Aerobic Training and Arterial Stiffness in Chronic Kidney Disease (CKD) Patients

NCT01399489 | Completed

• 1 other identifier: 1R15HL096097-01
• Study Type: interventional
• Target: 51
• Locations: 1 country
• Sites: 1

Brief Summary

The current study is designed to examine the impact of 16 weeks of moderate intensity aerobic training on arterial stiffness and blood pressure in stage 3 chronic kidney disease (CKD) patients. The investigators hypothesize that short term aerobic training will improve the stiffness of arteries in CKD patients.

Conditions

Chronic Kidney Disease; Hypertension; Diabetes

Keywords

Aerobic exercise; Moderate intensity; Ambulatory blood pressure; Post exercise hypotension

Outcome Measures

Primary Outcomes (1)

• Change from Baseline in Arterial stiffness (pulse wave velocity)

  Arterial stiffness is measured via pulse wave velocity. In addition augmentation index is also being assessed. Blood pressure is being measured under resting conditions and via 24 hr ambulatory devices.

  Change from Baseline in PWV at 16 weeks

Secondary Outcomes (2)

• Change in Resting blood pressure from Baseline

  Baseline prior to acute exercise vs post acute exercise

• Change in Resting blood pressure after 16 weeks of training

  Change in resting blood pressure from baseline at 16 weeks of training

Study Arms (2)

Exercise training

EXPERIMENTAL

Individuals randomized to this arm get 48 sessions of personal training in a state of the art fitness facility

Behavioral: Exercise training

Control

NO INTERVENTION

Individuals in the control arm are expected to continue to live normally, following their doctor's advice but not engage in any formal exercise training.

Interventions

Exercise training BEHAVIORAL

Participants receive 16 weeks of moderate intensity aerobic training under the supervision of personal trainers. Each session lasts from 15 to 55 minutes depending upon patient tolerance

Also known as: Non-pharmacologic, Lifestyle

Exercise training

Eligibility Criteria

• Age: 35 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Stage 3 Chronic Kidney Disease (CKD)
• Primary diagnosis hypertension or diabetes

You may not qualify if:

• Smokers
• Individuals \< 35 or \> 70 years of age
• Any contraindicators to exercise training as defined by the ACSM guidelines (GETP8)

Sponsors & Collaborators

• Springfield College: lead
• National Heart, Lung, and Blood Institute (NHLBI): collaborator

Study Sites (1)

Athletic Training and Exercise Science Building

Springfield, Massachusetts, 01109, United States

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic; Hypertension; Diabetes Mellitus; Post-Exercise Hypotension

Interventions

Exercise

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Vascular Diseases; Cardiovascular Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Orthostatic Intolerance; Primary Dysautonomias; Autonomic Nervous System Diseases; Nervous System Diseases; Hypotension

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Samuel A Headley, Ph.D

  Sprtingfield College

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor , Exercise Science

Study Record Dates

• First Submitted: January 31, 2011
• First Posted: July 21, 2011
• Study Start: September 1, 2009
• Primary Completion: December 1, 2012
• Study Completion: December 1, 2012
• Last Updated: January 23, 2014

Record last verified: 2014-01

Locations

US (1)