Carbohydrate Mouth-rinse

NCT01527266 | Unknown

• 1 other identifier: 11-3-068
• Study Type: interventional
• Target: 15
• Locations: 1 country
• Sites: 1

Brief Summary

Several studies have reported that carbohydrate (CHO) ingestion can improve performance during exercise of short duration (less than 60 min). However, there is no apparent metabolic explanation for this observation because endogenous CHO stores should not be a limiting factor during short duration exercise. Nonetheless, several groups have attempted to investigate CHO administration during short duration exercise with varying results. When CHO was administered intravenously, no performance effect was observed despite greater plasma glucose availability (5). Therefore, it was suggested that during exercise of short duration, exogenous CHO ingestion may exert its ergogenic effect by action through the central nervous system, possibly mediated by glucose receptors in the mouth. The latter has been investigated using a CHO-mouth rinse, whereby the CHO solution is spat out to remove any influence of the gut on exogenous CHO oxidation or performance. Using this rinse, studies have demonstrated results both for (5, 16), and against (1, 19) any improvement in short duration exercise performance when compared with a placebo. The discrepancy in the findings may be due to testing subjects in the fed (1) or fasted-state (5), when liver glycogen stores may be compromised. However, no study has tested subjects in both the fasted and fed-state using a CHO-mouth rinse. It remains to be determined whether CHO-mouth rinse is only effective at improving short duration exercise performance when subjects are in the fasted, compared with the fed-state. The investigators will test the hypothesis that CHO-mouth rinse improves performance in the fasted-state only compared with a placebo-rinse.

Conditions

Carbohydrate Mouth-rinse on Time Trial Performance

Keywords

carbohydrate; performance; cycling

Outcome Measures

Primary Outcomes (4)

• Time to complete a set amount of work (time-trial performance)

  Time to complete the set amount of work measured in minutes. To determine if one intervention allows the subject to complete the given amount of work in a faster time period than the placebo.

  laboratory visit 2

• Time to complete a set amount of work (time trial performance)

  Time to complete the set amount of work measured in minutes. To determine if one intervention allows the subject to complete the given amount of work in a faster time period than the placebo.

  laboratory visit 3

• Time to complete a set amount of work (time-trial performance)

  Time to complete the set amount of work measured in minutes. To determine if one intervention allows the subject to complete the given amount of work in a faster time period than the placebo.

  laboratory visit 4

• Time to complete a set amount of work (time-trial performance)

  Time to complete the set amount of work measured in minutes. To determine if one intervention allows the subject to complete the given amount of work in a faster time period than the placebo.

  laboratory visit 5

Study Arms (4)

carbohydrate mouth rinse fasted

EXPERIMENTAL

sucrose mouth rinse in the fasted state

Dietary Supplement: Carbohydrate drink

carbohydrate mouth rinse fed

EXPERIMENTAL

sucrose mouth rinse fed state

Dietary Supplement: Carbohydrate drink

Placebo mouth rinse fed

PLACEBO COMPARATOR

placebo (non-caloric sweetened drink) in the fed state

Dietary Supplement: Placebo mouth rinse

Placebo mouth rinse fasted

PLACEBO COMPARATOR

placebo (non-caloric sweetened drink) in the fasted condition

Dietary Supplement: Placebo mouth rinse

Interventions

Carbohydrate drink DIETARY_SUPPLEMENT

sucrose beverage

carbohydrate mouth rinse fasted; carbohydrate mouth rinse fed

Placebo mouth rinse DIETARY_SUPPLEMENT

placebo; non-caloric sweetened beverage for use as a mouth rinse

Placebo mouth rinse fasted; Placebo mouth rinse fed

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy
• Male
• years of age
• Endurance cycling trained (≥ 3 sessions of endurance exercise per week)
• VO2 max ≥ 50 ml/kg/min
• Training history of more than one year of ≥ 3 sessions of endurance cycling exercise per week
• BMI \< 25 kg/m2

You may not qualify if:

• Use of medication
• Smoking

Sponsors & Collaborators

• Maastricht University Medical Center: lead

Study Sites (1)

Maastricht University

Maastricht, Netherlands

RECRUITING

Study Officials

• Luc van Loon, Ph.D.

  Maastricht University

  STUDY DIRECTOR

Central Study Contacts

Naomi Cermak, Ph.D.

CONTACT

31433881393; naomi.cermak@maastrichtuniversity.nl

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 12, 2012
• First Posted: February 6, 2012
• Study Start: February 1, 2012
• Primary Completion: December 1, 2012
• Study Completion: January 1, 2013
• Last Updated: October 17, 2012

Record last verified: 2012-10

Locations

NL (1)