NCT01318941

Brief Summary

This study will describe the long-term safety and effectiveness, treatment patterns,and patient reported quality of life associated with ranibizumab treatment in routine clinical practice for all approved indication included in the local product label.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
30,490

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Mar 2011

Longer than P75 for all trials

Geographic Reach
40 countries

452 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 1, 2011

Completed
16 days until next milestone

First Submitted

Initial submission to the registry

March 17, 2011

Completed
4 days until next milestone

First Posted

Study publicly available on registry

March 21, 2011

Completed
5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2016

Completed
Last Updated

May 23, 2016

Status Verified

May 1, 2016

Enrollment Period

5.1 years

First QC Date

March 17, 2011

Last Update Submit

May 20, 2016

Conditions

Keywords

Ophthalmology, age-related macular degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, ranibizumabOphthalmologyAge-related macular degenerationDiabetic Macular EdemaRetinal Vein OcclusionLUMINOUSRanibizumab

Outcome Measures

Primary Outcomes (3)

  • Mean Visual Acuity (VA) and mean change in VA

    3,6, and 12 months from the baseline visit, and annually thereafter

  • Incidence rate, relationship and severity of treatment emergent ocular and non-ocular adverse events

    Defined time periods during study duration from FPFV until 30 days after LPLV

  • Mean visual acuity at quarterly intervals for the primary treated eye set

    Quarterly intervals from baseline visit during study duration (5 years)

Secondary Outcomes (5)

  • Incidence rate of Adverse Events (AEs) and Serious Adverse Events (SAEs)

    From the time the patient signed the informed consent until 30 days after study discontinuation

  • Number of ranibizumab injections administered per patient, per eye, and per person-year

    annually

  • "National Eye Institute Visual Functioning Questionnaire-25" change from baseline

    annually

  • Overall number of ranibizumab injections, number of visits, time interval between injections, duration of treatment, number of re-treatment, and reasons for treatment termination

    Over time during study duration (5 years)

  • Change from baseline in National Eye Institute Visual Function Questionnaire 25 composite and sub-scale scores

    Over time during study duration (5 years)

Study Arms (1)

Ranibizumab

Drug: RanibizumabOther: Ranibizumab

Interventions

Ranibizumab

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Outpatient ophthalmology Clinics

You may qualify if:

  • Adult patients, within age limits as defined by local regulations and local product label, who have previously been treated with, who are currently being treated with or initiating treatment with ranibizumab for any approved indication included in the local product label
  • Willing and able to provide informed written consent personally or by legal proxy

You may not qualify if:

  • Simultaneous participation in a study that includes administration of any investigational drug or procedure
  • Systemic or ocular treatment with any VEGF inhibitor other than ranibizumab in the 90 days prior to enrollment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (463)

Novartis Investigative Site

Buenos Aires, Argentina, Argentina

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Novartis Investigative Site

Concepción del Uruguay, Argentina, Argentina

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Novartis Investigative Site

Córdoba, Argentina, CP 5000, Argentina

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Novartis Investigative Site

Guaymallén, Mendoza, Argentina, Argentina

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Novartis Investigative Site

Rosario, Argentina, Argentina

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Novartis Investigative Site

San Martin, Buenos Aires, Argentina, Argentina

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Novartis Investigative Site

Santa Fe, Argentina, Argentina

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Novartis Investigative Site

Lanús, Buenos Aires, B1824ABE, Argentina

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Novartis Investigative Site

Mar del Plata, Buenos Aires, Argentina

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Novartis Investigative Site

Rosario, Santa Fe Province, Argentina

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Novartis Investigative Site

Buenos Aires, 1121, Argentina

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Novartis Investigative Site

Buenos Aires, Argentina, Argentina

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Novartis Investigative Site

Buenos Aires, CP1425, Argentina

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Novartis Investigative Site

Caballito, C1437AVJ, Argentina

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Novartis Investigative Site

Ciudad de Buenos Aires,, Argentina, Argentina

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Novartis Investigative Site

La Plata, Argentina

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Novartis Investigative Site

Santa Fe, Argentina, Argentina

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Novartis Investigative Site

Chatswood, New South Wales, 2067, Australia

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Novartis Investigative Site

Forster, New South Wales, 2428, Australia

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Novartis Investigative Site

Kogarah, New South Wales, 2217, Australia

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Liverpool, New South Wales, 2170, Australia

