The Effects of Vertical Position on Gas Exchange in Patients With Respiratory Failure

NCT01705119 | Active Not Recruiting DMC

• 1 other identifier: 12-1773
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate how changing from a supine to upright position affects gas exchange for patients with hypoxemic respiratory failure. The research question is: will oxygen saturation and/or partial pressure of oxygen in the blood change when a patient with hypoxemic respiratory failure moves from a supine to upright position?

Conditions

Respiratory Failure

Keywords

Mechanically Ventilated; Critical Care

Outcome Measures

Primary Outcomes (1)

• PaO2 to FiO2 ratio

  change from baseline to 1 hr

Secondary Outcomes (3)

• Oxygen Saturation

  change from baseline to 1 hr

• change in blood PCO2

  change from baseline to 1 hr

• Change in blood pH

  change from baseline to 1hr

Other Outcomes (2)

• Tidal Volume

  change from baseline to 1 hr

• Vital Signs

  change from baseline to 1hr

Study Arms (1)

Mechanically Ventilated

EXPERIMENTAL

Other: Standing

Interventions

Standing OTHER

Mechanically Ventilated

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients aged ≥18 years who are mechanically ventilated
• An oxygen saturation of 88-94% or an arterial line

You may not qualify if:

• Mean arterial pressure \<65
• Heart rate \< 40 or \> 130 beats/min
• Respiratory rate \< 5 or \> 40 breaths/min
• Pulse oximetry \< 88%
• Evidence of elevated intracranial pressure
• Active gastrointestinal blood loss
• Active myocardial ischemia
• Pregnancy
• Actively undergoing a procedure
• Patient agitation requiring increased sedative administration in the last 30 mins
• Insecure airway (device)
• The patient was not ambulatory prior to hospitalization
• The patient's body habitus and/or mental status make it unsafe to stand up
• The patient has been placed on strict bed rest by the treating physicians

Sponsors & Collaborators

• University of Chicago: lead

Study Sites (1)

University of Chicago Medical Center

Chicago, Illinois, 60637, United States

Location

MeSH Terms

Conditions

Respiratory Insufficiency

Interventions

Standing Position

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Posture; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• John P Kress, MD

  University of Chicago

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 8, 2012
• First Posted: October 12, 2012
• Study Start: October 1, 2012
• Primary Completion: June 10, 2021
• Study Completion (Estimated): December 1, 2026
• Last Updated: January 13, 2026

Record last verified: 2026-01

Locations

US (1)