerkerk W, Tromp J, Anand I, Richards AM, Hung CL, Teramoto K, Katherine Teng TH, Lam CSP. Prevalence and Prognostic Significance of Frailty in Asian Patients With Heart Failure: Insights From ASIAN-HF. JACC Asia. 2021 Dec 7;1(3):303-313. doi: 10.1016/j.jacasi.2021.09.006. eCollection 2021 Dec.

  PMID: 36341220 DERIVED

• Tay WT, Teng TK, Simon O, Ouwerkerk W, Tromp J, Doughty RN, Richards AM, Hung CL, Qin Y, Aung T, Anand I, Lam CSP; ASIAN-HF Investigators. Readmissions, Death and Its Associated Predictors in Heart Failure With Preserved Versus Reduced Ejection Fraction. J Am Heart Assoc. 2021 Nov 16;10(22):e021414. doi: 10.1161/JAHA.121.021414. Epub 2021 Oct 20.

  PMID: 34666509 DERIVED

• Teng TK, Tay WT, Richards AM, Chew TSM, Anand I, Ouwerkerk W, Chandramouli C, Huang W, Lawson CA, Kadam UT, Yap J, Lim S, Hung CL, MacDonald MR, Loh SY, Shimizu W, Tromp J, Lam CSP; ASIAN-HF investigatorsdouble dagger. Socioeconomic Status and Outcomes in Heart Failure With Reduced Ejection Fraction From Asia. Circ Cardiovasc Qual Outcomes. 2021 Apr;14(4):e006962. doi: 10.1161/CIRCOUTCOMES.120.006962. Epub 2021 Mar 24.

  PMID: 33757307 DERIVED

• Chyou JY, Tay WT, Anand IS, Teng TK, Yap JJL, MacDonald MR, Chopra V, Loh SY, Shimizu W, Abidin IZ; ASIAN-HF Investigators; Richards AM, Butler J, Lam CSP. Electroanatomic Ratios and Mortality in Patients With Heart Failure: Insights from the ASIAN-HF Registry. J Am Heart Assoc. 2021 Mar 16;10(6):e017932. doi: 10.1161/JAHA.120.017932. Epub 2021 Mar 13.

  PMID: 33719492 DERIVED

• Huang W, Teng TK, Tay WT, Richards AM, Kadam U, Lawson CA, Shimizu W, Loh SY, Anand I, Lam CSP. Patient-reported outcomes in heart failure with preserved vs. reduced ejection fraction: focus on physical independence. ESC Heart Fail. 2020 Oct;7(5):2051-2062. doi: 10.1002/ehf2.12950. Epub 2020 Aug 30.

  PMID: 32862518 DERIVED

• MacDonald MR, Tay WT, Teng TK, Anand I, Ling LH, Yap J, Tromp J, Wander GS, Naik A, Ngarmukos T, Siswanto BB, Hung CL, Richards AM, Lam CSP; ASIAN-F investigators dagger; ASIAN-F investigators<xref ref-type="author-note" rid="jah34461-note-1001">^dagger</xref>. Regional Variation of Mortality in Heart Failure With Reduced and Preserved Ejection Fraction Across Asia: Outcomes in the ASIAN-HF Registry. J Am Heart Assoc. 2020 Jan 7;9(1):e012199. doi: 10.1161/JAHA.119.012199. Epub 2019 Dec 19.

  PMID: 31852421 DERIVED

• Chandramouli C, Tay WT, Bamadhaj NS, Tromp J, Teng TK, Yap JJL, MacDonald MR, Hung CL, Streng K, Naik A, Wander GS, Sawhney J, Ling LH, Richards AM, Anand I, Voors AA, Lam CSP; ASIAN-HF Investigators. Association of obesity with heart failure outcomes in 11 Asian regions: A cohort study. PLoS Med. 2019 Sep 24;16(9):e1002916. doi: 10.1371/journal.pmed.1002916. eCollection 2019 Sep.

  PMID: 31550265 DERIVED

• Yap J, Tay WT, Teng TK, Anand I, Richards AM, Ling LH, MacDonald MR, Chandramouli C, Tromp J, Siswanto BB; ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) Registry Investigators; Zile M, McMurray J, Lam CSP. Association of Diabetes Mellitus on Cardiac Remodeling, Quality of Life, and Clinical Outcomes in Heart Failure With Reduced and Preserved Ejection Fraction. J Am Heart Assoc. 2019 Sep 3;8(17):e013114. doi: 10.1161/JAHA.119.013114. Epub 2019 Aug 21.