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North Ryde, New South Wales, 2109, Australia

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Parramatta, New South Wales, 2150, Australia

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Strathfield, New South Wales, 2135, Australia

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Sydney, New South Wales, 2000, Australia

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Sydney, New South Wales, Australia, Australia

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Novartis Investigative Site

Westmead, New South Wales, 2145, Australia

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Novartis Investigative Site

Brisbane, Queensland, 4000, Australia

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Novartis Investigative Site

South Brisbane, Queensland, 4101, Australia

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Novartis Investigative Site

Southport, Queensland, 4125, Australia

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Novartis Investigative Site

Adelaide, South Australia, 5000, Australia

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North Adelaide, South Australia, 5006, Australia

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Hobart, Tasmania, 7000, Australia

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South Launceston, Tasmania, 7249, Australia

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East Melbourne, Victoria, 3002, Australia

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Geelong, Victoria, 3220, Australia

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Glen Waverley, Victoria, VIC 3150, Australia

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Oakleigh, Victoria, 3166, Australia

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Linz, A-4020, Austria

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Vienna, A 1040, Austria

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Aalst, Belgium, 9300, Belgium

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Aarschot, Belgium, 3200, Belgium

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Bonheiden, 2820, Belgium

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Brussels, 1070, Belgium

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Dinant, 5500, Belgium

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Edegem, 2650, Belgium

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Ghent, 9000, Belgium

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Hasselt, 3500, Belgium

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Leuven, 3000, Belgium

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Mouscron, 7700, Belgium

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Namur, 5000, Belgium

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Nivelles, 1400, Belgium

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Novartis Investigative Site

Reet, 2840, Belgium

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Yvoir, 5530, Belgium

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Zottegem, 9620, Belgium

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Goiânia, Goiás, 74210-010, Brazil

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Belo Horizonte, Minas Gerais, 30150-270, Brazil

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Rio de Janeiro, Rio de Janeiro, Brazil

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Porto Alegre, Rio Grande do Sul, Brazil

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Campinas, São Paulo, 13092-132, Brazil

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São Paulo, São Paulo, 01501-000, Brazil

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Calgary, Alberta, T2H0C8, Canada

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Victoria, British Columbia, V8V 4X3, Canada

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Miramichi, New Brunswick, E1V 1N9, Canada

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Halifax, Nova Scotia, B3H 2A5, Canada

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Brampton, Ontario, L6Y 0P6, Canada

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Downsview, Ontario, M5N 2V6, Canada

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East Brockville, Ontario, K6V 0V6, Canada

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London, Ontario, N6A 4G5, Canada

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Ottawa, Ontario, K1H 8L6, Canada

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Ottawa, Ontario, K1Z 8R2, Canada

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Scarborough Village, Ontario, M1R 3A6, Canada

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Toronto, Ontario, M5T 2S8, Canada

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Vaughan, Ontario, L4K 0C5, Canada

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Boisbriand, Quebec, J7H 1S6, Canada

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Barrie, ON L4M 4S, Canada

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Drummondville, J2B 5L4, Canada

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Hamilton, L9C 5R3, Canada

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Ontario, M1E 4A7, Canada

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Calama, Chile

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Beijing, Beijing Municipality, 100083, China

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Beijing, Beijing Municipality, 100730, China

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Beijing, Beijing Municipality, China

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Guangzhou, Guangdong, 510060, China

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Guiyang, Guizhou, 550004, China

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Wuhan, Hubei, 430060, China

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Jinan, Shandong, 250001, China

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Tianjin, Tianjin Municipality, 300020, China

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Kunming, Yunnan, 650021, China

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Beijing, 100034, China

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Beijing, 100730, China

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Beijing, China

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Changchun, 130041, China

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Chongqing, 400038, China

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Fujian, 361001, China

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Shanghai, 200080, China

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Shanghai, 200092, China

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Shanghai, China

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Ürümqi, 830000, China

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Barranquilla, Atlántico, Colombia

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Armenia, Quindío Department, Colombia

