Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1

NCT01430637 | Completed

• 3 other identifiers: ARST11B5COG-ARST11B5NCI-2011-03455
• Study Type: observational
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study is studying genes in samples from younger patients with desmoplastic small round cell tumor registered on COG-D9902 or COG-ABTR01B1.

Conditions

Sarcoma

Keywords

childhood desmoplastic small round cell tumor; metastatic childhood soft tissue sarcoma; nonmetastatic childhood soft tissue sarcoma; recurrent childhood soft tissue sarcoma; recurrent adult soft tissue sarcoma; stage I adult soft tissue sarcoma; stage II adult soft tissue sarcoma; stage III adult soft tissue sarcoma; stage IV adult soft tissue sarcoma; adult desmoplastic small round cell tumor

Outcome Measures

Primary Outcomes (2)

• Identification of novel mutations, single nucleotide polymorphisms, and copy number changes associated with DSRCT

• Identification of genomic regions involved in pathogenesis of DSRCT

Interventions

DNA analysis GENETIC

RNA analysis GENETIC

gene expression analysis GENETIC

mutation analysis GENETIC

nucleic acid sequencing GENETIC

polymerase chain reaction GENETIC

laboratory biomarker analysis OTHER

pharmacogenomic studies OTHER

Eligibility Criteria

• Age: Up to 50 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients registered on COG-D9902 or COG-ABTR01B1.

DISEASE CHARACTERISTICS: * Tumor and blood samples from patients registered on COG-D9902 or COG-ABTR01B1 obtained from the Cooperative Human Tissue Network (CHTN) and the Children's Oncology Group (COG) tumor banks * Matched normal samples PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Children's Oncology Group: lead
• National Cancer Institute (NCI): collaborator

MeSH Terms

Conditions

Sarcoma; Desmoplastic Small Round Cell Tumor

Interventions

Gene Expression Profiling; Base Sequence; Polymerase Chain Reaction; Pharmacogenomic Testing

Condition Hierarchy (Ancestors)

Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Neoplasms

Intervention Hierarchy (Ancestors)

Genetic Techniques; Investigative Techniques; Molecular Structure; Biochemical Phenomena; Chemical Phenomena; Genetic Structures; Genetic Phenomena; Nucleic Acid Amplification Techniques; Genetic Testing; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Genetic Services; Health Services; Health Care Facilities Workforce and Services; Diagnostic Services; Preventive Health Services

Study Officials

• Pooja Hingorani, MD

  Phoenix Children's Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 7, 2011
• First Posted: September 8, 2011
• Study Start: September 1, 2011
• Primary Completion: May 1, 2016
• Last Updated: May 18, 2016

Record last verified: 2016-05