  PMID: 31431116 DERIVED

• Tromp J, Lim SL, Tay WT, Teng TK, Chandramouli C, Ouwerkerk W, Wander GS, Sawhney JPS, Yap J, MacDonald MR, Ling LH, Sattar N, McMurray JJV, Richards AM, Anand I, Lam CSP; ASIAN-HF Investigators. Microvascular Disease in Patients With Diabetes With Heart Failure and Reduced Ejection Versus Preserved Ejection Fraction. Diabetes Care. 2019 Sep;42(9):1792-1799. doi: 10.2337/dc18-2515. Epub 2019 Jul 10.

  PMID: 31292141 DERIVED

• Chandramouli C, Teng TK, Tay WT, Yap J, MacDonald MR, Tromp J, Yan L, Siswanto B, Reyes EB, Ngarmukos T, Yu CM, Hung CL, Anand I, Richards AM, Ling LH, Regensteiner JG, Lam CSP; ASIAN-HF Investigators. Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry. Eur J Heart Fail. 2019 Mar;21(3):297-307. doi: 10.1002/ejhf.1358. Epub 2018 Dec 10.

  PMID: 30548089 DERIVED

• Teng TK, Tromp J, Tay WT, Anand I, Ouwerkerk W, Chopra V, Wander GS, Yap JJ, MacDonald MR, Xu CF, Chia YM, Shimizu W; ASIAN-HF investigators; Richards AM, Voors A, Lam CS. Prescribing patterns of evidence-based heart failure pharmacotherapy and outcomes in the ASIAN-HF registry: a cohort study. Lancet Glob Health. 2018 Sep;6(9):e1008-e1018. doi: 10.1016/S2214-109X(18)30306-1.

  PMID: 30103979 DERIVED

• Tromp J, Tay WT, Ouwerkerk W, Teng TK, Yap J, MacDonald MR, Leineweber K, McMurray JJV, Zile MR, Anand IS, Richards AMR, Lam CSP; ASIAN-HF authors. Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry. PLoS Med. 2018 Mar 27;15(3):e1002541. doi: 10.1371/journal.pmed.1002541. eCollection 2018 Mar.

  PMID: 29584721 DERIVED

• Chia YMF, Teng TK, Tan ESJ, Tay WT, Richards AM, Chin CWL, Shimizu W, Park SW, Hung CL, Ling LH, Ngarmukos T, Omar R, Siswanto BB, Narasimhan C, Reyes EB, Yu CM, Anand I, MacDonald MR, Yap J, Zhang S, Finkelstein EA, Lam CSP. Disparity Between Indications for and Utilization of Implantable Cardioverter Defibrillators in Asian Patients With Heart Failure. Circ Cardiovasc Qual Outcomes. 2017 Nov;10(11):e003651. doi: 10.1161/CIRCOUTCOMES.116.003651.

  PMID: 29150533 DERIVED

• Lam CS, Teng TK, Tay WT, Anand I, Zhang S, Shimizu W, Narasimhan C, Park SW, Yu CM, Ngarmukos T, Omar R, Reyes EB, Siswanto BB, Hung CL, Ling LH, Yap J, MacDonald M, Richards AM. Regional and ethnic differences among patients with heart failure in Asia: the Asian sudden cardiac death in heart failure registry. Eur Heart J. 2016 Nov 1;37(41):3141-3153. doi: 10.1093/eurheartj/ehw331. Epub 2016 Aug 7.

  PMID: 27502121 DERIVED

• Lam CS, Anand I, Zhang S, Shimizu W, Narasimhan C, Park SW, Yu CM, Ngarmukos T, Omar R, Reyes EB, Siswanto B, Ling LH, Richards AM. Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) registry. Eur J Heart Fail. 2013 Aug;15(8):928-36. doi: 10.1093/eurjhf/hft045. Epub 2013 Apr 7.

  PMID: 23568645 DERIVED

MeSH Terms

Conditions

Heart Failure

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Results Point of Contact

• Title: Carolyn Lam
• Organization: National University Health System, Singapore

carolyn.lam@duke-nus.edu.sg

(65)67048965

Study Officials

• Carolyn Lam, M.D.

  National University Heart Center (NUHC)

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restriction Type: OTHER
• Restrictive Agreement: Yes

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Senior Consultant, National Heart Centre Singapore and Professor, Duke-National University of Singapore

Study Record Dates

• First Submitted: June 27, 2012
• First Posted: July 4, 2012
• Study Start: September 1, 2012
• Primary Completion: March 6, 2020
• Study Completion: March 6, 2020
• Last Updated: July 14, 2021
• Results First Posted: July 14, 2021

Record last verified: 2021-07

Locations

MY (1); ID (1); IN (1); CN (1); HK (1); JP (1); KR (1); TW (1); TH (1); SG (1); PH (1)