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Bogotá, Colombia

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Cali, Colombia

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Yopal, Colombia

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San José, Costa Rica, Costa Rica

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Brno-Bohunice, Czech Republic, 625 00, Czechia

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Hradec Králové, 500 05, Czechia

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Olomouc, 775 20, Czechia

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Ostrava-Poruba, 708 52, Czechia

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Pilsen, 304 60, Czechia

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Prague, 100 34, Czechia

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Prague, 12808, Czechia

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Prague, 16902, Czechia

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Ustri Nad Labem, 401 13, Czechia

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Santo Domingo, Republica Dominicana, Dominican Republic

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Ciudadela Kennedy, Guayaquil, Ecuador

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Cairo, Cairo Governorate, Egypt

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Giza, Egypt

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Poitiers, France, 86000, France

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Bordeaux, 33 000, France

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Créteil, 94000, France

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Dijon, 21034, France

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Lyon, 69317, France

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Melun, 77000, France

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Montargis, 45200, France

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Montauban, 82000, France

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Nantes, 44093, France

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Nice, 06200, France

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Paris, 75006, France

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Paris, 75010, France

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Paris, 75015, France

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Paris, 75940, France

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Reims, 51100, France

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Toulouse, 31059, France

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Vannes, 56000, France

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Augsburg, 86156, Germany

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Berlin, 10367, Germany

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Berlin, 10707, Germany

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Bonn, D-53105, Germany

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Cologne, 50924, Germany

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Dannenberg, 29451, Germany

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Hamburg, 22587, Germany

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Ingolstadt, 85049, Germany

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Lüdenscheid, 58515, Germany

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Münster, 48145, Germany

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Münster, 48149, Germany

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Neu-Ulm, 89231, Germany

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Osnabrück, 49076, Germany

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Regensburg, 93 047, Germany

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Rothenburg, 91541, Germany

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Schriesheim, 69198, Germany

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Tönisvorst, 47918, Germany

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Tübingen, 72076, Germany

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Alexandroupoli, Greece, 68100, Greece

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Athens, Greece, 11525, Greece

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Athens, Greece, 176 73, Greece

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Athens, GR, 106 72, Greece

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Heraklion - Crete, GR, 711 10, Greece

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Larissa, GR, 411 10, Greece

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Patra - RIO, GR, 265 04, Greece

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Rethymno, GR, 741 00, Greece

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Thessaloniki, GR, 546 29, Greece

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Athens, 10436, Greece

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Lamia, Phthiotis, 35100, Greece

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Guatemala City, Departamento de Guatemala, 01010, Guatemala

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Kowloon, Hong Kong, Hong Kong

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Budapest, 1133, Hungary

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Budapest, H-1083, Hungary

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Debrecen, 4012, Hungary

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Pécs, 7624, Hungary

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Szeged, 6720, Hungary

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Pātia, Bhudaneswar, 751 024, India

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Chennai, Tamil Nadu, 600 006, India

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Coimbatore, Tamil Nadu, 641 014, India

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Hyderabad, Telangana, 500 034, India

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Ahmedabad, 380009, India

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New Delhi, 110 029, India

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Dublin, 18, Ireland

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Dublin, Ireland

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Waterford, Ireland

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Haifa, 3339419, Israel

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Petah Tikva, 49100, Israel

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Tel Aviv, 64239, Israel

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Acquaviva delle Fonti, BA, 70021, Italy

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Cagliari, CA, 09124, Italy

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Genova, GE, 16132, Italy

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Alessandria, Italy

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Belluno, 32100, Italy

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Brescia, 25123, Italy

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Pisa, 56124, Italy

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Reggio Calabria, 89100, Italy

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Roma, 00161, Italy

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Roma, 00168, Italy

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Nagakute, Aichi-ken, 480-1195, Japan

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Nagoya, Aichi-ken, 462-0825, Japan

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Nagoya, Aichi-ken, 467-8602, Japan

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Nagoya, Aichi-ken, Japan

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Toyoake, Aichi-ken, 470-1192, Japan

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Aomori, Aomori, 030-8553, Japan

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Sakura, Chiba, 285-8741, Japan

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Matsuyama, Ehime, 790-8524, Japan

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Yoshida-gun, Fukui, 910-1193, Japan

