The Effect of Nicardipine on Kidney Function During Orthognathic Surgery Under Hypotensive Anesthesia
1 other identifier
interventional
46
0 countries
N/A
Brief Summary
Since nicardipine is known to protect kidney function, nicardipine infusion will result in better renal parameters measured in this study.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Aug 2010
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2010
CompletedFirst Submitted
Initial submission to the registry
August 2, 2010
CompletedFirst Posted
Study publicly available on registry
August 5, 2010
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2011
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2011
CompletedJune 13, 2013
June 1, 2013
10 months
August 2, 2010
June 11, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Creatinine Clearance
Hypotensive anesthesia means that we maintain the mean blood pressure between 55 \& 65 mmHg during surgery to decrease the blood loss. The specific time point is exactly 2hr after we star to lower the blood pressure.
2hr after the start of hypotensive anesthesia
Study Arms (2)
nicardipine
EXPERIMENTALremifentanil
ACTIVE COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- healthy adult patients undergoing hypotensive anesthesia
You may not qualify if:
- patients with any co-morbidity
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Ji Young Kim
Severance hospital, YUHS
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 2, 2010
First Posted
August 5, 2010
Study Start
August 1, 2010
Primary Completion
June 1, 2011
Study Completion
December 1, 2011
Last Updated
June 13, 2013
Record last verified: 2013-06