NCT01186055|Completed
Brain Activity and Smoking Cessation
Neural Mechanisms Underlying Smoking Relapse (Center for Interdisciplinary Research on Nicotine Addiction - CIRNA)
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Neural Mechanisms Underlying Smoking Relapse (Center for Interdisciplinary Research on Nicotine Addiction - CIRNA)
Sponsor study identifier
Secondary identifiers
NIH
observational
80
1 country
1
Study Start
April 2010
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
February 2013
Actual (reported)Study Completion
February 2013
Actual (reported)In the current study, the investigators propose to test: (1) whether brain activation and connectivity in a resting state, assessed by ASL perfusion MRI, BOLD fMRI, and diffusion tensor imaging (DTI) predicts smoking relapse, and (2) whether brain activation, assessed by BOLD fMRI during performance of neurobehavioral probes for executive cognitive function, stress and cue reactivity, predicts smoking relapse.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 2013
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 2010
Date type not reportedThis date has not been verified as actual or estimated.
August 19, 2010
Actual (reported)August 20, 2010
Actual (reported)February 2013
Actual (reported)February 2013
Actual (reported)Association between brain activity following nicotine abstinence and quit rates after 8 weeks post-target quit date
The correlation between cerebral blood flow or BOLD signal changes and days to relapse will be examined using separate GLM analyses. For this analysis, each session's (abstinence, smoking) mean CBF (or BOLD signal) will be calculated for the ROIs. Mean values from each ROI will be used as predictors in a longitudinal logistic regression model of quitting success.
8 weeks
Behavioral performance and BOLD signal change during neurocognitive tasks
24 hours
Cravings for Cigarettes
24 hours
Individuals will receive individual and group counseling for 8 weeks (6 visits) while they quit smoking.
Participants shall all receive 8 weeks (6 weeks) of group or individual counseling during their quit attempt.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
100 treatment seeking smokers ages 18 to 65 who report smoking at least 10 cigarettes per day for at least the last 6-months.
3535 Market Street, Suite 4100, University of Pennsylvania
Philadelphia, Pennsylvania, 19104, United States
1. A 2ml saliva sample for DNA collection \& genotyping (Oragene™). 2. A 5ml saliva sample to assess nicotine metabolites (e.g. cotinine and 3-hydroxycotinine).
Caryn Lerman, PhD
University of Pennsylvania
80 participants (actual enrollment reported by the registry).
First Submitted
August 19, 2010
First Posted
August 20, 2010
Study Start
April 2010
Date type not reportedThis date has not been verified as actual or estimated.
Measuring Smoking Behaviors While Using Varenicline
Contact the study team to confirm eligibility.
Primary Completion
February 2013
Actual (reported)Study Completion
February 2013
Actual (reported)Last Updated
July 15, 2013
Record last verified: 2013-07
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Source: ClinicalTrials.gov.
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