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Fukuoka, Fukuoka, 812-8582, Japan

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Fukuoka, Fukuoka, 814-0180, Japan

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Kitakyushu, Fukuoka, 807-8556, Japan

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Fukushima, Fukushima, 960-1295, Japan

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Maebashi, Gunma, 371-8511, Japan

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Hiroshima, Hiroshima, 734-8551, Japan

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Sapporo, Hokkaido, 060-8543, Japan

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Sapporo, Hokkido, Japan

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Amagasaki, Hyōgo, 660-8550, Japan

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Kobe, Hyōgo, 657-0068, Japan

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Nishinomiya, Hyōgo, 663-8501, Japan

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Inashiki-gun, Ibaraki, 300-0395, Japan

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Tsukuba, Ibaraki, 305-8576, Japan

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Kanazawa, Ishikawa-ken, 920-8641, Japan

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Kita-gun, Kagawa-ken, 761-0793, Japan

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Ashigarakami-gun, Kanagawa, Japan

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Yokohama, Kanagawa, 232-0024, Japan

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Yokosuka, Kanagawa, 238-8558, Japan

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Yokohama, Kangawa, Japan

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Kyoto, Kyoto, 606-8507, Japan

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Tsu, Mie-ken, 514-8507, Japan

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Sendai, Miyagi, 981-8563, Japan

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Miyakonojō, Miyazaki, Japan

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Miyazaki, Miyazaki, 889-1692, Japan

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Suwa, Nagano, 392-8510, Japan

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Nagasaki, Nagasaki, 852-8501, Japan

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Kashihara, Nara, 634-8522, Japan

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Hirakata, Osaka, 573-1191, Japan

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Osaka, Osaka, 545-8586, Japan

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Sayama, Osaka, 589-8511, Japan

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Saitama, Saitama, 330-8503, Japan

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Saitama, Saitama, 338-8553, Japan

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Hamamatsu, Shizuoka, 430-8558, Japan

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Izunokuni, Shizuoka, 410-2295, Japan

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Shizuoka, Shizuoka, 422-8527, Japan

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Shimotsuka-gun, Tochigi, 321-0293, Japan

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Tokushima, Tokushima, 770-8503, Japan

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Bunkyo-ku, Tokyo, 113-8431, Japan

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Chiyoda-ku, Tokyo, 101-8309, Japan

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Mitaka, Tokyo, 181-8611, Japan

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Nerima-ku, Tokyo, Japan

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Shinjuku-ku, Tokyo, 160-0023, Japan

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Shinjuku-ku, Tokyo, 162-8666, Japan

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Urayasu, Tokyo, 279-0021, Japan

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Imizu-shi, Toyama, 939-0243, Japan

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Toyama, Toyama, 930-0194, Japan

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Yamagata, Yamagata, 990-9585, Japan

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Chūō, Yamanashi, 409-3898, Japan

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Akita, Japan

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Chiyoda-ku, 101-0062, Japan

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Ehime, Japan

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Gifu, Japan

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Hamamatsu, 430-0903, Japan

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Hokkaido, 080-0805, Japan

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Hokkaido, Japan

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Hyōgo, Japan

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Ishikawa, Japan

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Kagoshima, 890-0046, Japan

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Kagoshima, Japan

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Kakogawa-shi, 675-8611, Japan

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Kanagawa, Japan

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Kawasaki-shi, 211-0053, Japan

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Kitami-shi, 090-8666, Japan

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Koriyama-shi, 963-8585, Japan

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Kouchi, 783-8505, Japan

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Kyoto, 604-0837, Japan

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Miyagi, 980-8574, Japan

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Nagano, Japan

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Nagasaki, 852-8511, Japan

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Nantan-shi, 629-0392, Japan

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Osaka, Japan

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Ōtsu, 520-2192, Japan

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Saitama-ken, 336-0963, Japan

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Sanjo-shi, 955-0852, Japan

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Shizuoka, 420-0841, Japan

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Shunan-shi, 745-0017, Japan

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Tochigi, Japan

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Tokyo, 153-8515, Japan

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Tokyo, Japan

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Toyohashi, 441-8106, Japan

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Wakayama, 640-8558, Japan

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Yamagata, Japan

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Batu Caves, Selangor, 68100, Malaysia

