A Comparison of the TIMI, GRACE and HEART Scores
HEART
A Prospective Comparison of the TIMI, GRACE and HEART Scores for Predicting Cardiovascular Events in Chest Pain Patients in the Emergency Room
1 other identifier
observational
2,440
1 country
10
Brief Summary
Various elements of patient history are checked and entered in the admission Case Recor Form (CRF). Three risk scores are calculated out of these elements, combined with physical examination, laboratory values and ECG-findings. The primary aim is to assess the positive and negative predictive values for a cardiovascular event of the three risk scores for chest pain patients. Secondary aim is to assess the sensitivity and specificity of various elements in the patient history for an acute coronary syndrome.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2009
Typical duration for all trials
10 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
June 1, 2009
CompletedFirst Submitted
Initial submission to the registry
June 9, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2010
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2011
CompletedFirst Posted
Study publicly available on registry
July 20, 2011
CompletedFebruary 17, 2016
February 1, 2016
1.5 years
June 9, 2010
February 16, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Occurence of MACE (Major Adverse Cardiac Events)
The number of patients diagnosed with MACE (Acute Myocardial Infarction, Percutaneous Coronary Intervention, Coronary Artery Bypass Grafting, Significant stenosis with conservative therapy, Death)
6 weeks after presentation
Secondary Outcomes (2)
The number of patients undergoing Coronary ArterioGraphy (CAG)
Three months after presentation
The number of patients suffering Acute Coronary Syndrome (ACS)
3 months after presentation
Study Arms (1)
Study Group
All included patients presented with chest pain at the emergency room within the inclusion period.
Eligibility Criteria
All patients presentating with chest pain in one of the participating hospitals.
You may qualify if:
- any patient visiting the cardiology emergency room due to chest pain
You may not qualify if:
- chest pain clearly due to rhythm disturbances or acute heart failure
- concomitant non cardiac disease with expected fatal outcome within 1 year
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- R&D Cardiologielead
- Sanoficollaborator
- Novartiscollaborator
Study Sites (10)
Meander Medical Centre
Amersfoort, Netherlands
Gelre Hospital
Apeldoorn, Netherlands
Reinier de Graaf Gasthuis
Delft, Netherlands
University Medical Centre Groningen
Groningen, Netherlands
Medical Centrum Haaglanden
Leidschendam, Netherlands
St Antonius Hospital
Nieuwegein, Netherlands
Medical Centre Haaglanden
The Hague, Netherlands
St Antonius Hospital
Utrecht, Netherlands
University Medical Centre Utrecht
Utrecht, Netherlands
Hofpoort Hospital
Woerden, Netherlands
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Pieter Doevendans, MD,PhD,Prof
UMC Utrecht
- PRINCIPAL INVESTIGATOR
Barbra Backus, MD
St Antionius Hospital Nieuwegein
- STUDY DIRECTOR
Jacob Six, MD, PhD
Hofpoort Hospital Woerden
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD, PhD
Study Record Dates
First Submitted
June 9, 2010
First Posted
July 20, 2011
Study Start
June 1, 2009
Primary Completion
December 1, 2010
Study Completion
July 1, 2011
Last Updated
February 17, 2016
Record last verified: 2016-02