NCT01583907

Brief Summary

The investigators aim to asses the effect of dieto-therapy and of nutritional counseling on the nutritional status, body growth and tolerance acquisition in children with cow's milk allergy.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
70

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Mar 2012

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2012

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

April 5, 2012

Completed
19 days until next milestone

First Posted

Study publicly available on registry

April 24, 2012

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2013

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2014

Completed
Last Updated

April 25, 2012

Status Verified

April 1, 2012

Enrollment Period

1 year

First QC Date

April 5, 2012

Last Update Submit

April 24, 2012

Conditions

Keywords

cow's milk allergy

Outcome Measures

Primary Outcomes (1)

  • Change in anthropometric indices after dieto-therapy intervention and nutritional counseling in children with cow's milk allergy

    Anthropometric indices (z-score for weight, length and head circumference) will be collected at the enrolment (T0) and after 2 (T1), 4 (T2) and 6 months (T3) by experienced nurse unaware to of the study aims. Dietary intake will be assessed by a 3-day diary at T0 and at T3. The nutrient intake will be analyzed using a specific software. The following laboratory measurements will be also analyzed at T0 and at T3: haemoglobin, albumin, total cholesterol, triglycerides, calcium, phosphorus, zinc, fatty acids.

    1 year

Secondary Outcomes (2)

  • Change in nutritional status after dieto-therapy intervention and nutritional counseling in children with cow's milk allergy

    1 year

  • Change in time of tolerance acquisition after dieto-therapy intervention in children with cow's milk allergy.

    1 year

Study Arms (1)

different dietotherapy strategies

Eligibility Criteria

Age6 Months - 36 Months
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)
Sampling MethodProbability Sample
Study Population

children with a sure diagnosis of food allergy

You may qualify if:

  • Patients 6-36 months of age with a suspected FA

You may not qualify if:

  • Unconfirmed diagnosis of FA
  • Prematurity
  • Systemic disease
  • Renal failure
  • Neurological impairment
  • Active tuberculosis
  • Autoimmune diseases
  • Immunodeficiency
  • Chronic inflammatory bowel diseases
  • Celiac disease
  • Cystic fibrosis
  • Metabolic or endocrine diseases
  • Malignancy
  • Malformation of the gastrointestinal or the urinary tract

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

university of naples federico II

Naples, Naples, 80131, Italy

RECRUITING

Biospecimen

Retention: SAMPLES WITHOUT DNA

blood sampling to measure laboratory parameters useful to asses nutritional status

MeSH Terms

Conditions

Food HypersensitivityMilk Hypersensitivity

Condition Hierarchy (Ancestors)

Hypersensitivity, ImmediateHypersensitivityImmune System Diseases

Central Study Contacts

roberto berni canani, MD,PhD

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD, PhD

Study Record Dates

First Submitted

April 5, 2012

First Posted

April 24, 2012

Study Start

March 1, 2012

Primary Completion

March 1, 2013

Study Completion

March 1, 2014

Last Updated

April 25, 2012

Record last verified: 2012-04

Locations