Studying Genes Using Cord Blood and Placenta Samples From Relatively Healthy Newborns and Samples From Younger Patients With Wilms Tumor

NCT01576211 | Completed

• 4 other identifiers: AREN12B6COG-AREN12B6CDR0000730596NCI-2012-00726
• Study Type: observational
• Target: 40
• Locations: 0 countries
• Sites: N/A

Brief Summary

RATIONALE: Studying samples of blood and tissue from newborns and from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies cord blood and placenta tissue from newborns, and tumor tissue samples from patients with Wilms tumor.

Conditions

Kidney Cancer

Keywords

Wilms tumor and other childhood kidney tumors

Outcome Measures

Primary Outcomes (2)

• Frequency of loss of imprinting at birth

• Association between methylation levels and gene expression

Interventions

DNA methylation analysis GENETIC

RNA analysis GENETIC

allele-specific oligonucleotide real-time quantitative polymerase chain reaction GENETIC

gene expression analysis GENETIC

nucleic acid sequencing GENETIC

polymorphism analysis GENETIC

laboratory biomarker analysis OTHER

Eligibility Criteria

• Age: Up to 21 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients registered on Children's Oncology Group Wilms tumor protocols

DISEASE CHARACTERISTICS: * Wilms tumor tissue samples from Caucasians (fresh or frozen), or DNA and ribonucleic acid (RNA) samples already isolated from patients registered on Children's Oncology Group Wilms tumor protocols * Normal/control blood samples from matched individuals * Cord blood/ placenta samples from the Michels lab Epigenetic Birth Cohort PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Children's Oncology Group: lead
• National Cancer Institute (NCI): collaborator

Biospecimen

Retention: SAMPLES WITH DNA

blood and tissue

MeSH Terms

Conditions

Kidney Neoplasms; Wilms Tumor

Interventions

DNA Methylation; Gene Expression Profiling; Base Sequence; Amplified Fragment Length Polymorphism Analysis

Condition Hierarchy (Ancestors)

Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases; Neoplasms, Complex and Mixed; Neoplasms by Histologic Type; Neoplastic Syndromes, Hereditary; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Methylation; Alkylation; Biochemical Phenomena; Chemical Phenomena; Metabolism; Genetic Phenomena; Genetic Techniques; Investigative Techniques; Molecular Structure; Genetic Structures; DNA Fingerprinting; Polymerase Chain Reaction; Nucleic Acid Amplification Techniques

Study Officials

• Karin Michels, MD, PhD

  Dana-Farber/Brigham and Women's Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 11, 2012
• First Posted: April 12, 2012
• Study Start: April 1, 2012
• Primary Completion: May 1, 2016
• Last Updated: May 18, 2016

Record last verified: 2016-05