AMIS Plus - National Registry of Acute Myocardial Infarction in Switzerland

NCT01305785 | Unknown

• 1 other identifier: AMIS Plus
• Study Type: observational
• Target: 60,000
• Locations: 1 country
• Sites: 1

Brief Summary

The AMIS Plus national registry collects and analyzes data on patients with acute myocardial infarction in Switzerland in the pre-admission, hospital and follow-up phases. Emphasis is placed on the evaluation of risk factors, diagnostics, urgent therapy strategies and treatment of acute coronary syndrome. The AMIS Plus data gathered are important for assessing guidelines, improving compliance with guidelines in clinical practice, investigating patient groups not extensively studied in large randomized trials, quality assurance as well as the continuous improvement of therapeutic strategies based on a large database.

Conditions

Acute Coronary Syndrome

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Acute myocardial infarction definition: 1. Characteristic ischemic symptoms 2. ECG changes indicating new ischemia (ST-T changes or new left bundle branch block) or developing pathological Q-waves 3. A dynamic increase or decrease in biomarker or troponin (I or T) levels above the individual hospital cut-off for MI. The internationally accepted guidelines for troponin levels are set at least one value above the 99th percentile of the upper reference limit (URL). Cut-off levels for either total creatine kinase (CK) or creatine kinase MB fraction (CK-MB) at least twice the upper limit of normal.

Sponsors & Collaborators

• Luzerner Kantonsspital: lead
• University of Zurich: collaborator
• University Hospital, Geneva: collaborator
• Insel Gruppe AG, University Hospital Bern: collaborator
• University Hospital, Basel, Switzerland: collaborator
• Triemli Hospital: collaborator
• Kantonsspital Baden: collaborator
• Cantonal Hospital of St. Gallen: collaborator
• University Hospital Freiburg: collaborator
• Cantonal Hospital, Frauenfeld: collaborator
• Hospital Centre Biel/Bienne: collaborator
• Spital Lachen AG: collaborator
• Cardiocentro Ticino: collaborator

Study Sites (1)

University of Zurich

Zurich, Switzerland

RECRUITING

Related Publications (10)

• Radovanovic D, Erne P. AMIS Plus: Swiss registry of acute coronary syndrome. Heart. 2010 Jun;96(12):917-21. doi: 10.1136/hrt.2009.192302.

  PMID: 20538666 RESULT

• Roberto M, Hoepli A, Cattaneo M, Radovanovic D, Rickli H, Erne P, Pedrazzini GB, Moccetti M. Patients With AMI and Severely Reduced LVEF, a Well-Defined, Still Extremely Vulnerable Population (Insights from AMIS Plus Registry). Am J Cardiol. 2023 Aug 1;200:190-201. doi: 10.1016/j.amjcard.2023.05.027. Epub 2023 Jun 20.

  PMID: 37348272 DERIVED

• Roberto M, Radovanovic D, Butta C, Tersalvi G, Krull J, Erne P, Rickli H, Pedrazzini GB, Moccetti M. Dual antiplatelet therapy is under-prescribed in patients with surgically treated acute myocardial infarction. Interact Cardiovasc Thorac Surg. 2021 Oct 29;33(5):687-694. doi: 10.1093/icvts/ivab159.

  PMID: 34171919 DERIVED

• Bruggmann C, Iglesias JF, Gex-Fabry M, Fesselet R, Vogt P, Sadeghipour F, Voirol P. Long-Term Quality of Prescription for ST-Segment Elevation Myocardial Infarction (STEMI) Patients: A Real World 1-Year Follow-Up Study. Am J Cardiovasc Drugs. 2020 Feb;20(1):105-115. doi: 10.1007/s40256-019-00361-5.

  PMID: 31300969 DERIVED

• Radovanovic D, Seifert B, Roffi M, Urban P, Rickli H, Pedrazzini G, Erne P. Gender differences in the decrease of in-hospital mortality in patients with acute myocardial infarction during the last 20 years in Switzerland. Open Heart. 2017 Nov 14;4(2):e000689. doi: 10.1136/openhrt-2017-000689. eCollection 2017.

  PMID: 29177059 DERIVED

• Bertel N, Witassek F, Puhan M, Erne P, Rickli H, Naegeli B, Pedrazzini G, Stauffer JC, Radovanovic D. Management and outcome of patients with acute myocardial infarction presenting with pacemaker rhythm. Int J Cardiol. 2017 Mar 1;230:604-609. doi: 10.1016/j.ijcard.2016.12.047. Epub 2016 Dec 20.

  PMID: 28040280 DERIVED

• Schoenenberger AW, Radovanovic D, Windecker S, Iglesias JF, Pedrazzini G, Stuck AE, Erne P; AMIS Plus Investigators. Temporal trends in the treatment and outcomes of elderly patients with acute coronary syndrome. Eur Heart J. 2016 Apr 21;37(16):1304-11. doi: 10.1093/eurheartj/ehv698. Epub 2016 Jan 12.

  PMID: 26757786 DERIVED

• Erne P, Radovanovic D, Seifert B, Bertel O, Urban P; AMIS Plus Investigators. Outcome of patients admitted with acute coronary syndrome on palliative treatment: insights from the nationwide AMIS Plus Registry 1997-2014. BMJ Open. 2015 Mar 2;5(3):e006218. doi: 10.1136/bmjopen-2014-006218.

  PMID: 25732032 DERIVED

• Wildi K, Cuculi F, Twerenbold R, Marxer T, Rubini Gimenez M, Reichlin T, Haaf P, Monsch R, Marsch S, Hunziker P, Bingisser R, Osswald S, Erne P, Mueller C. Incidence and timing of serious arrhythmias after early revascularization in non ST-elevation myocardial infarction. Eur Heart J Acute Cardiovasc Care. 2015 Aug;4(4):359-64. doi: 10.1177/2048872614557230. Epub 2014 Oct 27.

  PMID: 25348273 DERIVED

• Radovanovic D, Seifert B, Urban P, Eberli FR, Rickli H, Bertel O, Puhan MA, Erne P; AMIS Plus Investigators. Validity of Charlson Comorbidity Index in patients hospitalised with acute coronary syndrome. Insights from the nationwide AMIS Plus registry 2002-2012. Heart. 2014 Feb;100(4):288-94. doi: 10.1136/heartjnl-2013-304588. Epub 2013 Nov 1.

  PMID: 24186563 DERIVED

Related Links

• AMIS Plus Registry

MeSH Terms

Conditions

Acute Coronary Syndrome

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Study Officials

• Paul Erne, MD

  AMIS Plus Data Center

  STUDY DIRECTOR

Central Study Contacts

Paul Erne, MD

CONTACT

++41 41 205 51 06; Paul.Erne@luks.ch

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: AMIS Plus Steering Committee President

Study Record Dates

• First Submitted: February 28, 2011
• First Posted: March 1, 2011
• Study Start: January 1, 1997
• Last Updated: April 17, 2013

Record last verified: 2013-04

Locations

CH (1)