Training, Detraining, Retraining and Glycemic Control in Patients With Type 2 Diabetes

NCT01580475 | Completed

• 2 other identifiers: EPEAEK - PYTHAGORAS II1328-5 PYTHAGORAS II
• Study Type: interventional
• Target: 13
• Locations: 1 country
• Sites: 1

Brief Summary

• This study examine the effects of training, detraining and retraining, using a combined strength and aerobic exercise program, on physiological parameters in patients with type 2 diabetes.
• Thirteen women with type 2 diabetes followed a supervised aerobic and strength training program for 9 months, interrupted for 3 months (detraining) and resumed again for a period of 9 months (retraining).
• Training improved body mass index, fasting plasma glucose,postprandial glucose, glycosylated hemoglobin, peak oxygen consumption,power output and total muscle strength. Detraining reversed PPG, HbA1C and physical fitness parameters. Resumption of training however, improved further the initial training adaptations.
• Diabetic patients should follow a regular and uninterrupted exercise program throughout life in order to control glucose metabolism and improve health status.

Conditions

Type 2 Diabetes

Keywords

glycemic control,; exercise training,; detraining,; retraining,; body composition,; strength and fitness

Outcome Measures

Primary Outcomes (1)

• Changes from baseline in glycemic control measurements (follow-up for 21 months) at training (9 months), detraining (3 months) and retraining (9 months)

  Glycemic control was evaluated by the measurement of fasting plasma glucose (FPG), postprandial glucose (PPG) and glycosylated hemoglobin (HbA1C). PPG was calculated by the mean of four values measured at the first week of every period (baseline, 9th, 12th and 21st months).

  Changes from baseline in HbA1C, FPG and PPG at training (9 months), detraining (11 months) and retraining (21 months)

Secondary Outcomes (3)

• Evaluation of body composition

  Changes from baseline in body composition assessment at training (9 months), detraining (3 months), retraining (9 months)

• Peak oxygen consumption (VO2peak)

  Changes from baseline in VO2peak at training (9 months), detraining (11 months) and retraining (21 months)

• Measurement of muscular strength in patients with type 2 diabetes

  Changes from baseline in muscular strength at training (9 months), detraining (11 months) and retraining (21 months)

Study Arms (1)

Lifestyle (exercise training)

EXPERIMENTAL

Training, detraining and retraining

Other: Training - detraining - retraining

Interventions

Training - detraining - retraining OTHER

Thirteen women with type 2 diabetes followed a supervised aerobic and strength training program for 9 months, interrupted for 3 months (detraining) and resumed again for a period of 9 months (retraining).

Lifestyle (exercise training)

Eligibility Criteria

• Age: 45 Years - 65 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Type 2 diabetes
• without micro- and macroangiopathy

You may not qualify if:

• type 1 diabetes
• cardiovascular disease,
• confirmed retinopathy/nephropathy/neuropathy,
• uncontrolled diabetes mellitus (HbA1c\>10%).

Sponsors & Collaborators

• Democritus University of Thrace: lead
• Aristotle University Of Thessaloniki: collaborator

Study Sites (1)

Savvas P. Tokmakidis

Komotini, 691 00, Greece

Location

Related Publications (6)

• Tokmakidis SP, Zois CE, Volaklis KA, Kotsa K, Touvra AM. The effects of a combined strength and aerobic exercise program on glucose control and insulin action in women with type 2 diabetes. Eur J Appl Physiol. 2004 Aug;92(4-5):437-42. doi: 10.1007/s00421-004-1174-6.

  PMID: 15232701 BACKGROUND

• Tokmakidis SP, Volaklis KA. Training and detraining effects of a combined-strength and aerobic exercise program on blood lipids in patients with coronary artery disease. J Cardiopulm Rehabil. 2003 May-Jun;23(3):193-200. doi: 10.1097/00008483-200305000-00006.

  PMID: 12782903 BACKGROUND

• Tokmakidis SP, Spassis AT, Volaklis KA. Training, detraining and retraining effects after a water-based exercise program in patients with coronary artery disease. Cardiology. 2008;111(4):257-64. doi: 10.1159/000127737. Epub 2008 Apr 23.

  PMID: 18434735 BACKGROUND

• American College of Sports Medicine; American Dietetic Association; Dietitians of Canada. Joint Position Statement: nutrition and athletic performance. American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada. Med Sci Sports Exerc. 2000 Dec;32(12):2130-45. doi: 10.1097/00005768-200012000-00025.

  PMID: 11128862 BACKGROUND

• Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, Roubenoff R, Tucker KL, Nelson ME. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care. 2002 Dec;25(12):2335-41. doi: 10.2337/diacare.25.12.2335.

  PMID: 12453982 BACKGROUND

• Dunstan DW, Daly RM, Owen N, Jolley D, De Courten M, Shaw J, Zimmet P. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care. 2002 Oct;25(10):1729-36. doi: 10.2337/diacare.25.10.1729.

  PMID: 12351469 BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Savvas P. Tokmakidis, PhD

  Democritus University of Thrace

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 18, 2012
• First Posted: April 19, 2012
• Study Start: September 1, 2008
• Primary Completion: September 1, 2008
• Study Completion: June 1, 2010
• Last Updated: April 19, 2012

Record last verified: 2012-04

Locations

GR (1)