NCT01453972

Brief Summary

The main purpose of our study is to examine the physiological adaptations in oxygen transport chain for high-intensity exercise and moderate exercise in overweight and obese humans. The main goals are:

  1. 1.To investigate the most effective short-and long-interval training in terms of VO2max, pulmonary diffusion, cardiac output, endothelial function and mitochondrial function.
  2. 2.How these physiological adaptations affect the aerobic endurance and performance, and how this training can reduce the risk of cardiovascular diseases related to overweight and obesity.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Oct 2011

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2011

Completed
9 days until next milestone

First Submitted

Initial submission to the registry

October 10, 2011

Completed
8 days until next milestone

First Posted

Study publicly available on registry

October 18, 2011

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2012

Completed
10 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2012

Completed
Last Updated

August 2, 2016

Status Verified

August 1, 2016

Enrollment Period

4 months

First QC Date

October 10, 2011

Last Update Submit

August 1, 2016

Conditions

OverweightObesity

Keywords

ExerciseHigh-intensityInterval training

Outcome Measures

Primary Outcomes (1)

  • Maximal oxygen uptake

    Change in maximal oxygen uptake will be measured after six weeks of various exercise training and related to changes in blood volume, cardiac function, endothelial function and mitochondrial function.

    6 weeks

Study Arms (3)

Long distanse moderate training

EXPERIMENTAL

40 minutes moderate treadmill running

Behavioral: Long distanse moderate training

Long interval training

EXPERIMENTAL

4x4min interval treadmill running

Behavioral: Long interval training

Short interval training

EXPERIMENTAL

10x1min interval treadmill running

Behavioral: Short interval training

Interventions

Long distanse moderate trainingBEHAVIORAL

Moderate exercise

Long distanse moderate training
Long interval trainingBEHAVIORAL

High-intensity exercise, long duration

Long interval training
Short interval trainingBEHAVIORAL

High intensity exercise, short duration

Short interval training

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • BMI \> 25

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Medical Faculty, Norwegian University of Science and Technology

Trondheim, Sør-Trøndelag, 7491, Norway

Location

Related Publications (1)

  • Baekkerud FH, Solberg F, Leinan IM, Wisloff U, Karlsen T, Rognmo O. Comparison of Three Popular Exercise Modalities on V O2max in Overweight and Obese. Med Sci Sports Exerc. 2016 Mar;48(3):491-8. doi: 10.1249/MSS.0000000000000777.

    PMID: 26440134RESULT

MeSH Terms

Conditions

OverweightObesityMotor Activity

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and SymptomsBehavior

Study Officials

  • Øivind Rognmo, PhD

    Norwegian University of Science and Technology

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 10, 2011

First Posted

October 18, 2011

Study Start

October 1, 2011

Primary Completion

February 1, 2012

Study Completion

December 1, 2012

Last Updated

August 2, 2016

Record last verified: 2016-08

Locations

NO(1)