Prevalence and Pathophysiology of Sarcopenia in the Elderly Patient With Hip Fracture

NCT01477086 | Completed

• 1 other identifier: Viamed-Sarco-HF
• Study Type: observational
• Target: 198
• Locations: 1 country
• Sites: 1

Brief Summary

Sarcopenia is the loss of muscle mass and function that accompanies aging. The term sarcopenia comes from the Greek "sarx" (flesh) and "penia" (loss). Sarcopenia is a topic of great interest to geriatricians, and from 2010 discussing the possibility of considering it as a geriatric syndrome. Diagnostic criteria are reduced muscle mass, reduced strength and impaired physical performance. The presence of muscle mass reduction set presarcopenia diagnosis, when combined with one of the other two are talking about sarcopenia and when are the three is defined as severe sarcopenia. The hypothesis of our study is that sarcopenia is highly prevalent in older people with hip fracture. The increase in inflammatory indices of older people, along with bed rest, represent factors that accelerate the development of sarcopenia. These factors together could be the base of the high percentage of patients who do not recover the degree of autonomy before the fracture.

Conditions

Sarcopenia; Hip Fracture; Frailty

Keywords

Sarcopenia; Hip fracture; Frailty

Outcome Measures

Primary Outcomes (1)

• Sarcopenia prevalence

  To study the prevalence of sarcopenia in patients with hip fracture, those are hospitalized for rehabilitation. For the diagnosis of sarcopenia will use the criteria of the EWGSOP (1). Will be used bioelectrical impedance (BIA).For the BIA, we use the cut-off proposed by Jansen (2).

  Within the first 72 hours of admission.

Secondary Outcomes (5)

• Relationship inflammatory indices and sarcopenia.

  A admission and at discharge, after 30 days.

• Prevalence of falls.

  During the six months prior to admission.

• Acute mortality.

  During admission

• Relationship sarcopenia and frailty.

  At admission and after 30 days.

• Relationship sarcopenia and Barthel index.

  At admission and after 30 days .

Study Arms (1)

Hip fracture

We included patients with traumatic hip fracture, with surgery and who are admitted for rehabilitation

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Will be included in the study, prospectively, patients with hip fracture admitted to the Geriatric Rehabilitation Unit, Spain.

You may qualify if:

• Age equal to or greater than 65 years;
• Diagnosis of traumatic fracture of hip;
• To sign informed consent (patient or legal guardian, if cognitive impairment).

You may not qualify if:

• \- Excluding patients will not sign the informed consent.

Sponsors & Collaborators

• Hospital Viamed Valvanera, Spain: lead
• University of Navarra: collaborator

Study Sites (1)

Hospital Viamed Valvanera

Logroño, La Rioja, 26005, Spain

Location

Related Publications (9)

• Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul;39(4):412-23. doi: 10.1093/ageing/afq034. Epub 2010 Apr 13.

  PMID: 20392703 BACKGROUND

• Janssen I. Influence of sarcopenia on the development of physical disability: the Cardiovascular Health Study. J Am Geriatr Soc. 2006 Jan;54(1):56-62. doi: 10.1111/j.1532-5415.2005.00540.x.

  PMID: 16420198 BACKGROUND

• Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. doi: 10.1093/gerona/56.3.m146.

  PMID: 11253156 BACKGROUND

• Perez Durillo FT, Ruiz Lopez MD, Bouzas PR, Martin-Lagos A. [Nutritional status in elderly patients with a hip fracture]. Nutr Hosp. 2010 Jul-Aug;25(4):676-81. Spanish.

  PMID: 20694307 BACKGROUND

• Herrera A, Martinez AA, Ferrandez L, Gil E, Moreno A. Epidemiology of osteoporotic hip fractures in Spain. Int Orthop. 2006 Feb;30(1):11-4. doi: 10.1007/s00264-005-0026-2. Epub 2005 Nov 18.

  PMID: 16328387 BACKGROUND

• Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, Sayer AA. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing. 2011 Jul;40(4):423-9. doi: 10.1093/ageing/afr051. Epub 2011 May 30.

  PMID: 21624928 BACKGROUND

• Abizanda P, Lopez-Jimenez M, Lopez-Torres J, Atienzar-Nunez P, Naranjo JM, McAuley E. Validation of the Spanish version of the Short-Form Late-Life Function and Disability Instrument. J Am Geriatr Soc. 2011 May;59(5):893-9. doi: 10.1111/j.1532-5415.2011.03392.x.

  PMID: 21568958 BACKGROUND

• Malafarina V, Uriz-Otano F, Iniesta R, Gil-Guerrero L. Sarcopenia in the elderly: diagnosis, physiopathology and treatment. Maturitas. 2012 Feb;71(2):109-14. doi: 10.1016/j.maturitas.2011.11.012. Epub 2011 Dec 6.

  PMID: 22153348 BACKGROUND

• Malafarina V, Uriz-Otano F, Iniesta R, Gil-Guerrero L. Effectiveness of nutritional supplementation on muscle mass in treatment of sarcopenia in old age: a systematic review. J Am Med Dir Assoc. 2013 Jan;14(1):10-7. doi: 10.1016/j.jamda.2012.08.001. Epub 2012 Sep 13.

  PMID: 22980996 BACKGROUND

MeSH Terms

Conditions

Sarcopenia; Hip Fractures; Frailty

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries; Pathologic Processes

Study Officials

• Vincenzo Malafarina, MD MSc

  Clinica Los Manzanos, Lardero, Spain

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 19, 2011
• First Posted: November 22, 2011
• Study Start: January 1, 2012
• Primary Completion: December 1, 2015
• Study Completion: December 1, 2015
• Last Updated: February 5, 2016

Record last verified: 2016-02

Locations

ES (1)