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Kuala Lumpur, 50603, Malaysia

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Kuala Lumpur, 56000, Malaysia

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Kuala Lumpur, 59200, Malaysia

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Col. Lomas de Chapultepec, CP, 11000, Mexico

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Mexico City, Mexico City, 06030, Mexico

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Mexico City, Mexico City, 06800, Mexico

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Monterray, Nuevo León, 64710, Mexico

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Monterrey, Nuevo León, 64020, Mexico

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Mérida, Yucatán, Mexico

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Almere Stad, 1315 RA, Netherlands

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Amsterdam, 1071NT, Netherlands

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Tilburg, 5022 GC, Netherlands

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Panama City, Provincia de Panamá, 0819-12316, Panama

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Panama City, Provincia de Panamá, Panama

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Lima, Lima Province, LIMA 13, Peru

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San Borja, Lima region, 41, Peru

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San Isidro, Lima region, 27, Peru

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Bydgoszcz, 85-681, Poland

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Chojnice, 89-600, Poland

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Novartis Investigative Site

Chorzów, 40-064, Poland

Location

Novartis Investigative Site

Gdansk, 80-147, Poland

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Novartis Investigative Site

Gda¿sk, 80-402, Poland

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Novartis Investigative Site

Kalisz, 62 800, Poland

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Novartis Investigative Site

Kielce, 25-514, Poland

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Novartis Investigative Site

Krakow, 31-826, Poland

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Novartis Investigative Site

Lodz, 93 357, Poland

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Novartis Investigative Site

Olsztyn, 10-424, Poland

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Novartis Investigative Site

Poznan, 61-693, Poland

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Novartis Investigative Site

Warsaw, 02-097, Poland

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Novartis Investigative Site

Warsaw, 04-141, Poland

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Novartis Investigative Site

Wałbrzych, 58-300, Poland

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Novartis Investigative Site

Wołomin, 05-200, Poland

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Novartis Investigative Site

Coimbra, Portugal, 3000-354, Portugal

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Novartis Investigative Site

Coimbra, Portugal, 3030-163, Portugal

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Novartis Investigative Site

Aveiro, 3814-501, Portugal

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Novartis Investigative Site

Leiria, 2410-104, Portugal

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Novartis Investigative Site

Lisbon, 1500, Portugal

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Novartis Investigative Site

Matosinhos Municipality, 4454-509, Portugal

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Novartis Investigative Site

Santa Maria da Feira, 4520-211, Portugal

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Novartis Investigative Site

Cheboksary, 428028, Russia

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Novartis Investigative Site

Chelyabinsk, 454000, Russia

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Novartis Investigative Site

Chita, 672038, Russia

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Novartis Investigative Site

Irkutsk, 664033, Russia

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Novartis Investigative Site

Kazan', 420012, Russia

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Novartis Investigative Site

Khabarovsk, 680033, Russia

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Novartis Investigative Site

Krasnodar, 350012, Russia

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Novartis Investigative Site

Moscow, 105229, Russia

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Novartis Investigative Site

Moscow, 10562, Russia

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Novartis Investigative Site

Moscow, 119021, Russia

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Novartis Investigative Site

Novosibirsk, 630096, Russia

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Novartis Investigative Site

Penza, 440026, Russia

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Novartis Investigative Site

Saint Petersburg, Russia, Russia

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Novartis Investigative Site

Samara, 443079, Russia

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Novartis Investigative Site

Saratov, 410028, Russia

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Novartis Investigative Site

Surgut, 121359, Russia

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Novartis Investigative Site

Tambov, 392000, Russia

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Novartis Investigative Site

Tyumen, 625048, Russia

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Novartis Investigative Site

Ufa, 450077, Russia

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Novartis Investigative Site

Yakutsk, 677000, Russia

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Novartis Investigative Site

Riyadh, 11426, Saudi Arabia

Location

Novartis Investigative Site

Riyadh, 11462, Saudi Arabia

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Novartis Investigative Site

Riyadh, 11662, Saudi Arabia

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Novartis Investigative Site

Singapore, Singapore, 119074, Singapore

