The Effects of Diet on Mood, Cognition and Appetite

NCT01201616 | Completed

• 1 other identifier: RIS030426a
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

A previous study has found that the consumption of a high fat, low carbohydrate meal results in increased feelings of calmness, friendliness and an increase in subjective energy levels in comparison to a low fat, high carbohydrate meal. The purpose of this study is to investigate whether a high fat, low carbohydrate diet for a longer duration (of 2 weeks) can enhance or sustain these changes in comparison to a low fat, high carbohydrate meal.

Conditions

Mild Cognitive Impairment

Keywords

Cognitive function; mood; women; high fat diet; high carbohydrate diet

Outcome Measures

Primary Outcomes (1)

• Clear-headedness

  Subjective mood measurement, assessed using visual analogue scale, in response to a test meal

  after 2 week intervention period

Secondary Outcomes (1)

• Reaction time

  after 2 week intervention

Study Arms (2)

High fat, low carbohydrate diet

EXPERIMENTAL

Fats intake 55% , Protein 17% and carbohydrate 28% of total energy

Other: High Fat Low Carbohydrate Diet

Low fat, high carbohydrate diet

ACTIVE COMPARATOR

Fat intake 20%, Protein 17% and carbohydrate 63% of total energy intake

Other: Low fat High Carbohydrate Diet

Interventions

High Fat Low Carbohydrate Diet OTHER

55% total energy intake from fats, 17% from protein and 28% from carbohydrate

Also known as: HFLC Diet

High fat, low carbohydrate diet

Low fat High Carbohydrate Diet OTHER

20% total energy intake from dietary fats, 17% from protein and 63% from carbohydrate

Also known as: LFHC Diet

Low fat, high carbohydrate diet

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• female
• BMI 18.5-25kg/m2
• aged 18-45 years
• regular breakfast eaters
• regular menstrual cycle
• healthy

You may not qualify if:

• Significant gastrointestinal disease, gastrointestinal surgery, diabetes or any other significant major medical morbidity
• History of significant eating disorder (anorexia, bulimia)
• Habitual dietary protein intake \>20% of total energy intake
• pregnancy or breast feeding
• anaemia (Hb \<11.5g/dL)
• random blood glucose concentration \>8mmol/l
• no medication use other than contraception
• significant weight loss/gain (\>14lb in previous 3 months)

Sponsors & Collaborators

• University of Nottingham: lead
• Mars, Inc.: collaborator

Study Sites (1)

University of Nottingham

Nottingham, Notts, NG72UH, United Kingdom

Location

Related Publications (2)

• Benton D, Parker PY. Breakfast, blood glucose, and cognition. Am J Clin Nutr. 1998 Apr;67(4):772S-778S. doi: 10.1093/ajcn/67.4.772S.

  PMID: 9537627 BACKGROUND

• Pollitt E, Mathews R. Breakfast and cognition: an integrative summary. Am J Clin Nutr. 1998 Apr;67(4):804S-813S. doi: 10.1093/ajcn/67.4.804S.

  PMID: 9537633 BACKGROUND

MeSH Terms

Conditions

Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Ian A Macdonald, PhD

  University of Nottingham

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Senior Research Fellow

Study Record Dates

• First Submitted: September 13, 2010
• First Posted: September 14, 2010
• Study Start: July 1, 2010
• Primary Completion: December 1, 2012
• Study Completion: March 1, 2013
• Last Updated: March 27, 2018

Record last verified: 2018-03

Locations

GB (1)