Myocardial Infarction Registry
MIR
Cardiac Biochemical and Omics-based Biomarkers in Patients Presenting Symptoms of Acute Coronary Syndrome in the Emergency Department (ACS Registry)
1 other identifier
observational
2,500
1 country
1
Brief Summary
The single-center MIR-registry was created to assess real-world prevalence, demographic characteristics and management of patients with acute coronary syndrome presenting in the emergency department (ED) of University of Heidelberg.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2014
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2014
CompletedFirst Submitted
Initial submission to the registry
November 7, 2023
CompletedFirst Posted
Study publicly available on registry
November 13, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2030
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2030
November 14, 2023
November 1, 2023
15.4 years
November 7, 2023
November 13, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
all-cause mortality
all-cause mortality during follow-up
12 months
Secondary Outcomes (3)
myocardial infarction
12 months
stroke
12 months
Rehospitalization
12 months
Study Arms (1)
MIR (Myocardial Infarction Registry)
All patients presenting to the Emergency Department with suspected acute coronary syndrome
Interventions
Eligibility Criteria
A cohort consisting of consecutive patients with suspected acute coronary syndrome presenting to the emergency department of the Heidelberg University Hospital.
You may qualify if:
- Acute myocardial infarction
- Unstable angina pectoris
- Myocarditis
- Heart failure
- Cardiomyopathies
- Pulmonary embolism
- Renal insufficiency
- Supraventricular and ventricular tachycardias
- Hypertensive crisis
- Non-cardiac chest pain
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital of Heidelberg
Heidelberg, Baden-Wurttemberg, 69120, Germany
Related Publications (1)
Yildirim M, Salbach C, Mueller-Hennessen M, Frey N, Giannitsis E. Comparative Analysis of Single- and Dual-Marker Strategies for Rapid Non-ST-Segment-Elevation Myocardial Infarction Rule-Out Using Cardiac Myosin-Binding Protein C, Copeptin, and High-Sensitivity Cardiac Troponin T in the Emergency Department. J Am Heart Assoc. 2025 May 20;14(10):e039379. doi: 10.1161/JAHA.124.039379. Epub 2025 May 13.
PMID: 40357668DERIVED
Biospecimen
Routine blood samples at presentation, a second blood sample for study purposes will be collected after 1 hour of the first index visit. On the routine follow-up visit, we will collect 20 ml for storage in addition to the routine blood test. Blood samples will be obtained by standard venous blood sampling. Assessment of parameters include laboratory values with special focus on findings related to myocardial injury as indicated by high sensitivity cardiac troponin T (hs-cTnT) and hs-cTnI. Moreover, the laboratory panel comprises other cardiac biomarkers, electrolytes, renal (creatine, glomerular filtration rate) and liver function (GOT, GPT, LDH), C-reactive protein, D-dimer etc.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr. med. univ.
Study Record Dates
First Submitted
November 7, 2023
First Posted
November 13, 2023
Study Start
August 1, 2014
Primary Completion (Estimated)
January 1, 2030
Study Completion (Estimated)
December 31, 2030
Last Updated
November 14, 2023
Record last verified: 2023-11
Data Sharing
- IPD Sharing
- Will not share