Carbohydrate Mouth Rinsing and Cognitive Response During Exercise

NCT07099807 | Completed

• 1 other identifier: Parks0524
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates whether rinsing the mouth with a carbohydrate solution can improve brain oxygenation and cognitive function during high-intensity exercise. Eleven trained cyclists participated in multiple exercise sessions under different mouth rinse conditions. Brain oxygenation, perceived exertion, and cognitive performance were measured. The goal is to understand if this simple technique can support both physical and mental performance during demanding exercise.

Conditions

Exercise Performance of Fit Athletes

Outcome Measures

Primary Outcomes (1)

• Changes in prefrontal cortex oxygenation (ΔO2Hb)

  Immediately post-intervention and post-time trial (within same day)

Study Arms (3)

Carbohydrate Mouth Rinse

EXPERIMENTAL

Behavioral: Carbohydrate Mouth Rinse

Placebo Mouth Rinse

PLACEBO COMPARATOR

Behavioral: Placebo Mouth Rinse

Music Listening

EXPERIMENTAL

Behavioral: Music Listening

Interventions

Carbohydrate Mouth Rinse BEHAVIORAL

A 6.4% maltodextrin solution (64 g/L) was prepared using Nutricost Maltodextrin Powder. Participants performed five mouth rinses per trial, each using 25 mL of the solution for 10 seconds before expectorating. Each rinse was followed by a 30-second rest. Participants were instructed not to swallow the solution. Rinsing procedure was standardized across all sessions.

Carbohydrate Mouth Rinse

Placebo Mouth Rinse BEHAVIORAL

A placebo solution containing 0.05 g/L of non-caloric sucralose in distilled water was used to match sweetness and viscosity of the CHO-MR. Participants performed five rinses of 25 mL for 10 seconds each, spitting out the solution after each rinse. 30-second rest intervals followed each rinse. Swallowing was not allowed. Rinse frequency, volume, and duration were standardized.

Placebo Mouth Rinse

Music Listening BEHAVIORAL

Participants listened to high-tempo music (120 bpm) for 15 minutes before exercise using standardized earbuds. Music was selected from a public YouTube playlist titled "120 BPM Best Dance Music for Running and Working Out." Volume was calibrated at 65 dB (50% of max device volume). Auditory conditions were standardized across all participants.

Music Listening

Eligibility Criteria

• Age: 20 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Aged between 20 and 30 years
• Engaged in regular cycling training (≥5 sessions per week, \~4 hours per day)
• No known cardiovascular, neurological, or metabolic diseases
• Provided written informed consent

You may not qualify if:

• Current use of medication affecting cardiovascular or cognitive function
• Recent musculoskeletal injuries that affect cycling ability
• Smoking or excessive alcohol consumption
• Refusal or inability to comply with study procedures

Sponsors & Collaborators

• CHA University: lead

Study Sites (1)

CHA University, Human Performance Lab

Seongnam-si, Gyeonggi-do, 13488, South Korea

Location

Study Officials

• Seung-Bo Park

  CHA University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: CHA Bundang Medical Center

Study Record Dates

• First Submitted: July 25, 2025
• First Posted: August 1, 2025
• Study Start: February 28, 2025
• Primary Completion: May 15, 2025
• Study Completion: May 17, 2025
• Last Updated: August 1, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)