Biomarkers in Samples From Young Patients With Neuroblastoma

NCT01358604 | Completed

• 3 other identifiers: ANBL11B2COG-ANBL11B2NCI-2011-02855
• Study Type: observational
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

RATIONALE: Studying samples of tissue and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research study studies biomarkers in samples from young patients with neuroblastoma.

Conditions

Neuroblastoma

Keywords

localized resectable neuroblastoma; recurrent neuroblastoma; regional neuroblastoma; stage 4S neuroblastoma; localized unresectable neuroblastoma

Outcome Measures

Primary Outcomes (1)

• ROR1 is expressed on the surface of neuroblastoma cells and constitutes a suitable target for mAb therapy

Interventions

polymerase chain reaction GENETIC

protein expression analysis GENETIC

western blotting GENETIC

flow cytometry OTHER

immunohistochemistry staining method OTHER

laboratory biomarker analysis OTHER

Eligibility Criteria

• Age: Up to 120 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients diagnosed with neuroblastoma.

DISEASE CHARACTERISTICS: * Diagnosed with neuroblastoma * With or without N-myc amplification * Primary tumor samples as frozen tissue in liquid nitrogen or -80 degrees C * Bone marrow samples from high-risk patients as peripheral blood mononuclear cells (PBMC) that have been cryopreserved with DMSO as viable cells to be used for flow cytometry or slides of bone marrow that can be used for immunohistochemistry PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Children's Oncology Group: lead
• National Cancer Institute (NCI): collaborator

MeSH Terms

Conditions

Neuroblastoma

Interventions

Polymerase Chain Reaction; Blotting, Western; Flow Cytometry; Immunohistochemistry

Condition Hierarchy (Ancestors)

Neuroectodermal Tumors, Primitive, Peripheral; Neuroectodermal Tumors, Primitive; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue

Intervention Hierarchy (Ancestors)

Nucleic Acid Amplification Techniques; Genetic Techniques; Investigative Techniques; Electrophoresis; Chemistry Techniques, Analytical; Electrochemical Techniques; Immunoblotting; Immunoassay; Immunologic Techniques; Molecular Probe Techniques; Cell Separation; Cytological Techniques; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Cytophotometry; Fluorometry; Luminescent Measurements; Photometry; Histocytochemistry; Histological Techniques

Study Officials

• David Hema, MD, MPH

  NCI - Experimental Transplantation and Immunology Branch

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 18, 2011
• First Posted: May 23, 2011
• Study Start: May 1, 2011
• Primary Completion: April 1, 2016
• Study Completion: April 1, 2016
• Last Updated: April 15, 2016

Record last verified: 2016-04