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Novartis Investigative Site

Singapore, 168751, Singapore

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Novartis Investigative Site

Singapore, 248649, Singapore

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Novartis Investigative Site

Banksa Bystrica, Slovak Republic, 974 17, Slovakia

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Novartis Investigative Site

Trebišov, Slovak Republic, 075 01, Slovakia

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Novartis Investigative Site

Bratislava, Slovakia, 833 01, Slovakia

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Novartis Investigative Site

Nové Zámky, Slovakia, 940 34, Slovakia

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Novartis Investigative Site

Zvolen, Slovakia, 960 01, Slovakia

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Novartis Investigative Site

Žilina, Slovakia, 01207, Slovakia

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Novartis Investigative Site

Bratislava, 813 69, Slovakia

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Novartis Investigative Site

Bratislava, 851 07, Slovakia

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Novartis Investigative Site

Ljubljana, 1000, Slovakia

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Novartis Investigative Site

Poprad, 058 01, Slovakia

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Novartis Investigative Site

Ružomberok, 034 01, Slovakia

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Novartis Investigative Site

Trenčín, SK-91171, Slovakia

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Novartis Investigative Site

Novo Mesto, Slovenia, Slovenia

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Novartis Investigative Site

Celje, 3000, Slovenia

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Novartis Investigative Site

Ljubljana, 1000, Slovenia

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Novartis Investigative Site

Maribor, 2000, Slovenia

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Novartis Investigative Site

Seongnam-si, Gyeonggi-do, 13620, South Korea

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Novartis Investigative Site

Suwon, Gyeonggi-do, 443-721, South Korea

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Novartis Investigative Site

Seoul, Korea, 05505, South Korea

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Novartis Investigative Site

Seoul, Korea, 110 744, South Korea

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Novartis Investigative Site

Busan, 612-896, South Korea

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Novartis Investigative Site

Daegu, 705-703, South Korea

Location

Novartis Investigative Site

Pusan, 602-739, South Korea

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Novartis Investigative Site

Seoul, 120-752, South Korea

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Novartis Investigative Site

Seoul, 130-872, South Korea

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Novartis Investigative Site

Seoul, 137-701, South Korea

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Novartis Investigative Site

Seoul, 150-950, South Korea

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Novartis Investigative Site

Seoul, South Korea

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Novartis Investigative Site

Taegu, 700 - 721, South Korea

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Novartis Investigative Site

Málaga, Andalusia, 29010, Spain

Location

Novartis Investigative Site

León, Castille and León, 24071, Spain

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Novartis Investigative Site

Salamanca, Castille and León, 32007, Spain

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Novartis Investigative Site

Valladolid, Castille and León, 47011, Spain

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Novartis Investigative Site

Barcelona, Catalonia, 08025, Spain

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Novartis Investigative Site

Sant Cugat del Vallès, Catalonia, 08190, Spain

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Novartis Investigative Site

Tarragona, Catalonia, 43005, Spain

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Novartis Investigative Site

Lugo, Galicia, 27003, Spain

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Novartis Investigative Site

Logroño, Hospital La Rioja Provincia, 26001, Spain

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Novartis Investigative Site

Murcia, Murcia, 30003, Spain

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Novartis Investigative Site

Valencia, Valencia, 46015, Spain

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Novartis Investigative Site

Valencia, Valencia, 46026, Spain

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Novartis Investigative Site

Zaragoza, Zaragoza, 50009, Spain

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Novartis Investigative Site

Barcelona, 08025, Spain

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Novartis Investigative Site

Burgos, 09006, Spain

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Novartis Investigative Site

Granollers, 08402, Spain

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Novartis Investigative Site

Madrid, 28008, Spain

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Novartis Investigative Site

Madrid, 28010, Spain

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Novartis Investigative Site

Madrid, 28040, Spain

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Novartis Investigative Site

Madrid, 28041, Spain

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Novartis Investigative Site

Madrid, 28805, Spain

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Novartis Investigative Site

Zaragoza, 50009, Spain

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Novartis Investigative Site

Ankara, Turkey, 06500, Turkey (Türkiye)

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Novartis Investigative Site

Altindag / Ankara, 06590, Turkey (Türkiye)

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Novartis Investigative Site

Ankara, 06100, Turkey (Türkiye)

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Novartis Investigative Site

Mecidiyekoy/Istanbul, 34394, Turkey (Türkiye)

