Observational Study Evaluating the Hemodynamic Relationship Between Volume Removal and Pulse Pressure Variation During Renal Replacement Therapy
Sponsor study identifier
observational
7
1 country
1
Study Start
February 2011
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 2015
Actual (reported)Study Completion
December 2015
Actual (reported)Dialysis is used to control the fluid balance and metabolic state of patients with kidney disease. Control of the metabolic state, via electrolytes, can be monitored using labs that are routinely drawn from patients undergoing continuous hemodialysis. Control of fluid removal is much more difficult. This study aims to determine whether changes in the blood pressure associated with breathing correlate with or predict intolerance to fluid responsiveness with continuous dialysis. We hypothesize that a measurement of changes in blood pressure with breathing called arterial pulse pressure variation may be able to predict the ability to remove fluid during continuous renal replacement therapy.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2015
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
January 27, 2011
Actual (reported)January 31, 2011
Actual (reported)February 2011
Date type not reportedThis date has not been verified as actual or estimated.
December 2015
Actual (reported)December 2015
Actual (reported)Predictive value of pulse pressure variation for tolerance of fluid removal on CVVHD
Iterative 24 hr periods for the duration of CRRT
Increased doses of vasoactive agents on CRRT
Iterative 24 hr periods for the duration of CRRT
Inability to meet goal ultrafiltration rate
Iterative 24 hr periods for the duration of CRRT
Adult ICU patients requiring CVVHD who have an indwelling arterial line.
The University of Chicago Medical Center
Chicago, Illinois, 60637, United States
Michael O'Connor, MD
University of Chicago
Jay L Koyner, MD
University of Chicago
7 participants (actual enrollment reported by the registry).
First Submitted
January 27, 2011
First Posted
January 31, 2011
Study Start
February 2011
Date type not reportedThis date has not been verified as actual or estimated.
The Effect of Thiamine vs. Placebo on VO2 in Critical Illness
Ultrasound Assessment of Volume in Patients on Continuous Dialysis
Hypotensive events on CRRT
Iterative 24 hr periods for the duration of CRRT
Contact the study team to confirm eligibility.
Primary Completion
December 2015
Actual (reported)Study Completion
December 2015
Actual (reported)Last Updated
August 31, 2016
Record last verified: 2016-08
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: