Studying Biomarkers in Samples From Younger Patients With Wilms Tumor

NCT01542333 | Completed

• 4 other identifiers: AREN12B2COG-AREN12B2CDR0000726713NCI-2012-00686
• Study Type: observational
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

RATIONALE: Studying samples of tissue and urine from patients with cancer in the laboratory may help doctor learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies biomarkers in samples from younger patients with Wilms tumor.

Conditions

Kidney Cancer

Keywords

recurrent Wilms tumor and other childhood kidney tumors; stage I Wilms tumor; stage II Wilms tumor; stage III Wilms tumor; stage IV Wilms tumor; stage V Wilms tumor

Outcome Measures

Primary Outcomes (2)

• Molecular "finger print" of primary Wilms tumor in ethnically diverse children

• Protein "finger print" from the urine of ethnically diverse children

Interventions

gene expression analysis GENETIC

proteomic profiling GENETIC

reverse transcriptase-polymerase chain reaction GENETIC

western blotting GENETIC

immunohistochemistry staining method OTHER

laboratory biomarker analysis OTHER

spectroscopy PROCEDURE

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Diagnosed with Wilms tumor

DISEASE CHARACTERISTICS: * Diagnosed with Wilms tumor * Specimens from African-American and from Caucasian children * Specimens from each ethnicity who relapsed * Specimens from each ethnicity who did NOT relapse PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Children's Oncology Group: lead
• National Cancer Institute (NCI): collaborator

MeSH Terms

Conditions

Kidney Neoplasms; Wilms Tumor

Interventions

Gene Expression Profiling; Reverse Transcriptase Polymerase Chain Reaction; Blotting, Western; Immunohistochemistry; Spectrum Analysis

Condition Hierarchy (Ancestors)

Urologic Neoplasms; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases; Neoplasms, Complex and Mixed; Neoplasms by Histologic Type; Neoplastic Syndromes, Hereditary; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Genetic Techniques; Investigative Techniques; Polymerase Chain Reaction; Nucleic Acid Amplification Techniques; Electrophoresis; Chemistry Techniques, Analytical; Electrochemical Techniques; Immunoblotting; Immunoassay; Immunologic Techniques; Molecular Probe Techniques; Histocytochemistry; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Histological Techniques

Study Officials

• Harold N. Lovvorn, III, MD

  Vanderbilt Children's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 22, 2012
• First Posted: March 2, 2012
• Study Start: February 1, 2012
• Primary Completion: May 1, 2016
• Last Updated: May 18, 2016

Record last verified: 2016-05