NCT01358942

Brief Summary

This prospective observational study will evaluate the evolution of lung cancer related symptoms and their correlation with the disease control rate (complete response, partial response and stable disease) in patients with non-small cell lung cancer initiating first-line treatment with standard platinum-based chemotherapy with or without Avastin (bevacizumab). Data will be collected from each patient at baseline and after 4-6 cycles of chemotherapy.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
156

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started May 2011

Geographic Reach
1 country

37 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2011

Completed
19 days until next milestone

First Submitted

Initial submission to the registry

May 20, 2011

Completed
4 days until next milestone

First Posted

Study publicly available on registry

May 24, 2011

Completed
1.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 1, 2012

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 1, 2012

Completed
Last Updated

November 2, 2016

Status Verified

November 1, 2016

Enrollment Period

1.5 years

First QC Date

May 20, 2011

Last Update Submit

November 1, 2016

Conditions

Outcome Measures

Primary Outcomes (2)

  • Change in lung cancer related symptoms (LCSS questionnaire)

    up to approximately 6 months (4-6 cycles of chemotherapy)

  • Correlation of lung cancer related symptoms and disease control rate (complete response, partial response, stable disease according to RECIST criteria)

    approximately 2 years

Secondary Outcomes (1)

  • Frequency/severity of lung cancer related symptoms (LCSS questionnaire)

    approximately 2 years

Study Arms (1)

Cohort

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Non-small cell lung cancer patients initiating treatment with platinum-based chemotherapy +/- bevacizumab

You may qualify if:

  • Adult patients, \>/= 18 years of age
  • Histologically or cytologically confirmed non-small cell lung cancer
  • Initiating first-line treatment with standard platinum-based chemotherapy, with or without bevacizumab

You may not qualify if:

  • Contraindications to the use of platinum-based chemotherapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (37)

Unknown Facility

Vitoria-Gasteiz, Alava, 01009, Spain

Location

Unknown Facility

Alcoy, Alicante, 03804, Spain

Location

Unknown Facility

Alicante, Alicante, 3010, Spain

Location

Unknown Facility

Elche, Alicante, 03203, Spain

Location

Unknown Facility

Elda, Alicante, 03600, Spain

Location

Unknown Facility

Maó, Balearic Islands, 07703, Spain

Location

Unknown Facility

Palma de Mallorca, Balearic Islands, 07012, Spain

Location

Unknown Facility

Palma de Mallorca, Balearic Islands, 07014, Spain

Location

Unknown Facility

Barcelona, Barcelona, 08006, Spain

Location

Unknown Facility

Barcelona, Barcelona, 08017, Spain

Location

Unknown Facility

Barcelona, Barcelona, 08906, Spain

Location

Unknown Facility

Jerez de la Frontera, Cadiz, 11407, Spain

Location

Unknown Facility

Castellon, Castellon, 12002, Spain

Location

Unknown Facility

Donostia / San Sebastian, Guipuzcoa, 20080, Spain

Location

Unknown Facility

Jaén, Jaen, 23007, Spain

Location

Unknown Facility

Logroño, La Rioja, 26006, Spain

Location

Unknown Facility

Alcalá de Henares, Madrid, 28805, Spain

Location

Unknown Facility

Madrid, Madrid, 28031, Spain

Location

Unknown Facility

Madrid, Madrid, 28033, Spain

Location

Unknown Facility

Madrid, Madrid, 28040, Spain

Location

Unknown Facility

Madrid, Madrid, 28041, Spain

Location

Unknown Facility

Madrid, Madrid, 28046, Spain

Location

Unknown Facility

Madrid, Madrid, 28050, Spain

Location

Unknown Facility

Málaga, Malaga, 29010, Spain

Location

Unknown Facility

Melilla, Malaga, 52005, Spain

Location

Unknown Facility

Navarra, Navarre, 31008, Spain

Location

Unknown Facility

Pamplona, Navarre, 31006, Spain

Location

Unknown Facility

Pamplona, Navarre, 31008, Spain

Location

Unknown Facility

Tudela, Navarre, 46010, Spain

Location

Unknown Facility

Pontevedra, Pontevedra, 36002, Spain

Location

Unknown Facility

Oviedo, Principality of Asturias, 33011, Spain

Location

Unknown Facility

Segovia, Segovia, 40002, Spain

Location

Unknown Facility

Sagunto, Valencia, 46520, Spain

Location

Unknown Facility

Valencia, Valencia, 46015, Spain

Location

Unknown Facility

Valencia, Valencia, 46017, Spain

Location

Unknown Facility

Xàtiva, Valencia, 46800, Spain

Location

Unknown Facility

Bilbao, Vizcaya, 48013, Spain

Location

Study Officials

  • Clinical Trials

    Hoffmann-La Roche

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 20, 2011

First Posted

May 24, 2011

Study Start

May 1, 2011

Primary Completion

November 1, 2012

Study Completion

November 1, 2012

Last Updated

November 2, 2016

Record last verified: 2016-11

Locations