Nicotine Dependence
374
30
36
271
Key Insights
Highlights
Success Rate
92% trial completion (above average)
Published Results
150 trials with published results (40%)
Research Maturity
271 completed trials (72% of total)
Clinical Risk Assessment
Based on trial outcomes
Low Risk
Score: 27/100
6.7%
25 terminated out of 374 trials
91.6%
+5.0% vs benchmark
17%
62 trials in Phase 3/4
55%
150 of 271 completed with results
Key Signals
Data Visualizations
Phase Distribution
Trial Status
Trial Success Rate
Benchmark: 86.5%
Based on 271 completed trials
Clinical Trials (374)
Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal
Puff Topography and Sensory Effects Across IQOS Device Generations
Effect of Teleconsultation Counseling on Smoking Cessation
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
Orexin s Role in the Neurobiology of Substance Use Disorder
A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users
Social Media Support Groups for Adolescent Vaping Cessation
Cognitive Task Development and Implementation for Functional MRI Studies
Sex Differences in E-Cigarette Perception
Electronic Cigarettes and Reactivity to Smoking Cues
Targeting Orexin to Treat Nicotine Dependence
Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)
Brain/Craving Response to Smoking Cues After Oral Nicotine Pouch Use
Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures
Feasibility of a Medical-Legal Partnership Model to Connect Coal Miners QuitAid
Abuse Liability and Appeal of Oral Nicotine Products
Smart Olfaction App to Reduce Relapse
Behavioral Intervention for Youth to Promote Vaping Cessation
Young Adult Tobacco/Nicotine and Cannabis Co-use
Multimodal Neuroimaging Genetic Biomarkers of Nicotine AddictionSeverity