NCT01481246

Brief Summary

The Neurocognitive Study for the Aging (NEUROAGE) was initially funded by the Cyprus Innovation Foundation and has received subsequent funding by the European Union Regional Development Fund. The project focuses on the understanding of the effects of age on neurocognitive abilities such as attention, memory, language, categorization, and executive functioning. In addition, specific arms of the project investigate the effects of a theory-driven hierarchical training program, the Categorization Program, to improve cognitive abilities in adults with Mild Cognitive Impairment (MCI) and of a group intervention program focusing on cognitive and psychosocial abilities. Over 1000 adults ages 40 and older have been recruited in the NEUROAGE project thus far. The grant was awarded to the University of Cyprus, with Professor Fofi Constantinidou as the PI.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
1,000

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2009

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 1, 2009

Completed
2.4 years until next milestone

First Submitted

Initial submission to the registry

November 25, 2011

Completed
4 days until next milestone

First Posted

Study publicly available on registry

November 29, 2011

Completed
14 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2025

Completed
Last Updated

August 22, 2023

Status Verified

August 1, 2023

Enrollment Period

16.4 years

First QC Date

November 25, 2011

Last Update Submit

August 21, 2023

Conditions

AgingMemory ImpairmentCognitive DeclineMild Cognitive Disorder

Keywords

neurorehabilitationcognitionagingMCIcognitive decline

Outcome Measures

Primary Outcomes (1)

  • Neuropsychological Tests

    a variety of cognitive tests as well as psychosocial measures are used in this project

    on going

Study Arms (1)

Normal Aging/Cognitive Decline

Health adults as well as adults with MCI and early stage AD are being recruited in the study

Behavioral: Categorization trainingBehavioral: Psychosocial and Psychoeducational Group training

Interventions

Categorization trainingBEHAVIORAL

Behavioral intervention consisting of cognitive training exercises to improve categorization performance

Normal Aging/Cognitive Decline
Psychosocial and Psychoeducational Group trainingBEHAVIORAL

Group treatment with a focus on psychosocial and psychoeducational intervention in healthy adults and in adults with cognitive decline. Ten week cycle, 2 hours per week group intervention study.

Normal Aging/Cognitive Decline

Eligibility Criteria

Age60 Years - 90 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Normal older adults and adults with cognitive decline are recruited in this study

You may qualify if:

  • healthy with no prior neurological history

You may not qualify if:

  • prior neurological history or significant psychiatric history

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Cyprus

Nicosia, 1678, Cyprus

RECRUITING

Related Publications (2)

  • Chadjikyprianou A, Constantinidou F. Effectiveness of a Novel Multidimensional Group Intervention to Enhance Subjective Cognitive and Psychosocial Functioning in Healthy Older Adults. J Aging Health. 2025 Oct 24:8982643251391224. doi: 10.1177/08982643251391224. Online ahead of print.

    PMID: 41135181DERIVED

  • Chadjikyprianou A, Constantinidou F. A new multidimensional group intervention for cognitive and psychosocial functioning for older adults: Background, content, and process evaluation. Front Med (Lausanne). 2023 Apr 20;10:1161060. doi: 10.3389/fmed.2023.1161060. eCollection 2023.

    PMID: 37153102DERIVED

Related Links

Biospecimen

Retention: SAMPLES WITH DNA

APOE phenotyping

MeSH Terms

Conditions

Memory DisordersCognitive DysfunctionNeurocognitive Disorders

Condition Hierarchy (Ancestors)

Neurobehavioral ManifestationsNeurologic ManifestationsNervous System DiseasesSigns and SymptomsPathological Conditions, Signs and SymptomsCognition DisordersMental Disorders

Study Officials

  • Fofi Constantinidou, Ph.D.

    University of Cyprus

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Fofi Constantinidou, Ph.D.

CONTACT

35722892078fofic@ucy.ac.cy

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

November 25, 2011

First Posted

November 29, 2011

Study Start

July 1, 2009

Primary Completion

December 1, 2025

Study Completion

December 1, 2025

Last Updated

August 22, 2023

Record last verified: 2023-08

Locations

CY(1)