NCT01528956

Brief Summary

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10

participants targeted

Target at below P25 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2012

Completed
4 days until next milestone

First Submitted

Initial submission to the registry

February 5, 2012

Completed
3 days until next milestone

First Posted

Study publicly available on registry

February 8, 2012

Completed
4.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2016

Completed
Last Updated

May 18, 2016

Status Verified

May 1, 2016

Enrollment Period

4.2 years

First QC Date

February 5, 2012

Last Update Submit

May 17, 2016

Conditions

Adrenocortical Carcinoma

Keywords

adrenocortical carcinoma

Outcome Measures

Primary Outcomes (2)

  • Identification of genetic factors affecting adrenocortical tumors

  • Comprehensive catalog of altered genes in adrenocortical samples

Interventions

DNA methylation analysisGENETIC
RNA analysisGENETIC
gene expression analysisGENETIC
nucleic acid sequencingGENETIC
polymorphism analysisGENETIC

Eligibility Criteria

AgeUp to 21 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Patients enrolled on COG-ARAR0332

DISEASE CHARACTERISTICS: * Banked tumor and blood samples obtained from patients enrolled on COG-ARAR0332 in North America and Brazil PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

MeSH Terms

Conditions

Adrenocortical Carcinoma

Interventions

DNA MethylationGene Expression ProfilingBase SequenceAmplified Fragment Length Polymorphism Analysis

Condition Hierarchy (Ancestors)

AdenocarcinomaCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsAdrenal Cortex NeoplasmsAdrenal Gland NeoplasmsEndocrine Gland NeoplasmsNeoplasms by SiteAdrenal Cortex DiseasesAdrenal Gland DiseasesEndocrine System Diseases

Intervention Hierarchy (Ancestors)

MethylationAlkylationBiochemical PhenomenaChemical PhenomenaMetabolismGenetic PhenomenaGenetic TechniquesInvestigative TechniquesMolecular StructureGenetic StructuresDNA FingerprintingPolymerase Chain ReactionNucleic Acid Amplification Techniques

Study Officials

  • Gerard Zambetti, PhD

    St. Jude Children's Research Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
RETROSPECTIVE
Sponsor Type
NETWORK
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 5, 2012

First Posted

February 8, 2012

Study Start

February 1, 2012

Primary Completion

May 1, 2016

Last Updated

May 18, 2016

Record last verified: 2016-05