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Novartis Investigative Site

Dnipropetrovsk, 49027, Ukraine

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Novartis Investigative Site

Kyiv, 03065, Ukraine

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Novartis Investigative Site

Luhansk, 91055, Ukraine

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Novartis Investigative Site

Odesa, Ukraine

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Novartis Investigative Site

Truro, Cornwall, TR1 3LJ, United Kingdom

Location

Novartis Investigative Site

Durham, County Durham, DH1 5TW, United Kingdom

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Novartis Investigative Site

Torquay, Devon,, TQ2 7AA, United Kingdom

Location

Novartis Investigative Site

Bolton, England, BL4 0JR, United Kingdom

Location

Novartis Investigative Site

Solihull, England, B91 2JL, United Kingdom

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Novartis Investigative Site

Southampton, England, SO16 6YD, United Kingdom

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Novartis Investigative Site

Wakefield, England, WF1 3JS, United Kingdom

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Novartis Investigative Site

Belfast, Essex, BT12 6BA, United Kingdom

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Novartis Investigative Site

Romford, Essex, RM7 0AG, United Kingdom

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Novartis Investigative Site

Cheltenham, Gloucestershire, GL53 7AN, United Kingdom

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Novartis Investigative Site

Blackburn, Lancashire, BB2 3HH, United Kingdom

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Novartis Investigative Site

Hull, Lancashire, HU3 2JZ, United Kingdom

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Novartis Investigative Site

Leicester, Lancashire, LE1 5WW, United Kingdom

Location

Novartis Investigative Site

Coventry, London, CV2 2DX, United Kingdom

Location

Novartis Investigative Site

Derby, London, DE22 3NE, United Kingdom

Location

Novartis Investigative Site

Leytonstone, London, E11 1NR, United Kingdom

Location

Novartis Investigative Site

Oxford, Oxfordshire, OX3 9DU, United Kingdom

Location

Novartis Investigative Site

Sheffield, South Yorkshire, S10 2JF, United Kingdom

Location

Novartis Investigative Site

Stoke-on-Trent, Staffordshire, ST4 7LN, United Kingdom

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Novartis Investigative Site

Frimley, Surrey, GU16 7UJ, United Kingdom

Location

Novartis Investigative Site

Guildford, Surrey, GU2 7XX, United Kingdom

Location

Novartis Investigative Site

Worcester, UK, WR5 1DD, United Kingdom

Location

Novartis Investigative Site

London, United Kingdom, EC1V 2PD, United Kingdom

Location

Novartis Investigative Site

Bradford, West Yorkshire, BD9 6RJ, United Kingdom

Location

Novartis Investigative Site

Bedford, MK429DJ, United Kingdom

Location

Novartis Investigative Site

Birmingham, B18 7QU, United Kingdom

Location

Novartis Investigative Site

Bristol, BS1 2LX, United Kingdom

Location

Novartis Investigative Site

Cardiff, CF14 4XN, United Kingdom

Location

Novartis Investigative Site

Cheshire, CW1 4QJ, United Kingdom

Location

Novartis Investigative Site

Colchester, CO3 3NB, United Kingdom

Location

Novartis Investigative Site

Inverness, IV2 3UJ, United Kingdom

Location

Novartis Investigative Site

Kent, CT1 3NG, United Kingdom

Location

Novartis Investigative Site

Leeds, LS9 7TF, United Kingdom

Location

Novartis Investigative Site

Liverpool, L9 7AL, United Kingdom

Location

Novartis Investigative Site

London, NW1 5QH, United Kingdom

Location

Novartis Investigative Site

London, NW3 2QG, United Kingdom

Location

Novartis Investigative Site

London, SE5 9RS, United Kingdom

Location

Novartis Investigative Site

Maidstone, ME16 9QQ, United Kingdom

Location

Novartis Investigative Site

