Identification of Factors Causing Postoperative Cognitive Dysfunction in Patients Undergoing Cardiac Surgery With CPB

NCT03641833 | Unknown

• 1 other identifier: POCD-1
• Study Type: observational
• Target: 130
• Locations: 1 country
• Sites: 1

Brief Summary

The incidence of cognitive decline occurs in 53% of patients after cardiac surgery. Causes of POCD can be various: age, duration of cardiac bypass, medicaments and many others. The aim of this study is to determine factors causing postoperative cognitive dysfunction (POCD) and to identify which of them are most important

Conditions

Postoperative Cognitive Dysfunction

Keywords

cardiac; surgery; postoperative cognitive dysfunction; bypass; brain biomarkers; transcranial Doppler

Outcome Measures

Primary Outcomes (1)

• Brain blood flow speed changes during surgery and correlation with POCD

  Transcranial Doppler will be performed to evaluate a.cerebri media blood flow speed during surgery using the 2MHz TCD ultrasound transducer over the temporal area. By adjusting the probe the curve of arteria will appear. Target measurement- mean flow velocity (MFV is measured in cm/s).

  3 years

Secondary Outcomes (2)

• Brain biomarker GFAP concentration chances before and after surgery and correlation with POCD.

  3 years

• Brain biomarker neurofilaments concentration chances before and after surgery and correlation with POCD.

  3 years

Other Outcomes (1)

• Determine factors causing POCD

  3 years

Interventions

blood sample for brain biomarkers DIAGNOSTIC_TEST

Transcranial Doppler will be performed to evaluate a.cerebri media blood flow speed during surgery.

Also known as: device

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Study include patients undergoing cardiac at Clinic of Cardiac, Vascular and Thoracic Surgery, Lithuanian University of Health Sciences

You may qualify if:

• Coronary artery bypass grafting or/and heart valve surgery;
• Patients age\>18years
• Cardiac output \>35%

You may not qualify if:

• Patient disagreement;
• Diseases causing cognitive dysfunction;
• Multi organic deficiency;
• Agents affecting central nervous system

Sponsors & Collaborators

• Rasa Bukauskiene: lead

Study Sites (1)

Lithuanian University of Health Sciences

Kaunas, Outside US/Canada/Australia, 50221, Lithuania

RECRUITING

MeSH Terms

Conditions

Postoperative Cognitive Complications

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cognitive Dysfunction; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Central Study Contacts

Rasa Bukauskiene

CONTACT

867111033; rasa.bukauskiene@lsmuni.lt

Edmundas Sirvinskas, Professor

CONTACT

+37037326171; edmundas.sirvinskas@lsmuni.lt

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Physician anaesthesiologist

Study Record Dates

• First Submitted: July 15, 2018
• First Posted: August 22, 2018
• Study Start: August 2, 2018
• Primary Completion: September 1, 2020
• Study Completion: September 1, 2021
• Last Updated: August 22, 2018

Record last verified: 2018-08

Locations

LI (1)