The Effect of Vinegar on Glucose and Lipid Metabolism in Subjects With Impaired Glucose Tolerance or Type 2 Diabetes

NCT02309424 | Completed

• 1 other identifier: 167/11-06-08
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

This open, randomized, cross-over, placebo-controlled study aims to investigate the effects of vinegar on glucose metabolism, endothelial function and circulating lipid levels in subjects with impaired glucose tolerance or type 2 diabetes, using the arteriovenous difference technique.

Conditions

Type 2 Diabetes

Outcome Measures

Primary Outcomes (1)

• Muscle glucose uptake following meal ingestion (area under the glucose uptake versus time curve-AUC)

  0, 30, 60, 90, 120, 180, 240, 300 min postmeal

Secondary Outcomes (7)

• Plasma glucose levels following meal ingestion (area under the plasma concentration versus time curve-AUC)

  0, 30, 60, 90, 120, 180, 240, 300 min postmeal

• Plasma insulin levels following meal ingestion (area under the plasma concentration versus time curve-AUC)

  0, 30, 60, 90, 120, 180, 240, 300 min postmeal

• Plasma triglyceride levels following meal ingestion (area under the plasma concentration versus time curve-AUC)

  0, 30, 60, 90, 120, 180, 240, 300 min postmeal

• Plasma NEFA levels following meal ingestion (area under the plasma concentration versus time curve-AUC)

  0, 30, 60, 90, 120, 180, 240, 300 min postmeal

• Plasma glycerol levels following meal ingestion (area under the plasma concentration versus time curve-AUC)

  0, 30, 60, 90, 120, 180, 240, 300 min postmeal

Study Arms (2)

Vinegar

ACTIVE COMPARATOR

0,50mmol vinegar (6% acetic acid)

Dietary Supplement: Vinegar

Placebo

PLACEBO COMPARATOR

50 ml water

Other: Placebo

Interventions

Vinegar DIETARY_SUPPLEMENT

0,50mmol vinegar (6% acetic acid)

Vinegar

Placebo OTHER

50 ml water

Placebo

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subjects with impaired glucose tolerance or newly diagnosed type 2 diabetes before the initiation of medication therapy
• Recreationally active
• With stable body weight and diet during the last two months.

You may not qualify if:

• Any systemic disease (besides glucose abnormalities)
• Any medication therapy
• Diabetic complications

Sponsors & Collaborators

• Attikon Hospital: lead
• Hellenic National Diabetes Center: collaborator

Related Publications (1)

• Mitrou P, Petsiou E, Papakonstantinou E, Maratou E, Lambadiari V, Dimitriadis P, Spanoudi F, Raptis SA, Dimitriadis G. Vinegar Consumption Increases Insulin-Stimulated Glucose Uptake by the Forearm Muscle in Humans with Type 2 Diabetes. J Diabetes Res. 2015;2015:175204. doi: 10.1155/2015/175204. Epub 2015 May 6.

  PMID: 26064976 DERIVED

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

Acetic Acid

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Intervention Hierarchy (Ancestors)

Acetates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Fatty Acids, Volatile; Fatty Acids; Lipids

Study Officials

• George D Dimitriadis, Professor

  Attikon Hospital

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Researcher, MD, PhD

Study Record Dates

• First Submitted: December 1, 2014
• First Posted: December 5, 2014
• Study Start: July 1, 2008
• Primary Completion: December 1, 2013
• Study Completion: December 1, 2014
• Last Updated: December 5, 2014

Record last verified: 2014-12