Study of Modified Constraint-Induced Aphasia Therapy Schedule to Treat Patients Following Sub-acute Stroke
MCIAT
Constraint-Induced Aphasia Therapy Following Sub-acute Stroke: A Modified Therapy Schedule
1 other identifier
interventional
100
1 country
1
Brief Summary
The purpose of this study is to assess the feasibility of modified Constraint-Induced Aphasia Therapy (CIAT) in the early sub-acute stage and to examine the efficacy of modified CIAT versus standard treatment with the same intensity of intervention.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Aug 2004
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2004
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedFirst Submitted
Initial submission to the registry
June 15, 2012
CompletedFirst Posted
Study publicly available on registry
June 21, 2012
CompletedJune 21, 2012
June 1, 2012
6.2 years
June 15, 2012
June 19, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Change of aphasia and aphasic syndromes by Aachen Aphasia Test (AAT)
pretreatment and 4 weeks
change from pretreatment in Aachen Aphasia Test at 8 weeks
pretreatment and 8 weeks
change from pretreatment in Aachen Aphasia Test at 1 year
pretreatment and 1 year
Secondary Outcomes (3)
Change of Communicative Activity (CAL)
pretreatment and 4 weeks
change from pretreatment in communication activity (CAL)at 8 weeks
pretreatment and 8 weeks
Change from pretreatment in communication activity (CAL)at 1 year
pretreatment and 1 year
Study Arms (2)
CIAT-Group
EXPERIMENTALPatients received a modified constraint-induced therapy schedule
standard treatment group
ACTIVE COMPARATORpatients received a standard aphasia therapy
Interventions
2 hours of training over 15 days
Eligibility Criteria
You may qualify if:
- clinical diagnosis of first-ever stroke
- aphasia in sub-acute stage
- german speakers
You may not qualify if:
- presence of residual aphasia
- dysarthria and apraxia of speech
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
NRZ Median Klinik
Magdeburg, Germany, 39120, Germany
Related Publications (1)
Sickert A, Anders LC, Munte TF, Sailer M. Constraint-induced aphasia therapy following sub-acute stroke: a single-blind, randomised clinical trial of a modified therapy schedule. J Neurol Neurosurg Psychiatry. 2014 Jan;85(1):51-5. doi: 10.1136/jnnp-2012-304297. Epub 2013 Jul 4.
PMID: 23828834DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Almut A Sickert, PhD
NRZ Median Klinik Magdeburg
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 15, 2012
First Posted
June 21, 2012
Study Start
August 1, 2004
Primary Completion
October 1, 2010
Study Completion
December 1, 2011
Last Updated
June 21, 2012
Record last verified: 2012-06