Correlation Between Postoperative Cognitive Dysfunction and Telomere Length in Patients With Non-cardiac Surgery

NCT03703973 | Unknown

• 1 other identifier: POCDLTL
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

To study on the Postoperative Cognitive Dysfunction: Correlations With Leukocyte telomere length。

Conditions

Postoperative Cognitive Dysfunction

Keywords

Postoperative Cognitive Dysfunction; Leukocyte Telomere Length

Outcome Measures

Primary Outcomes (11)

• the neuropsychological test to measure cognitive function

  1 day before surgery(baseline)

• Mini-Mental score examination [MMSE] used for screening of dementia

  1 day before surgery(baseline)

• the leukocyte telomere length

  on the surgery day

• the neuropsychological test to measure cognitive function

  within the first 7 days (plus or minus 2 days) after surgery

• Mini-Mental score examination [MMSE] used for screening of dementia

  within the first 7 days (plus or minus 2 days) after surgery

• the neuropsychological test to measure cognitive function

  within the first 3 months (plus or minus 1 month) after surgery

• Mini-Mental score examination [MMSE] used for screening of dementia

  within the first 3 months (plus or minus 1 month) after surgery

• the neuropsychological test to measure cognitive function

  within the first 1 year (plus or minus 3 months) after surgery

• Mini-Mental score examination [MMSE] used for screening of dementia

  within the first 1 year (plus or minus 3 months) after surgery

• the neuropsychological test to measure cognitive function

  within the first 3 years (plus or minus 1 year) after surgery

• Mini-Mental score examination [MMSE] used for screening of dementia

  within the first 3 years (plus or minus 1 year) after surgery

Study Arms (2)

study group

1000 Male and female patients undergoing non-cardiac surgery at the Affiliated Hospital of Xuzhou Medical University \[Jiangsu China\]. We do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test 1 day before (baseline) and 1 week,3 months,1 year and 3 years after surgery without safety issue.We also measure their preoperative leukocyte telomere length.

Diagnostic Test: Neuropsychology test

control group

We enroll 50 healthy volunteers and do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test at 1 day (baseline), 1 week, 3 months, 1 year and 3 years without safety issue.

Diagnostic Test: Neuropsychology test

Interventions

Neuropsychology test DIAGNOSTIC_TEST

We do the neuropsychological tests, Mini-Mental score examination (MMSE) and olfaction test 1 day before (baseline) and 1 week,3 months,1 year and 3 years after surgery without safety issue.

control group; study group

Eligibility Criteria

• Age: 60 Years - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

We included 1000 Male and female patients undergoing non-cardiac surgery and 50 healthy volunteers at the affiliated hospital of Xuzhou Medical University.

You may qualify if:

• Non-cardiac surgery patients;
• Age is greater than or equal to 65 years old;
• Han Nationality, mother tongue is chinese;
• ④The MMSE score:Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points;
• ⑤The Geriatric Depression Scale (GDS) grade 1 or 2;
• ⑥The important function without serious heart, brain, liver, kidney, lung and other organs;
• The ASA class I or II;
• The people signed informed consent.

You may not qualify if:

• The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; ②Had severe head and face disease, trauma history or history of surgery;
• Had a history of influenza in 3 weeks; ④The serious body disease and tobacco, wine and other substance abuse history; ⑤The presence of malignant tumor with shorter survival disease.

Sponsors & Collaborators

• Xuzhou Medical University: lead

Study Sites (1)

Department of Anesthesia of the Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, China

RECRUITING

MeSH Terms

Conditions

Postoperative Cognitive Complications

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cognitive Dysfunction; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Junli Cao

CONTACT

+86 15162160809; caojl0310@yahoo.com.cn

Yuan Han

CONTACT

+86 13852470693; hanyuan_trial@163.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Doctor-in-charge of Anesthetist

Study Record Dates

• First Submitted: September 27, 2018
• First Posted: October 12, 2018
• Study Start: August 1, 2016
• Primary Completion: December 31, 2020
• Study Completion: December 31, 2020
• Last Updated: October 12, 2018

Record last verified: 2018-10

Locations

CN (1)