Effects of Different Types of Exercise in Type 2 Diabetes

NCT01182948 | Completed

• 1 other identifier: CE1578
• Study Type: interventional
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purposes of this study are: a) to compare the effects of supervised programs of aerobic training or resistance training on the metabolic control of type 2 diabetes; b) to investigate some potential pathophysiologic and molecular mechanisms underlying these effects; c) to assess whether some changes may persist over time after termination of the supervised programs.

Conditions

Type 2 Diabetes

Keywords

aerobic training; resistance training; type 2 diabetes; therapy

Outcome Measures

Primary Outcomes (1)

• Change in haemoglobin A1c (HbA1c) levels

  The measurement of HbA1c is carried out with a DCCT (Diabetes Control and Complications Trial)-aligned method.

  4 months

Secondary Outcomes (22)

• Change in body weight

  4 months

• Change in body composition

  4 months

• Change in fasting plasma glucose levels

  4 months

• Change in total cholesterol levels

  4 months

• Change in HDL-cholesterol levels

  4 months

Study Arms (2)

Aerobic Exercise

EXPERIMENTAL

The aerobic training group will use cardiovascular training devices.

Behavioral: Aerobic Training

Resistance Exercise

EXPERIMENTAL

The resistance training group will perform exercises on weight machines and free weights.

Behavioral: Resistance Training

Interventions

Aerobic Training BEHAVIORAL

The aerobic training group will exercise on cardiovascular training equipment. The workload will be gradually increased up to 60% of the reserve heart rate. Subjects will exercise 3 times per week for 60 min in the Fitness Centre of the Exercise and Sport Science School. Training will be carried out in small groups, under the supervision of personal trainers. During the study subjects will be instructed to follow an isocaloric diet.

Aerobic Exercise

Resistance Training BEHAVIORAL

The resistance training group will perform different exercises on weight machines and free weights to exercise upper and lower extremity muscles. Participants will perform 8-10 different exercises each session, alternating abdominal, upper and lower extremity exercises. Subjects will exercise 3 times per week for 60 min in the Fitness Centre of the Exercise and Sport Science School. Training will be carried out in small groups, under the supervision of personal trainers. During the study subjects will be instructed to follow an isocaloric diet.

Resistance Exercise

Eligibility Criteria

• Age: 40 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI between 24-36 kg/m2;
• HbA1c between 6.5-9.0%;
• diabetes diagnosis must have been made at least 1 yr previously;
• admitted diabetes treatments will be diet and oral hypoglycemic agents;
• baseline physical activity, estimated by the IPAQ questionnaire, lower than 1000 MET min per week;
• baseline body weight stable (changes lower than 2 kg in the last 2 months).

You may not qualify if:

• moderate-severe somatic or autonomic neuropathy;
• coronary heart disease;
• peripheral or cerebral vascular disease;
• preproliferative or proliferative retinopathy or chronic renal failure (serum creatinine \>1.4 mg/dl in females; \>1.5 mg/dl in males);
• therapy with beta-blocker drugs;
• smokers;
• acute clinically significant intercurrent diseases;
• inability to perform the scheduled physical activity programs.

Sponsors & Collaborators

• Universita di Verona: lead

Related Publications (5)

• Dauriz M, Olioso D, Moghetti P. Response to Comment on Olioso D, et al. "Effect of Aerobic and Resistance Training on Circulating Micro-RNA Expression Profile in Subjects with Type 2 Diabetes". J Clin Endocrinol Metab. 2020 Apr 1;105(4):dgaa068. doi: 10.1210/clinem/dgaa068. No abstract available.

  PMID: 32080720 DERIVED

• Olioso D, Dauriz M, Bacchi E, Negri C, Santi L, Bonora E, Moghetti P. Effects of Aerobic and Resistance Training on Circulating Micro-RNA Expression Profile in Subjects With Type 2 Diabetes. J Clin Endocrinol Metab. 2019 Apr 1;104(4):1119-1130. doi: 10.1210/jc.2018-01820.

  PMID: 30445461 DERIVED

• Bellavere F, Cacciatori V, Bacchi E, Gemma ML, Raimondo D, Negri C, Thomaseth K, Muggeo M, Bonora E, Moghetti P. Effects of aerobic or resistance exercise training on cardiovascular autonomic function of subjects with type 2 diabetes: A pilot study. Nutr Metab Cardiovasc Dis. 2018 Mar;28(3):226-233. doi: 10.1016/j.numecd.2017.12.008. Epub 2018 Jan 2.

  PMID: 29402509 DERIVED

• Bacchi E, Negri C, Trombetta M, Zanolin ME, Lanza M, Bonora E, Moghetti P. Differences in the acute effects of aerobic and resistance exercise in subjects with type 2 diabetes: results from the RAED2 Randomized Trial. PLoS One. 2012;7(12):e49937. doi: 10.1371/journal.pone.0049937. Epub 2012 Dec 5.

  PMID: 23227155 DERIVED

• Bacchi E, Negri C, Zanolin ME, Milanese C, Faccioli N, Trombetta M, Zoppini G, Cevese A, Bonadonna RC, Schena F, Bonora E, Lanza M, Moghetti P. Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study). Diabetes Care. 2012 Apr;35(4):676-82. doi: 10.2337/dc11-1655. Epub 2012 Feb 16.

  PMID: 22344613 DERIVED

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Paolo Moghetti, MD.,Ph.D.

  Universita di Verona

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Endocrinology

Study Record Dates

• First Submitted: August 16, 2010
• First Posted: August 17, 2010
• Study Start: January 1, 2009
• Primary Completion: December 1, 2010
• Last Updated: August 25, 2011

Record last verified: 2011-08