Effect of Protein From Animal and Vegetable Sources on Appetite

NCT01345487 | Completed

• 1 other identifier: B275
• Study Type: interventional
• Target: 48
• Locations: 1 country
• Sites: 1

Brief Summary

New Nordic diet guidelines advocate a reduction in consumption of protein from animal sources such as beef and pork, due to environmental concerns. Instead, intake of protein from vegetable sources such as legumes and pulses should be increased. However, little is known about the effect of protein from (Nordic grown) beans and peas on body weight and appetite regulation. The objective of this study is to examine if protein from vegetable sources (beans and peas) is comparable to protein from animal sources regarding acute meal-induced satiety.

Conditions

Focus of Study: Appetite

Keywords

appetite; protein; legumes; meat

Outcome Measures

Primary Outcomes (2)

• Composite appetite score area under the curve (180 min)

  Composite score calculated from 10 cm visual analogue scale ratings: (desire to eat + hunger + prospective food consumption + (100-fullnes) + (100-satiety))/5

  Assessed every 30 min for 180 min after each of the three test meals which are served 1 wk apart

• Ad libitum energy intake

  180 min after each test meal an ad libitum meal of spaghetti bolognese is served, and the total energy intake is recorded.

  Assessed 180 min after each of the 3 test meals, which are served 1 wk apart

Secondary Outcomes (1)

• Appetite ratings

  Assessed every 30 min for 180 min after each or the 3 test meals which are served 1 wk apart

Study Arms (3)

Low Vegetable Protein

OTHER

Meal with 10 E% protein from fava beans/split peas

Other: Vegetable Protein

High Vegetable protein

EXPERIMENTAL

Meal with 20 E% protein from fava beans/split peas

Other: Vegetable Protein

High Animal Protein

EXPERIMENTAL

Meal with 20 E% protein from pork/beef

Other: Animal protein

Interventions

Vegetable Protein OTHER

Vegetable protein in the form of fava beans/split peas

High Vegetable protein; Low Vegetable Protein

Animal protein OTHER

Protein in the form of minced pork/beef

High Animal Protein

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• healthy men
• body mass index (BMI) 18.5-30.0

You may not qualify if:

• smoking
• participation in other studies for 4 mo prior to entry
• weight gain/loss \> 3 kg for to mo prior to entry
• Strenuous physical activity for \> 10 h/wk
• Use of medication that can affect appetite
• food allergies or relevance for the test meals
• Psychiatric or metabolic disorders prohibiting participation

Sponsors & Collaborators

• Arne Astrup: lead

Study Sites (1)

Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen

Frederiksberg C, 1958, Denmark

Location

MeSH Terms

Interventions

Plant Proteins, Dietary

Intervention Hierarchy (Ancestors)

Dietary Proteins; Proteins; Amino Acids, Peptides, and Proteins; Plant Proteins; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Study Officials

• Arne Astrup, Professor

  University of Copenhagen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: M.D

Study Record Dates

• First Submitted: April 27, 2011
• First Posted: May 2, 2011
• Study Start: April 1, 2011
• Primary Completion: June 1, 2011
• Study Completion: July 1, 2011
• Last Updated: March 25, 2015

Record last verified: 2015-03

Locations

DK (1)