Manchester, M13 9WL, United Kingdom

Location

Novartis Investigative Site

Merseyside, CH49 5PE, United Kingdom

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Novartis Investigative Site

Merseyside, L7 8PX, United Kingdom

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Novartis Investigative Site

Middlesbrough, TS4 3BW, United Kingdom

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Novartis Investigative Site

Newport, P030 5TG, United Kingdom

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Novartis Investigative Site

Portsmouth, PO6 3LY, United Kingdom

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Novartis Investigative Site

Southend, SS0 0RY, United Kingdom

Location

Novartis Investigative Site

Sunderland, SR2 9HP, United Kingdom

Location

Novartis Investigative Site

Uxbridge, UB8 3NN, United Kingdom

Location

Novartis Investigative Site

Wolverhampton, WV10 0QP, United Kingdom

Location

Novartis Investigative Site

York, YO31 8HE, United Kingdom

Location

Novartis Investigative Site

Porlamar Local 02, Isla Margarita, Venezuela

Location

Novartis Investigative Site

Caracas, Venezuela

Location

Novartis Investigative Site

Caracas, Piso 6, Ofic. 607, Venezuela

Location

Novartis Investigative Site

Santa Paula, Venezuela

Location

Novartis Investigative Site

Torre Venezuela, Piso 1, Venezuela

Location

Related Publications (5)

  • Holz FG, Minnella AM, Tuli R, Yoganathan P, Parikh S, Hamilton R; LUMINOUS study group. Ranibizumab treatment patterns in prior ranibizumab-treated neovascular age-related macular degeneration patients: Real-world outcomes from the LUMINOUS study. PLoS One. 2020 Dec 30;15(12):e0244183. doi: 10.1371/journal.pone.0244183. eCollection 2020.

  • Leys AM, Ramboer E, Favreau M, Denhaerynck K, MacDonald K, Abraham I, Brie H. Long-Term Ranibizumab Treatment in Neovascular Age-Related Macular Degeneration: A Belgian Subanalysis from the Global Real-World LUMINOUSTM Study. Clin Ophthalmol. 2020 Jun 2;14:1473-1481. doi: 10.2147/OPTH.S242547. eCollection 2020.

  • Pearce I, Clemens A, Brent MH, Lu L, Gallego-Pinazo R, Minnella AM, Creuzot-Garcher C, Spital G, Sakamoto T, Dunger-Baldauf C, McAllister IL; all the LUMINOUS study investigators. Real-world outcomes with ranibizumab in branch retinal vein occlusion: The prospective, global, LUMINOUS study. PLoS One. 2020 Jun 18;15(6):e0234739. doi: 10.1371/journal.pone.0234739. eCollection 2020.

  • Mitchell P, Sheidow TG, Farah ME, Mahmood S, Minnella AM, Eter N, Eldem B, Al-Dhibi H, Macfadden W, Parikh S, Dunger-Baldauf C, Mahgoub MM, Schmidt-Erfurth U; LUMINOUS study investigators. Effectiveness and safety of ranibizumab 0.5 mg in treatment-naive patients with diabetic macular edema: Results from the real-world global LUMINOUS study. PLoS One. 2020 Jun 3;15(6):e0233595. doi: 10.1371/journal.pone.0233595. eCollection 2020.

  • Schmidt-Erfurth U, Chong V, Loewenstein A, Larsen M, Souied E, Schlingemann R, Eldem B, Mones J, Richard G, Bandello F; European Society of Retina Specialists. Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA). Br J Ophthalmol. 2014 Sep;98(9):1144-67. doi: 10.1136/bjophthalmol-2014-305702.

MeSH Terms

Conditions

Retinal Vein OcclusionMacular Degeneration

Interventions

Ranibizumab

Condition Hierarchy (Ancestors)

Retinal DiseasesEye DiseasesVenous ThrombosisThrombosisEmbolism and ThrombosisVascular DiseasesCardiovascular DiseasesRetinal Degeneration

Intervention Hierarchy (Ancestors)

Antibodies, Monoclonal, HumanizedAntibodies, MonoclonalAntibodiesImmunoglobulinsImmunoproteinsBlood ProteinsProteinsAmino Acids, Peptides, and ProteinsSerum GlobulinsGlobulins

Study Officials

  • Novartis Pharmaceuticals

    Novartis Pharmaceuticals

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 17, 2011

First Posted

March 21, 2011

Study Start

March 1, 2011

Primary Completion

April 1, 2016

Study Completion

April 1, 2016

Last Updated

May 23, 2016

Record last verified: 2016-05

Locations