Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial

NCT01076881 | Completed

• 1 other identifier: UCPelotas01
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

This is a randomized trial with participants recruited from one dialysis unit of a Brazilian university hospital. Hemodialysis patients were assigned to receive the resistance exercise combined with an aerobic training or the resistance training alone for a period of 10 weeks. The functional performance of patients was assessed before and after the intervention through the six-minute walk test (6MWT). The difference over time of the 6MWT was compared between the groups through multivariate linear regression. Thirteen patients were allocated for each group of intervention. The difference in distance walked before and after intervention in the combined training group was of +39.7 (61.4) meters, and this difference in the resistance training group was of -19.2 (53.9) meters, p=0.01. In multivariate analysis with adjustment for age, skin color, gender, hematocrit, time since starting dialysis, Kt/V and baseline values of 6MWT, the type of training remained significantly associated with the amount of increase in walked distance. Although the best protocol of exercise for patients on dialysis is not yet clear, in the investigators sample of hemodialysis patients the combination of aerobic and resistance training was more effective to improve functional performance.

Conditions

End Stage Renal Disease

Outcome Measures

Primary Outcomes (1)

• physical performance

  10 weeks

Secondary Outcomes (1)

• dialysis adequacy (KtV)

  4/8/10 weeks

Study Arms (2)

combined aerobic and resistance training

EXPERIMENTAL

Behavioral: exercise training

resistance training alone

ACTIVE COMPARATOR

Behavioral: exercise training

Interventions

exercise training BEHAVIORAL

combined aerobic and resistance training; resistance training alone

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• to be on hemodialysis therapy for longer than 3 months
• to be already included in the resistance training protocol during dialysis
• to receive erythropoietin for the treatment of anemia
• hemoglobin level greater than 9.0 g/dL
• to be able to maintain sitting and standing balance and ambulatory without assistance.

You may not qualify if:

• symptomatic ischemic heart disease
• recent myocardial infarction of less than 6 months
• uncontrolled hypertension
• pericardial or pleural friction rub
• aortic stenosis
• active musculoskeletal lower-extremity problem, or history of vertebral fracture caused by osteoporosis
• patients were also excluded if they participated in formal organized exercise programs outside the dialysis unit.

Sponsors & Collaborators

• Universidade Católica de Pelotas: lead

Study Sites (1)

Hospital Universitário São Francisco de Paula

Pelotas, Rio Grande do Sul, Brazil

Location

MeSH Terms

Conditions

Kidney Failure, Chronic

Interventions

Exercise

Condition Hierarchy (Ancestors)

Renal Insufficiency, Chronic; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: February 17, 2010
• First Posted: February 26, 2010
• Study Start: December 1, 2008
• Primary Completion: March 1, 2009
• Study Completion: March 1, 2009
• Last Updated: February 26, 2010

Record last verified: 2010-02

Locations

BR (1)