Multi-site Communication Deficits in Schizophrenia

NCT01317121 | Completed

• 1 other identifier: NeuroSFB-PV3632
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Multi-site Communication Deficits Underlying Cognitive Dysfunction in the Prodromal Phase and First Episode of Schizophrenia

Conditions

Schizophrenia; Psychosis

Keywords

Patients with a first episode of schizophrenia; Subjects at risk for psychosis

Outcome Measures

Primary Outcomes (1)

• Brain function

  baseline and one-year follow-up

Study Arms (3)

Subjects at risk for psychosis

Identification and clinical characterization of subjects with prodromal symptoms will be done in the early diagnosis outpatient center of the University Department of Psychiatry in Hamburg, Germany. Subjects At Risk Mental State (ARMS) for psychosis will be identified if they meet the criteria of the Structured Interview for Prodromal Syndromes (SIPS) (McGlashan et al 2001).

Patients with a first episode of schizophrenia

Patients with a first episode of schizophrenia will be recruited from inpatients at the Clinic for Psychiatry and Psychotherapy at the University Hospital (UKE) in Hamburg, Germany. All patients have to meet criteria for DSM-IV and ICD-10 diagnosis for schizophrenia.

Healthy control subjects

Healthy control subjects will be recruited from the hospital staff and students at the University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany. They have to be free from any neurological or psychiatric disorder, according to DSM-IV and ICD-10 criteria.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Three groups of subjects will be included: patients with a first episode of schizophrenia, subjects at increased risk for schizophrenia, and healthy control subjects.

You may qualify if:

• Signed written informed consent.
• Inpatients of the Clinic for Psychiatry and Psychotherapy of the University Hospital Hamburg-Eppendorf (UKE), Hamburg, Germany.
• Diagnosis of schizophrenia according to ICD-10 and DSM-IV criteria.

You may not qualify if:

• Epilepsy or other disorders of the nervous system, further psychiatric or neurological disorders.
• Suicidal tendencies.
• Acute or lifetime alcohol abuse.
• Hearing impairment.
• Intelligence quotient (IQ) below average.
• Non-magnetoencephalography(MEG)/ magnetic resonance imaging(MRI) compatible metallic implants.
• Signed written informed consent.
• Outpatients of the early diagnosis center of the University Department of Psychiatry at the University Hospital Hamburg-Eppendorf (UKE)Germany.
• Meeting high risk criteria for schizophrenia according to the Structured Interview for Prodromal Syndromes (SIPS).
• Epilepsy or other disorders of the nervous system, further psychiatric or neurological disorders.
• Suicidal tendencies.
• Acute or lifetime alcohol abuse.
• Hearing impairment.
• IQ below average.
• Non-MEG/MRI compatible metallic implants.

Sponsors & Collaborators

• Universitätsklinikum Hamburg-Eppendorf: lead

Study Sites (1)

Department of Psychiatry and Psychotherapy, University Hospital Hamburg-Eppendorf (UKE)

Hamburg, 20246, Germany

Location

MeSH Terms

Conditions

Schizophrenia; Psychotic Disorders

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Christoph Mulert, Prof. Dr.

  University Medical Center Hamburg-Eppendorf, Department of Psychiatry

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PI

Study Record Dates

• First Submitted: March 15, 2011
• First Posted: March 17, 2011
• Study Start: July 1, 2011
• Primary Completion: July 1, 2017
• Study Completion: July 1, 2017
• Last Updated: February 10, 2021

Record last verified: 2021-02

Locations

DE (1)