Correlation Between Markers of Neuronal Injury and Cognitive Dysfunction After Coronary Artery Bypass Surgery
Study of Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction After Coronary Artery Bypass Graft Surgery
1 other identifier
observational
88
1 country
1
Brief Summary
This study aims to evaluate the possible Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction after Coronary Artery Bypass Surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Apr 2009
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 1, 2009
CompletedFirst Submitted
Initial submission to the registry
February 6, 2012
CompletedFirst Posted
Study publicly available on registry
March 9, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2013
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2013
CompletedMarch 9, 2012
March 1, 2012
3.8 years
February 6, 2012
March 6, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Score in Neuropsycological Tests
Tests for evaluation of quality of life, depressive synths and neuropsycho;logical battery to assess general mental status, learning, attention, visuospatial perception, immediate memory, operational and executive ask and recall, including processing speed. This assessment will be applied before surgery, and 3, 7,21 90 and 180 days after surgery.
1 year
Eligibility Criteria
Patients underwent for coronary artery bypass graft surgery.
You may qualify if:
- Patients underwent for coronary artery bypass graft surgery
You may not qualify if:
- History of brain disease or dementia, other psychiatric disorders that affect cognition
- Lack of proficiency in Portuguese language
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
General Hospital of the University od São Paulo Medical School
São Paulo, São Paulo, Brazil
Related Publications (1)
Silva FP, Schmidt AP, Valentin LS, Pinto KO, Zeferino SP, Oses JP, Wiener CD, Otsuki DA, Tort AB, Portela LV, Souza DO, Auler JO Jr, Carmona MJ. S100B protein and neuron-specific enolase as predictors of cognitive dysfunction after coronary artery bypass graft surgery: A prospective observational study. Eur J Anaesthesiol. 2016 Sep;33(9):681-9. doi: 10.1097/EJA.0000000000000450.
PMID: 27433840DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Maria JC Carmona, MD
University of Sao Paulo Medical School
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Study of Correlation Between Serum Levels of Markers of Neuronal Injury and Cognitive Dysfunction after Coronary Artery Bypass Surgery
Study Record Dates
First Submitted
February 6, 2012
First Posted
March 9, 2012
Study Start
April 1, 2009
Primary Completion
February 1, 2013
Study Completion
April 1, 2013
Last Updated
March 9, 2012
Record last verified: 2012-03