The Music Study in Refractory Psychosis

NCT02431949 | Unknown

• 1 other identifier: H14-02891
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The perception of music requires coordinated neural activities in distributed multi-functional centers across both hemispheres. The association between musical abilities and other general cognitive functions have been studied in several populations with inconsistent results. Schizophrenia is a major mental disorder that is strongly associated with cognitive deficits. These often appear before the onset of psychotic symptoms and persist throughout effective treatment of positive and negative symptoms. Like other disorders of psychosis, schizophrenia features general deficits in auditory memory and sensory processing. Recently, Sawada et al. (2014) and Wen et al. (2014) studied music abilities in Japanese and Chinese schizophrenic populations. They both used a standardized assessment for amusia called Montreal Battery of Evaluation of Amusia (MBEA) and found marked impairments in perception of scale, contour, interval, rhythm, meter and memory. Both studies showed that deficits in music perception were associated with cognitive deficits and negative symptoms. In regards to positive symptoms, Wen et al., but not Sawada et al., found a significant association. The present clinical study will assess musical abilities using the MBEA in a Canadian population with and without refractory psychosis. It will explore associations between musical deficits, positive and negative psychiatric symptomology and cognition. The patient population will have a diagnosis of schizophrenia, schizoaffective disorder, affective disorder with psychosis or non substance-related psychosis who were referred to the British Columbia Psychosis Program (BCPP) due to inadequate or no response to at least two trials of antipsychotics. A focus on refractory psychosis may provide greater insights because these patients have relatively more pronounced psychiatric symptoms and cognitive deficits. It will also be valuable to administer the MBEA assessment on a Canadian population, because the test was originally intended for Western populations and its musical phrases were designed with Western tonalities.

Conditions

Schizophrenia; Psychosis

Keywords

Music; Amusia

Outcome Measures

Primary Outcomes (1)

• Musical Ability (The Montreal Battery of Evaluation of Amusia)

  Assessment of musical ability based on scores from The Montreal Battery of Evaluation of Amusia

  2 hours

Secondary Outcomes (2)

• Cognitive Ability (NIH toolbox-cognitive battery scores)

  1 hour

• Mental Health Symptom Severity (Rating scales from Sci-PANSS and MINI Neuropsychiatric Interview)

  2 hours

Study Arms (2)

Controls

Participants without a psychosis disorder diagnosis.

Patients

Participants with a psychosis disorder diagnosis- recruited from the BC Psychosis Program.

Other: Admission to BCPP

Interventions

Admission to BCPP OTHER

There is no intervention associated with this study.

Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The participant population will include all patients who have been admitted to the British Columbia Psychosis Progarm (BCPP) at the University of British Columbia (UBC) Hospital. Admission criteria to BCPP include the following: 1) Must be 18 years or older who are medically stable; 2) Diagnosis of schizophrenia, schizoaffective disorder, mood disorder with psychosis, or non-substance-related psychosis requiring diagnostic clarification; 3) History of no response or inadequate response of positive symptoms to at least 2 adequate trials of antipsychotics (one of which is a second generation agent) by health authority tertiary clinical teams; 4) Incomplete recovery of social, vocational, and occupational functioning likely to respond to active intervention. Control subjects will be age and gender matched with patient participants.

You may qualify if:

• Admission to BC Psychosis Program at UBC Hospital in Vancouver, B.C. with a diagnosis of a psychosis disorder (patients only)
• Fluency in English (patients and controls)
• Able to give consent

You may not qualify if:

• For controls and patients:
• Presence of hearing deficits
• For controls only, history of:
• Diagnosis of psychosis disorder
• Antipsychotic medications

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

BC psychosis ward at UBC Hospital

Vancouver, British Columbia, Canada

RECRUITING

MeSH Terms

Conditions

Schizophrenia; Psychotic Disorders

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Study Officials

• Alasdair Barr, PhD

  The University of British Columbia

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Sujin Im, BSc

CONTACT

778-899-5969; sujinim92@gmail.com

Delrae Fawcett, MSc

CONTACT

604-349-8982; delrae.fawcett@ubc.ca

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Target Duration: 2 Weeks
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 28, 2015
• First Posted: May 1, 2015
• Study Start: June 1, 2015
• Primary Completion: May 1, 2017
• Study Completion: May 1, 2017
• Last Updated: May 25, 2016

Record last verified: 2016-05

Locations

CA (1)